DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and dnt

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_001260567.1	Gene:	dnt / 35207	FlyBaseID:	FBgn0024245	Length:	584	Species:	Drosophila melanogaster

Alignment Length:	433	Identity:	102/433 - (23%)
Similarity:	185/433 - (42%)	Gaps:	82/433 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1069 FRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILM-----------ISLAVLFICIAA 1122
            ||.|..|:.         |.:|.::.|:....  |.|.::::           :|:|:..:|:
  Fly   174 FRRKKICLM---------NDSAEDLSEDVDDP--QLLETVMLPPTGLITLVVGVSVAMGSVCL-- 225

  Fly  1123 LIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILN---------- 1177
            |:.:.|  ..:...:|::|.....|.::         .|:....|.:..|...:.
  Fly   226 LLMIAY--CVKGAANKRQHHQHGGQPMR---------TSSFQRLNTHPPCQSSMGSAAYMTPSII 279

  Fly  1178 GHIDVNSLPQ----------------------VARDSLQLVNALGKGAFGEVYMALYRHRDGDAV 1220
            ..|..:|||:                      |.|..::|.:.|.:|.||.||...|..
  Fly   280 APIHGSSLPRKVPVSVEQQHPEELHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYND------ 338

  Fly  1221 EMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFD--RQPYYIVLELLAGGDLQK 1283
            ...|.|||:.:...:.:....|:|..::...:||.::.::||..:  ..|:.:...|....:|::
  Fly   339 TQDVLVKTVAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQ 403

  Fly  1284 FLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADF 1348
            ||.:    |.....:|...::..|..::....::.|...:|:|||.|||::..:   ..||::|.
  Fly   404 FLLD----PACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQ---LRVKLSDS 461

  Fly  1349 GMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNT 1413
            .:|||::.|||...|.....|:|||..||.....|:..:|.|:||:|:||:.:..:.||......
  Fly   462 SLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAEVDPF 526

  Fly  1414 QVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITL 1456
            ::...:..|.||..|..||..::.:||.||...|.:||||..|
  Fly   527 EMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	79/295 (27%)
		TyrKc	1193..1460	CDD:197581	76/266 (29%)
dnt	NP_001260567.1	WIF	46..182	CDD:128745	4/7 (57%)
		PKc_like	310..580	CDD:304357	78/273 (29%)
		Pkinase_Tyr	317..573	CDD:285015	76/266 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455370
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940