DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Alk and LTK

DIOPT Version :9

Sequence 1:NP_001261027.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:XP_016877670.1 Gene:LTK / 4058 HGNCID:6721 Length:885 Species:Homo sapiens


Alignment Length:860 Identity:336/860 - (39%)
Similarity:459/860 - (53%) Gaps:113/860 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   728 TTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYKGMQKWKVPHEGHYTIIAKGASGG 792
            :||...|..||:|.||:.||.   .|.|   |..|......:|:|.|:||..|.|.|.|.||:||
Human    71 STCGASGRHGPTQTQCDGAYA---GTSV---VVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGG 129

  Fly   793 LGS-GGVGSSRGSVAVAILELHKNEELYFLVGQQGENAC-----IKSMGVLKEAGCGTDHDLDLA 851
            .|: ..:..:.|....||..|...|.||.|||||||:||     ...:..|.|:....:|     
Human   130 KGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCLGESRAVEEH----- 189

  Fly   852 QYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQ 916
             .:....:.:..:.....|.|||||.:|||.:...:.|  |||||.||||..   |:....:...
Human   190 -AAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELE--PLLVAAGGGGRA---YLRPRDRGRT 248

  Fly   917 KAKP------LQAPESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVEL 975
            :|.|      .:||.||...|      .||.||||.::   |.||..|.:|.:|..||..|....
Human   249 QASPEKLENRSEAPGSGGRGG------AAGGGGGWTSR---APSPQAGRSLQEGAEGGQGCSEAW 304

  Fly   976 ADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVYLTE---SNGEGGSSYISPSRSLREISEI 1037
            |..|.:    ..||||||||.|..|||||||.|||...|:   ::||.|.|:|.||      ||:
Human   305 ATLGWA----AAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPS------SEL 359

  Fly  1038 HAGASSGPGAIIIIPAIEGCG---------CDYRCVALD-EFRSKVR---CICPDGWSLKRDNHT 1089
            ..    .|.|::::...|..|         |.: |...| :::::::   |:||:|..|..||.|
Human   360 FL----QPLAVLLLTVTENHGEVEIRRHLNCSH-CPLRDCQWQAELQLAECLCPEGMELAVDNVT 419

  Fly  1090 ACEIREEAGKSSFQYLVSILMIS-LAVLFICIAALIF------------MLYNRYQRKKQSKKRH 1141
            ..::.:..|  ....:|:::..| |::|.:| ..||.            :|.:..|:|.|..:..
Human   420 CMDLHKPPG--PLVLMVAVVATSTLSLLMVC-GVLILGTKRLAGTVDSRLLLSMKQKKWQGLQEM 481

  Fly  1142 KMLVEQDLQLTRLRNNIDDSNLNNF-NPNYGCDGILNGHIDVNSLP----QVARDSLQLVNALGK 1201
            : |...:|:|::||.    |.:... ||.|...|:  |......||    :|:..::.|:.|||.
Human   482 R-LPSPELELSKLRT----SAIRTAPNPYYCQVGL--GPAQSWPLPPGVTEVSPANVTLLRALGH 539

  Fly  1202 GAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDR 1266
            |||||||..|.....||:..:.||:|||.|....:.|.|||.||.|::||.|.|:|..:|:....
Human   540 GAFGEVYEGLVIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRA 604

  Fly  1267 QPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARN 1331
            .|..|:|||::|||::.|||.:|....:||.|.|:|||..|.|:|:||.|:|...||||||||||
Human   605 TPRLILLELMSGGDMKSFLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARN 669

  Fly  1332 CLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILL 1396
            ||||..||.||.||.||||:|||||:.|||:|.:|:||:|||||||||:||||||||.||||:||
Human   670 CLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLL 734

  Fly  1397 WEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLT 1461
            ||:||||..||||:.|.:|::.||.|||:..|..||..:|::|..||...||.||:|.::||.|.
Human   735 WEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQ 799

  Fly  1462 ACTQDASIMNAPLPNILGPTASE--------RDDTVIRPPNGEEFCLAVPDYL-----VPLPPGG 1513
            .||||..::|:.||..||||..|        |....:|||..:|..   |:.|     .||.|..
Human   800 YCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELS---PEKLKSWGGSPLGPWL 861

  Fly  1514 SNNPSMASGSGYVPE 1528
            |:........|..|:
Human   862 SSGLKPLKSRGLQPQ 876

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_001261027.1 MAM 288..450 CDD:279023
MAM 288..447 CDD:99706
MAM 505..691 CDD:279023
MAM 505..689 CDD:99706
PTKc_ALK_LTK 1186..1462 CDD:270632 152/279 (54%)
TyrKc 1193..1460 CDD:197581 149/266 (56%)
LTKXP_016877670.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 329 1.000 Domainoid score I1157
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 631 1.000 Inparanoid score I847
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D27151at33208
OrthoFinder 1 1.000 - - FOG0002954
OrthoInspector 1 1.000 - - otm42222
orthoMCL 1 0.900 - - OOG6_105014
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3599
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.860

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