DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Alk and KDR

DIOPT Version :10

Sequence 1:NP_652600.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:NP_002244.1 Gene:KDR / 3791 HGNCID:6307 Length:1356 Species:Homo sapiens


Alignment Length:1469 Identity:309/1469 - (21%)
Similarity:476/1469 - (32%) Gaps:578/1469 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   619 SINLSVVEMKEKENITTTL-------WWSTKNQGSDWMRAEY----------------VLPNITS 660
            ||...::.:|....:..|.       |....||.....|.|.                |:.|.|.
Human    35 SIQKDILTIKANTTLQITCRGQRDLDWLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTG 99

  Fly   661 KYYLQF-EARMGMRIYSDVAVDDF------SLSPE-----------------CFG----LNI--- 694
            .|...: |..:...||  |.|.|:      |:|.:                 |.|    ||:   
Human   100 AYKCFYRETDLASVIY--VYVQDYRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLC 162

  Fly   695 ---PEDHL---GGYNYWDVRQNLKSPTYKDFEYTNYLELTTCDTR-------------------- 733
               ||...   |....||.::....|:|    ..:|..:..|:.:                    
Human   163 ARYPEKRFVPDGNRISWDSKKGFTIPSY----MISYAGMVFCEAKINDESYQSIMYIVVVVGYRI 223

  Fly   734 --GMIGPSQA-----------QCEA---------------AYREQNKTHVLREVHVVEDQSSYKG 770
              .::.||..           .|.|               :.:.|:|..|.|::.........|.
Human   224 YDVVLSPSHGIELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKF 288

  Fly   771 MQKWKV-----PHEGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFLVGQQ----- 825
            :....:     ..:|.||..|        |.|:.:.:.|..|.:   |:...:.|..|.:     
Human   289 LSTLTIDGVTRSDQGLYTCAA--------SSGLMTKKNSTFVRV---HEKPFVAFGSGMESLVEA 342

  Fly   826 --GENACIKSM--------------GVLKEAG--CGTDHDLDLAQYSFRSKQDMVKNIYIENGAG 872
              ||...|.:.              |:..|:.  ....|.|.:.:.|.|..              
Human   343 TVGERVRIPAKYLGYPPPEIKWYKNGIPLESNHTIKAGHVLTIMEVSERDT-------------- 393

  Fly   873 GGGGGSYVFLL-----NQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKA--KPLQAPESG--- 927
                |:|..:|     .:.::..|.|:|           |:..  |.|:|:  .|:.:.:.|   
Human   394 ----GNYTVILTNPISKEKQSHVVSLVV-----------YVPP--QIGEKSLISPVDSYQYGTTQ 441

  Fly   928 -------------------QINGEPLNKKTAG-------PGGGWRAKEDQALSPTYGA------- 959
                               |:..|..|:.:..       |...||:.||     ..|.       
Human   442 TLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVED-----FQGGNKIEVNK 501

  Fly   960 ---ALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGGC---NTGGGGGGY------AGGDVY 1012
               ||::|.....|..|..|.|.:::::            |   |..|.|...      .|.::.
Human   502 NQFALIEGKNKTVSTLVIQAANVSALYK------------CEAVNKVGRGERVISFHVTRGPEIT 554

  Fly  1013 L------TESNGEGGSSYISPSRSLRE----------ISEIHAGA-------------------- 1041
            |      ||.  |..|.:.:..||..|          ...||.|.                    
Human   555 LQPDMQPTEQ--ESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMF 617

  Fly  1042 SSGPGAIIII----PAIEGCGCDYRCVALDEFRSKVRCICPD----------------------G 1080
            |:....|:|:    .:::..| ||.|:|.|....|..|:...                      |
Human   618 SNSTNDILIMELKNASLQDQG-DYVCLAQDRKTKKRHCVVRQLTVLERVAPTITGNLENQTTSIG 681

  Fly  1081 WSLK----------------RDNHTACE-----------------IREE---------------- 1096
            .|::                :||.|..|                 :|:|                
Human   682 ESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDEGLYTCQACSVLGCA 746

  Fly  1097 --------AGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTR 1153
                    .|......|..|:::..||:.:....|:.::....:|....:.:             
Human   747 KVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLLVIILRTVKRANGGELK------------- 798

  Fly  1154 LRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLP---------------QVARDSLQLVNALGKGA 1203
                               .|.|:..:|.:.||               :..||.|:|...||:||
Human   799 -------------------TGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGRGA 844

  Fly  1204 FGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKF-NHPNMVHLIGVCF-DR 1266
            ||:|..|.....|..|....||||.|:|.....:....:.|..|:... :|.|:|:|:|.|. ..
Human   845 FGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPG 909

  Fly  1267 QPYYIVLELLAGGDLQKFLRENRN--TP------------------------------------- 1292
            .|..:::|....|:|..:||..||  .|                                     
Human   910 GPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSAS 974

  Fly  1293 ----ERPSL----------------LTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSK 1337
                |..||                ||::.|:..:..||||..::.|::.||||:||||.|||.|
Human   975 SGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEK 1039

  Fly  1338 GPGRVVKIADFGMSRDIYRS-DYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFS 1401
               .||||.|||::||||:. ||.|| |.|.||:|||.||...|.::|.::||||||:||||:||
Human  1040 ---NVVKICDFGLARDIYKDPDYVRK-GDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFS 1100

  Fly  1402 LGRSPYPG-QHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQ 1465
            ||.||||| :.:.:....:..|.|:.:|......:|:.|.|||:..|..||||..|:||      
Human  1101 LGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH------ 1159

  Fly  1466 DASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLVPLPPGGSNNPSMASGSGYVPELQ 1530
                    |.|:|...|.:         :|:       ||:| ||.  |...||...||.  .|.
Human  1160 --------LGNLLQANAQQ---------DGK-------DYIV-LPI--SETLSMEEDSGL--SLP 1195

  Fly  1531 RQQMSSCTPPAVTSPAAPHPRPVENIAPTSGDCWETSFILPNS--KVEPPVVGSGHDVPLAGGEE 1593
            ...:|......|..|...:..       |:|    .|..|.||  |..|..|.:..|:||. ..|
Human  1196 TSPVSCMEEEEVCDPKFHYDN-------TAG----ISQYLQNSKRKSRPVSVKTFEDIPLE-EPE 1248

  Fly  1594 AKLISLDTPQPTPT------------TIQPPLSFASQLDGITLDPSALTKSLPNGNAKQSY---- 1642
            .|:|    |....|            |::.....:....|:.  ||...:|:.:..:.|:.    
Human  1249 VKVI----PDDNQTDSGMVLASEELKTLEDRTKLSPSFGGMV--PSKSRESVASEGSNQTSGYQS 1307

  Fly  1643 ------ANVQVKNEAEAKVINGV-VGNGTVMNGDVSTGS 1674
                  .:..|.:..||:::..: :|        |.|||
Human  1308 GYHSDDTDTTVYSSEEAELLKLIEIG--------VQTGS 1338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_652600.1 MAM 288..447 CDD:99706
MAM 505..689 CDD:99706 21/116 (18%)
PTKc_ALK_LTK 1186..1462 CDD:270632 122/353 (35%)
KDRNP_002244.1 IgI_VEGFR 224..326 CDD:409448 17/112 (15%)
Ig strand A 224..228 CDD:409448 0/3 (0%)
Ig strand A' 234..238 CDD:409448 0/3 (0%)
Ig strand B 240..249 CDD:409448 1/8 (13%)
Ig strand C 256..261 CDD:409448 0/4 (0%)
Ig strand C' 264..266 CDD:409448 0/1 (0%)
Ig strand D 270..278 CDD:409448 3/7 (43%)
Ig strand E 286..294 CDD:409448 1/7 (14%)
Ig strand F 304..310 CDD:409448 3/13 (23%)
Ig strand G 315..321 CDD:409448 1/5 (20%)
IgI_VEGFR-2 329..417 CDD:409450 16/105 (15%)
Ig strand A 329..332 CDD:409450 0/2 (0%)
Ig strand A' 339..343 CDD:409450 0/3 (0%)
Ig strand B 345..356 CDD:409450 3/10 (30%)
Ig strand C 360..366 CDD:409450 0/5 (0%)
Ig strand C' 368..371 CDD:409450 1/2 (50%)
Ig strand D 376..379 CDD:409450 0/2 (0%)
Ig strand E 381..386 CDD:409450 2/4 (50%)
Ig strand F 394..402 CDD:409450 3/7 (43%)
Ig strand G 408..417 CDD:409450 2/8 (25%)
IG_like 565..661 CDD:214653 19/96 (20%)
I-set 667..754 CDD:400151 8/86 (9%)
Ig strand B 684..688 CDD:409353 0/3 (0%)
Ig strand C 697..701 CDD:409353 0/3 (0%)
Ig strand E 720..724 CDD:409353 0/3 (0%)
Ig strand F 734..739 CDD:409353 0/4 (0%)
VEGFR-2_TMD 759..793 CDD:375470 6/33 (18%)
PTKc_VEGFR2 826..1167 CDD:270681 124/358 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1318 5/45 (11%)
Blue background indicates that the domain is not in the aligned region.

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