DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and Tie

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	124/472 - (26%)
Similarity:	198/472 - (41%)	Gaps:	140/472 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1105 LVSILMISLAVLFICIAALIFMLYNRY---QRKKQSKKRHKMLVEQD-----------LQLTRLR 1155
            ||:::::::.|  |.:||:|..|...:   :|.|||:.....:.:|.           .|:....
  Fly   727 LVTLVLVAVGV--IPLAAIILYLVRNFVIRRRAKQSEVFDVCITDQQPISPVKKVDSKYQVDDDE 789

  Fly  1156 NNID---------------------------------DSNLNNFNPNYGCDGILNGHIDVNSLPQ 1187
            :.:|                                 |:|.|.:..|.....:.:...|..
  Fly   790 DEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQASQRDANHNRYGNNDDKTSLASEFHDFE---- 850

  Fly  1188 VARDSLQLVNALGKGAFGEVYMA----LYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIM 1248
              |.:::|.:.||:|.||:|:.|    |..|.....:   |||||:|....:...:|   ||.||
  Fly   851 --RSNIRLKSLLGEGNFGQVWKAEADDLSGHFGATRI---VAVKTIRACSAQVSLKD---EANIM 907

  Fly  1249 AKF-NHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENR--------NTPERPSL--LTMKD 1302
            .|. :|.|:|.|:|.|.:.:|:.:::|....|.|...||..|        :.|...||  |:.:.
  Fly   908 RKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSATNILPASVPGGRSLAPLSPRT 972

  Fly  1303 LLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDI------------- 1354
            |...|||:|.|..|:..:|.:|||:||||.||...|   :.||.|||||.|:
  Fly   973 LAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNG---MCKICDFGMSIDLDAERMRKEQEKNA 1034

  Fly  1355 -----------YRSDYYRK-------------------------------------GGKAMLPIK 1371
                       ::.|:..:                                     |.:..|||:
  Fly  1035 ANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIR 1099

  Fly  1372 WMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIY 1436
            ||.||:....:||::||:|:|||:|||:.:||.:||......:|:..|.:|.|...|.|.....|
  Fly  1100 WMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFY 1164

  Fly  1437 KVMADCWNPTPEDRPTF 1453
            .:|:.||:..|..||:|
  Fly  1165 NLMSRCWHKEPHMRPSF 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	104/344 (30%)
		TyrKc	1193..1460	CDD:197581	103/337 (31%)
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	103/337 (31%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	102/331 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455325
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940