DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Alk and alk

DIOPT Version :9

Sequence 1:NP_001261027.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:XP_691964.7 Gene:alk / 563509 ZFINID:ZDB-GENE-031027-1 Length:1705 Species:Danio rerio


Alignment Length:1468 Identity:469/1468 - (31%)
Similarity:640/1468 - (43%) Gaps:313/1468 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 GHFLYARVNPSSRPLNLTSPEFSTTMEKCFLE--VYMH--QSDMSHGLSRVVVELLHTAESSWVP 395
            |.||....:..:.|..| ||.|......|.|:  |::|  ||      .|..|.|:   |....|
Zfish   328 GRFLTVNSSALTGPWVL-SPWFRAAHRPCGLDITVFLHPRQS------GRYTVWLI---ERDKPP 382

  Fly   396 AEIL---GDNVRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHV---ALDNLRMVNCFPEGTK 454
            ..:|   ..:|..|......|...|:.|||      .....|.|.:   ..|.....||   .|:
Zfish   383 LALLTTEHPHVIGWAVVHLSLAARSKPFRI------SSSYSQPGEIETATYDPRYSTNC---TTR 438

  Fly   455 SEKCST--SQVKCTSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGWRDS 517
            |.:..|  .:..|...:.   |::.::||.:.||.:.:||.:.|.:...|..|.|..:.|||:..
Zfish   439 SSQNVTLRGRYHCRGGRE---INVSQLCDFSIDCPQGDDEGEHCRQFLNGSYCSFGREDCGWQPV 500

  Fly   518 GKTTLTWSRH-------TGSSPTH------DTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEK 569
            ......|..|       ..|.|:.      |:.|.|......:::....|               
Zfish   501 QGRGPQWRAHPSIPQSLRSSCPSPGALLAIDSQPKGQRGSAQVRSPLFFY--------------- 550

  Fly   570 NSIIGFASNAIMVSKTFNPPPSVHGNPDSPYRNS-CVVRFFIHQFGKNPGSINLSVVEMKEKENI 633
                                         |.||: |:|:|::  .|.:.|:::|.:.|.......
Zfish   551 -----------------------------PLRNAPCMVKFWV--CGSSNGALSLWITENSTGPEG 584

  Fly   634 TTTLWWSTK--NQGSDWMRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNI-- 694
            ..:||.||.  |.|..|......|..:...:||||.|.:........|||:|:||.||| |..  
Zfish   585 QRSLWNSTSEANMGKGWKLITLPLFGLVDLFYLQFSADISSSSGIAFAVDNFTLSMECF-LETNG 648

  Fly   695 ---------PEDHLGGYNYWDVRQNLKSPTY------KDFEYTNYLELTTCDTRGMIGPSQAQCE 744
                     |...|    :....:|:|:.|.      ...|...:: ..||...|..||:..||.
Zfish   649 EFPPVAPISPTQAL----FTQSNENIKTTTTLYGGPGASTESVKWI-FHTCGATGQDGPTPTQCS 708

  Fly   745 AAYREQNKTHVLREVHV-VEDQSSYKGMQKWKVPHEGHYTIIAKGASGGLGSGGVGSSRGSVAVA 808
            .:||..|       |:| |..:..:||:|.|:||....|.|.|.||:||.....|..|.|.....
Zfish   709 NSYRNTN-------VNVTVGTKGPFKGIQMWQVPETRKYRITAYGAAGGRSVLAVHKSHGVYMTG 766

  Fly   809 ILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFRSKQ-DMVKNIYIENGAG 872
            ...|.|:|.||.||||:||:|| .:|....:..|             |.:| ..:....::.|.|
Zfish   767 DFLLQKDELLYILVGQEGEDAC-PNMVPTMDRIC-------------REQQGPSINKTQLKGGGG 817

  Fly   873 GGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYID--EDFQHGQKAKPLQAPESGQINGEPLN 935
            |||||:|||.:  .....:|||:|.||||.|.....:  |:......:.|.:..:||        
Zfish   818 GGGGGTYVFKV--VNGVHIPLLIAAGGGGRGYSSQSETPEEVMDRDPSIPGRNGKSG-------- 872

  Fly   936 KKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTG 1000
              |||.||||   .|.|..|..|..|:.||:||..|        .::....:||||||||.|..|
Zfish   873 --TAGGGGGW---NDSAPVPQGGRPLILGGQGGEPC--------QAMGWKTRGGFGGGGGACTAG 924

  Fly  1001 GGGGGYAGGDVYL---TESNGEGGSSYISPSRSLREISEIH---AGASSGPGAIIIIPAIEGCGC 1059
            ||||||.||..:.   ...:|:.|:|||||.      .|::   .....|.|.:||.| ::.|. 
Zfish   925 GGGGGYRGGSAWHDNDPRKDGDDGTSYISPD------GEMYLEPLKGMEGNGEVIINP-VQNCS- 981

  Fly  1060 DYRCVALD--EFRSKVRCICPDGWSLKRDNHTAC----EIREEAGKSSFQYLVSILMISLAVLFI 1118
              .|.:.|  |....:.|.|.:..:|..|. .:|    |:.....:.|..:|...|.:..:.|  
Zfish   982 --HCESGDCHETSEGMVCYCDEELTLAPDG-VSCINSTELPLLPAQPSLSHLALGLSVGTSAL-- 1041

  Fly  1119 CIAAL------IFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILN 1177
             ||||      :.::|.|...:.||.:..  |...|.:|::||.:   :.:.::|||| |.|  .
Zfish  1042 -IAALLLAVSGVMIMYRRKHTELQSIQLE--LQSPDCKLSKLRAS---TIMTDYNPNY-CFG--G 1097

  Fly  1178 GHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFL 1242
            ....||.|.:|.|.::.|...||.|||||||..|.....|:...|.||||||.|....:.|.|||
Zfish  1098 KTASVNDLKEVPRRNISLTRGLGHGAFGEVYEGLAVGIPGEPSPMQVAVKTLPEVCSEQDELDFL 1162

  Fly  1243 KEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCA 1307
            .||.|::||:|.|:|..|||.....|::|:|||:|||||:.||||.|...|.||.|||.|||..|
Zfish  1163 MEALIISKFSHQNIVRCIGVSLQALPHFILLELMAGGDLKSFLRETRPRLEHPSSLTMVDLLNIA 1227

  Fly  1308 LDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKW 1372
            .|:|:||:|:|..:|||||||||||||:.||||||.||.||||:|||||:.||||||:||||:||
Zfish  1228 RDIARGCQYLEENQFIHRDIAARNCLLTCKGPGRVAKIGDFGMARDIYRASYYRKGGRAMLPVKW 1292

  Fly  1373 MPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYK 1437
            ||||||::||||||||.||||:||||:||||..|||.:.|.:|:|.|..|||:..|..||..:|:
Zfish  1293 MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSRSNQEVLEFVTNGGRMDPPKNCPGPVYR 1357

  Fly  1438 VMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAV 1502
            :|...|...|||||.|.|:||.:..|.||..::|.|||...||...|.:...:||.:.     :.
Zfish  1358 IMTQSWQHQPEDRPNFSTILERIDYCLQDPDVVNVPLPVEYGPIPEEEERVPMRPEDP-----SA 1417

  Fly  1503 PDYLVPLPPGGSNNPS-----MASGSGYVPELQRQQMSSCTPPAVTSPAAPHPR----------P 1552
            |..||. |.|..:.||     .:...|....:......|..||  ..|:.|||.          |
Zfish  1418 PSLLVS-PQGTEDVPSATHSAQSKKDGEAIHMANLSTDSKLPP--VPPSQPHPHHHLQTPVVTAP 1479

  Fly  1553 VENIAPTS-------GDCWETSFILPNSKVEP-----------PVVG------------------ 1581
            |....|:|       |......|:..:|..:.           |..|                  
Zfish  1480 VPASKPSSTTSNAQDGGHVNLGFMQAHSSEKESRNRKPTNLWNPTYGSWFLQQQQKRQQVQAQRQ 1544

  Fly  1582 -SGHDVPLAGGEE-------AKLISLD--------------------------------TPQPTP 1606
             ||..:|..|.|:       |:.:.|.                                .|.|.|
Zfish  1545 TSGPRIPGEGQEQVGRTVTVAEALGLQQQHKQQQYQQQLQRQQQQQQQQQQQQGLCRPLLPPPPP 1609

  Fly  1607 TTIQPPLSFASQLDGITLDPSAL--TKSLPNGNAKQSY 1642
            ....|.|     ||..||.|..|  .:..|.||....|
Zfish  1610 PAPTPLL-----LDSATLAPVPLYRLRRFPCGNIGYGY 1642

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_001261027.1 MAM 288..450 CDD:279023 32/124 (26%)
MAM 288..447 CDD:99706 30/121 (25%)
MAM 505..691 CDD:279023 44/201 (22%)
MAM 505..689 CDD:99706 42/199 (21%)
PTKc_ALK_LTK 1186..1462 CDD:270632 161/275 (59%)
TyrKc 1193..1460 CDD:197581 159/266 (60%)
alkXP_691964.7 LDLa 449..475 CDD:197566 6/28 (21%)
MAM 488..639 CDD:99706 40/196 (20%)
FXa_inhibition 980..1012 CDD:317114 8/35 (23%)
PTKc_ALK_LTK 1106..1382 CDD:270632 161/275 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 333 1.000 Domainoid score I1110
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D27151at33208
OrthoFinder 1 1.000 - - FOG0002954
OrthoInspector 1 1.000 - - otm26022
orthoMCL 1 0.900 - - OOG6_105014
Panther 1 1.100 - - LDO PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.920

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