DRSC/TRiP Functional Genomics Resources

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Protein Alignment Alk and csf1ra

DIOPT Version :10

Sequence 1:NP_652600.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:NP_571747.1 Gene:csf1ra / 64274 ZFINID:ZDB-GENE-001205-1 Length:977 Species:Danio rerio


Alignment Length:599 Identity:160/599 - (26%)
Similarity:240/599 - (40%) Gaps:214/599 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1061 YRCVALDEFRSKVRCICPDGWS-LKRDNHTACEIREEA--------------------------- 1097
            |:|..       :|..||:..: |:.......|.::|:                           
Zfish   443 YQCTG-------IRTTCPENTTDLQPIQTQTVEFQKESFGAVGVESVLTVGPNRRMTVVCVAFNL 500

  Fly  1098 ---GKSSFQYLVS------------ILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQ 1147
               |..:|...||            :.|:.|.:|      ||||:| :|::|.:.:.|.|:    
Zfish   501 VGQGSDTFSMEVSDQIFTSAMCGSTVAMVVLGLL------LIFMIY-KYKQKPRYEIRWKI---- 554

  Fly  1148 DLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLP-----QVARDSLQLVNALGKGAFGEV 1207
                      |:.:|.||:.           .||...||     :..||.|:|...||.||||:|
Zfish   555 ----------IEATNGNNYT-----------FIDPTQLPYNEKWEFPRDKLKLGKTLGAGAFGKV 598

  Fly  1208 YMALYRHRDGDAVEMG-------VAVKTLREDPKREKEEDFLKEAAIMAKF-NHPNMVHLIGVCF 1264
            .       :..|..:|       ||||.|:.....::.|..:.|..|::.. .|.|:|:|:|.|.
Zfish   599 V-------EATAYGLGKEDNITRVAVKMLKASAHPDEREALMSELKILSHLGQHKNIVNLLGACT 656

  Fly  1265 DRQPYYIVLELLAGGDLQKFLR---EN--------RNTPE------------------------- 1293
            ...|..::.|....|||..|||   ||        .|.||                         
Zfish   657 HGGPVLVITEYCCHGDLLNFLRSKAENFLNFVMTIPNFPEPMTDYKNVSTERMFVRSDSGISSTC 721

  Fly  1294 ------------RPS---------------LLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARN 1331
                        ||:               .|.|.|||..:..||:|..::.:|..||||:||||
Zfish   722 SDHYLDMRPVTSRPTNSALDSSSECQEDSWPLDMDDLLRFSSQVAQGLDFLAAKNCIHRDVAARN 786

  Fly  1332 CLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILL 1396
            .||::   .||.||.|||::|||.....|...|.|.||:|||.||:..:.::|.::||||:||:|
Zfish   787 VLLTN---SRVAKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFECVYTVQSDVWSYGIML 848

  Fly  1397 WEVFSLGRSPYPG-QHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL 1460
            ||:||||:||||. ..:::..:::..|.::..|...|..:|.:|..|||....:||||       
Zfish   849 WEIFSLGKSPYPNILVDSKFYKMIKCGYQMSRPDFAPPEMYTIMKMCWNLDAAERPTF------- 906

  Fly  1461 TACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLVPLPPGGSNNPSMASGSGY 1525
                   |.::..:..:||.| ||:.||       :|:               .|.|:.|..   
Zfish   907 -------SKISQMIQRMLGET-SEQQDT-------QEY---------------KNIPTEAEA--- 938

  Fly  1526 VPELQRQQMSSCTP 1539
                 .||:.||.|
Zfish   939 -----EQQLESCDP 947

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_652600.1 MAM 288..447 CDD:99706
MAM 505..689 CDD:99706
PTKc_ALK_LTK 1186..1462 CDD:270632 112/352 (32%)
csf1raNP_571747.1 Ig_2 41..110 CDD:464026
IG_like 126..200 CDD:214653
Ig 226..306 CDD:472250
Ig strand B 230..234 CDD:409551
Ig strand C 244..248 CDD:409551
Ig strand E 272..276 CDD:409551
Ig strand F 286..291 CDD:409551
Ig strand G 299..302 CDD:409551
Ig 311..410 CDD:472250
Ig strand B 337..341 CDD:409364
Ig strand C 351..354 CDD:409364
Ig strand E 378..382 CDD:409364
Ig strand F 392..397 CDD:409364
Ig strand G 405..408 CDD:409364
Regulatory juxtamembrane domain. /evidence=ECO:0000250 544..576 11/56 (20%)
PTKc_CSF-1R 545..918 CDD:133237 123/421 (29%)
Activation loop. /evidence=ECO:0000250 799..821 9/21 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 919..977 14/60 (23%)
Blue background indicates that the domain is not in the aligned region.

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