DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Alk and Egfr

DIOPT Version :9

Sequence 1:NP_001261027.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:NP_476759.1 Gene:Egfr / 37455 FlyBaseID:FBgn0003731 Length:1426 Species:Drosophila melanogaster


Alignment Length:1546 Identity:313/1546 - (20%)
Similarity:500/1546 - (32%) Gaps:549/1546 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   390 ESSWVPAEILG----DNVRQWT-----------RKVYRLGRVSRDFRIVFEV------------- 426
            |.:|:|.|.|.    ||:|:.|           :.|:...::.|. |.:|.:             
  Fly   137 ELTWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRG-RTLFSLSVEEEKYALFVTY 200

  Fly   427 -------VPDLRVGQKGHVALDN------LRMV-------------------------------- 446
                   :||||....|.|...|      :|.:                                
  Fly   201 SKMYTLEIPDLRDVLNGQVGFHNNYNLCHMRTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESC 265

  Fly   447 --NCFPEGTK----------SEKCSTSQVKCTSSKVPVCIHLPRIC------DITRDCDEAE--- 490
              .|:.||.|          |.:|:..  :|...|...|.||  .|      ...:||...:   
  Fly   266 THGCWGEGPKNCQKFSKLTCSPQCAGG--RCYGPKPRECCHL--FCAGGCTGPTQKDCIACKNFF 326

  Fly   491 DE---QQSC------------------DKIPYGGRCDFEEDWCGWRDSGKTTLTWSR---HTGSS 531
            ||   ::.|                  .|..||..|..|......||:|....:..:   ..|..
  Fly   327 DEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPGHLLRDNGACVRSCPQDKMDKGGE 391

  Fly   532 PTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNN--SEKNSIIGFASNAIMVSKTFNPPPSVHG 594
            .....||        ......|..:|     |..|  |.:|..: ...|..::.:||:....|:.
  Fly   392 CVPCNGP--------CPKTCPGVTVL-----HAGNIDSFRNCTV-IDGNIRILDQTFSGFQDVYA 442

  Fly   595 N--------PDSPYRNSCV-----VRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGS 646
            |        |..|.|....     :..:::..|.:|...|||..     .|:.|.       .|.
  Fly   443 NYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYF-----RNLETI-------HGR 495

  Fly   647 DWMRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNI--------PEDHLGGYN 703
            ..|.:.:....|........|.|...:|.|...|...: ...|:..||        ||..:    
  Fly   496 QLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHN-RDLCYVSNIRWPAIQKEPEQKV---- 555

  Fly   704 YWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQC-------------------EAAYRE 749
             | |.:||::..   .|....:....|:..|..|....||                   ..||:.
  Fly   556 -W-VNENLRADL---CEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADCGYISNAYKF 615

  Fly   750 QNKT-----------------HVLREVHVVEDQSSYKGMQKWK-----VPHEGHYTIIAKGASGG 792
            .|:|                 |....|||.:.|.......|.|     |..|.|.|  ..|.:|.
  Fly   616 DNRTCKICHPECRTCNGAGADHCQECVHVRDGQHCVSECPKNKYNDRGVCRECHAT--CDGCTGP 678

  Fly   793 LGSGGVG----------SSRGSVAVAILELHKNEELYF--------------LVGQ--------- 824
            ..:.|:|          ::..:|...:|:..|..:.||              |.|:         
  Fly   679 KDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPL 743

  Fly   825 --------QGENACIKSMGVLK----EAGCGTDHDLDLAQYS-FRSKQDMVKNIYIENGAGGGGG 876
                    ..|..|.|.....:    |..|..||..|..|.. |:...:.       ||..|.|.
  Fly   744 CELCTNYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPEC-------NGCTGPGA 801

  Fly   877 GSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAKPLQAPESG-QINGEPLNKKTAG 940
                                             :|.:..:..|...|.|:| .:|....|..:  
  Fly   802 ---------------------------------DDCKSCRNFKLFDANETGPYVNSTMFNCTS-- 831

  Fly   941 PGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGG 1005
                                         .|.:|:        ||....:...|..|..      
  Fly   832 -----------------------------KCPLEM--------RHVNYQYTAIGPYCAA------ 853

  Fly  1006 YAGGDVYLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFR 1070
                                ||.||    |:|.|...     :.:|..|.|.             
  Fly   854 --------------------SPPRS----SKITANLD-----VNMIFIITGA------------- 876

  Fly  1071 SKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKK 1135
                                             .||..:.|...|.:||             |:|
  Fly   877 ---------------------------------VLVPTICILCVVTYIC-------------RQK 895

  Fly  1136 QSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLP-QVARDS-LQLVNA 1198
            |..|:      :.:::|...:..:||           :.:...:|..|... ::.:|: |:....
  Fly   896 QKAKK------ETVKMTMALSGCEDS-----------EPLRPSNIGANLCKLRIVKDAELRKGGV 943

  Fly  1199 LGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVC 1263
            ||.||||.||..:: ..:|:.|::.||:|.|.:....|..|:||:||.|||...|.|::.|:.||
  Fly   944 LGMGAFGRVYKGVW-VPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVC 1007

  Fly  1264 FDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIA 1328
            ...| ..::.:|:..|.|..::|.||:.      :..|.||..:..:|||..|:|.||.:|||:|
  Fly  1008 MSSQ-MMLITQLMPLGCLLDYVRNNRDK------IGSKALLNWSTQIAKGMSYLEEKRLVHRDLA 1065

  Fly  1329 ARNCLLSSKGPGRVVKIADFGMSRDIYRSD---YYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVW 1390
            |||.|:.:..   :|||.|||::: :..||   |...|||  :||||:..|...:.:||||:|||
  Fly  1066 ARNVLVQTPS---LVKITDFGLAK-LLSSDSNEYKAAGGK--MPIKWLALECIRNRVFTSKSDVW 1124

  Fly  1391 SFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFIT 1455
            :||:.:||:.:.|:.|:.......:.:|:..|.:|..|..|.:.||..:..||:.....||||..
  Fly  1125 AFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQ 1189

  Fly  1456 LLEHLTACTQD----ASIMNAPLPNILGPTASERDDTV--IRPPNGEEFCLAVP-DYLVP-LPPG 1512
            |........:|    .:|.......:...|:.:..|.:  :.|.......:|.| |||.| ..||
  Fly  1190 LTTVFAEFARDPGRYLAIPGDKFTRLPAYTSQDEKDLIRKLAPTTDGSEAIAEPDDYLQPKAAPG 1254

  Fly  1513 GSNNPSMASGSGYVPELQR-----QQMSSCTPPAVTSPAAPH--------PRPVENIAPTSGDCW 1564
            .|:....   :..:|:|.|     ...:|.|....|..:|..        ..||:          
  Fly  1255 PSHRTDC---TDEIPKLNRYCKDPSNKNSSTGDDETDSSAREVGVGNLRLDLPVD---------- 1306

  Fly  1565 ETSFILP--------NSKVEPPVVGSGHDVPLAGGEEAKL---ISLDTPQ-------------PT 1605
            |..:::|        |:.:..|...:...|.:|.|....:   :|:|.|:             |.
  Fly  1307 EDDYLMPTCQPGPNNNNNINNPNQNNMAAVGVAAGYMDLIGVPVSVDNPEYLLNAQTLGVGESPI 1371

  Fly  1606 PT-TIQPPLSFASQLDGITLDPSALTKSLPNGNAKQSYANVQVKNEAEAKV 1655
            || ||..|:.      |:   |..:...:|...::.:.::.:..|:.:.::
  Fly  1372 PTQTIGIPVM------GV---PGTMEVKVPMPGSEPTSSDHEYYNDTQREL 1413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_001261027.1 MAM 288..450 CDD:279023 22/134 (16%)
MAM 288..447 CDD:99706 21/131 (16%)
MAM 505..691 CDD:279023 38/203 (19%)
MAM 505..689 CDD:99706 37/201 (18%)
PTKc_ALK_LTK 1186..1462 CDD:270632 99/280 (35%)
TyrKc 1193..1460 CDD:197581 98/269 (36%)
EgfrNP_476759.1 Recep_L_domain 419..547 CDD:279382 27/141 (19%)
GF_recep_IV 572..684 CDD:291509 22/113 (19%)
FU 573..>606 CDD:238021 5/32 (16%)
FU 617..659 CDD:214589 8/41 (20%)
FU 662..716 CDD:214589 11/55 (20%)
FU 739..786 CDD:238021 9/46 (20%)
FU 784..834 CDD:214589 12/120 (10%)
PTKc_EGFR_like 930..1208 CDD:270648 100/291 (34%)
STYKc 938..1194 CDD:214568 98/269 (36%)
Recep_L_domain 128..239 CDD:279382 21/102 (21%)
Furin-like 253..401 CDD:279142 28/159 (18%)
FU 255..292 CDD:214589 6/36 (17%)
FU 302..345 CDD:238021 9/44 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455334
Domainoid 1 1.000 165 1.000 Domainoid score I1208
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.940

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