DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alk and CERK1

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_566689.2	Gene:	CERK1 / 821717	AraportID:	AT3G21630	Length:	617	Species:	Arabidopsis thaliana

Alignment Length:	321	Identity:	89/321 - (27%)
Similarity:	151/321 - (47%)	Gaps:	51/321 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly  1099 KSSFQYLVSILMISLAVLFICIAAL--IFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDS 1161
            |||.|..|...:|:..|:.:.:|.|  :|::|..| ||.:||...   ....:.|:...::...:
plant   223 KSSKQDGVGAGVIAGIVIGVIVALLLILFIVYYAY-RKNKSKGDS---FSSSIPLSTKADHASST 283

  Fly  1162 NLNNFNPNYGCDGILNGHIDVN-------SLPQVAR--DSLQLVNALGKGAFGEVYMALYRHRDG 1217
            :|.  :...|..|:..|...::       ||.::|:  |:..|...:|:|.||.||.|..|   |
plant   284 SLQ--SGGLGGAGVSPGIAAISVDKSVEFSLEELAKATDNFNLSFKIGQGGFGAVYYAELR---G 343

  Fly  1218 DAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQ 1282
            :.    .|:|.:    ..|..:.||.|..::.:.:|.|:|.|||.|.:.. .::|.|.:..|:|.
plant   344 EK----AAIKKM----DMEASKQFLAELKVLTRVHHVNLVRLIGYCVEGS-LFLVYEYVENGNLG 399

  Fly  1283 KFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKR---FIHRDIAARNCLLSSKGPGRVVK 1344
            :.|..:...|     |.....:..|||.|:|..|:....   ::||||.:.|.|:..|..   .|
plant   400 QHLHGSGREP-----LPWTKRVQIALDSARGLEYIHEHTVPVYVHRDIKSANILIDQKFR---AK 456

  Fly  1345 IADFGMSRDIYRSDYYRKGGK----AMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFS 1401
            :||||:::      ....||.    ||....:|.||. :.|..::|.||::||::|:|:.|
plant   457 VADFGLTK------LTEVGGSATRGAMGTFGYMAPET-VYGEVSAKVDVYAFGVVLYELIS 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	66/225 (29%)
		TyrKc	1193..1460	CDD:197581	64/216 (30%)
CERK1	NP_566689.2	mltD	<104..202	CDD:182727
CERK1	NP_566689.2	PKc_like	328..587	CDD:419665	63/210 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910