DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and Cad96Ca

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	432	Identity:	133/432 - (30%)
Similarity:	207/432 - (47%)	Gaps:	88/432 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1109 LMISLAVLFICIAALIFMLYNR------------YQRKKQSKK--------------RHKMLVEQ 1147
            :::::...|:.||.|:..|..|            .::::.:||              |:.|:::|
  Fly   318 IVVTVGGFFVAIAVLLAYLCRRRLCAISRTLKKTKEKEELAKKSNQSQLSSTLTDDSRNSMVMQQ 382

  Fly  1148 ----------------DLQL----TRLRNNIDDSNL--------------NNFNPNYGCDGILNG 1178
                            |.|:    ::|...:.:..:              :|..|  ||   |.|
  Fly   383 WQGPVAFANRYVPWERDQQMGIATSQLSTGVTNGGVSSPGVPSPGTGEPGSNLGP--GC---LTG 442

  Fly  1179 HIDVNSLPQVA-------------RDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLR 1230
            ....:..|:.|             |..|:..|.||:||||:|:.....:.:|:.....||||||:
  Fly   443 GAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLK 507

  Fly  1231 EDPKREKEEDFLKEAAIMAKFN-HPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENR----- 1289
            |.......:|.|.|..:|.... |.|:|||:|.|.|:.|.:::||.:..|.||.:||.:|
  Fly   508 ESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERHY 572

  Fly  1290 -NTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRD 1353
             ||..:.::||..||......||||..|:.|:..||||:||||.|::.   ....|:||||.:||
  Fly   573 GNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITD---DHTCKVADFGFARD 634

  Fly  1354 IYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMEL 1418
            :..|..|.:..:..|||:||..|:..|.||:.|:|:||||||:||:.:||.:||||.....||..
  Fly   635 VITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRK 699

  Fly  1419 VVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL 1460
            |..|.||..|..|...:|.:|..||:..|::||.|..:::.|
  Fly   700 VRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQML 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	113/295 (38%)
		TyrKc	1193..1460	CDD:197581	109/273 (40%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	109/273 (40%)
		PTKc	474..742	CDD:270623	109/271 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455359
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940