DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Alk and Pvr

DIOPT Version :10

Sequence 1:NP_652600.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster


Alignment Length:1799 Identity:367/1799 - (20%)
Similarity:566/1799 - (31%) Gaps:754/1799 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 DPLQEIKDRIRDTSPNANTYAPHTD-------ATPSSEYEYELGVKCNFETPCSWTWGNYSD--G 304
            ||..::.|     |.|..|...:||       |.|.:|...|..   |.|...|.:.|.|..  |
  Fly   155 DPDTKLVD-----SHNVVTARQYTDVVIPCKPAMPDTEVLLETS---NGEMHSSKSVGRYDPQRG 211

  Fly   305 FQVITGTELSKRNLTGLLPGPAADSIDDANGHFLYARVNPSSRPLNLTSPEFSTTMEKCFLE--- 366
            |.:    |:.              ||.|...:  |.|.||.. |.|   .|..|::|..|:.   
  Fly   212 FTI----EIR--------------SIVDGGDY--YCRPNPPF-PHN---EEEMTSIEVRFIATGL 252

  Fly   367 ----------VYMHQSDMSHGLSRVVVELLHTAESSWVPAEILGDNVRQWTRKVYRLGRVSRD-- 419
                      ||.:...::.|...|   |..|.:|:...|.|.|.:           |.:||:  
  Fly   253 DIPRTQTTNMVYTYAPGVTDGDDEV---LTVTNQSTGNLALIRGGD-----------GTLSRERA 303

  Fly   420 ----FRIV-FEVVPDLRVGQKG--------------HVALDNLRMVNCFPEGTKSEKCSTSQVKC 465
                .|:. ....|..|.||.|              ||..|.                       
  Fly   304 RRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDT----------------------- 345

  Fly   466 TSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDW-CGWRDSGKTTLTWSR--- 526
                           :.|.||     ||.:..:..||      .:| ...||..:...:.||   
  Fly   346 ---------------NFTLDC-----EQSAYVESVYG------MEWFTPSRDENRIFASQSRTDP 384

  Fly   527 HTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLV---NMNQHM------------NNSEKN------ 570
            .|.:| ||.|| ....|:.:.|.:.:|.|..|   |.||::            |.|..|      
  Fly   385 KTRNS-THQTG-RSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSG 447

  Fly   571 --SIIGFASNAIMVSKTFN--PPPSVHG-NPDSPYRNSCVVRFFIHQFGKNPGSINLSVVEMKEK 630
              ::..:|:..|.::..|.  |.||... .||.                          .|:::.
  Fly   448 HYNVQEYANRTIQMTANFEGFPTPSFSWFKPDG--------------------------TEVRQS 486

  Fly   631 EN----ITTTLWWSTKNQ---------------GSD---WMRAEYVLPNIT---------SKYYL 664
            ||    ::|.|  ||..|               ||:   .::.||   |::         |..|:
  Fly   487 ENNFKILSTEL--STMLQVLNAQLQDSGTYVLRGSNSFGVVQREY---NVSVMDAPALKMSDAYV 546

  Fly   665 QF--EARM--GMRIYSDVAVDDF----SLSPE---CFGLNIPEDHLGGYNYWDVRQNLKSPTYKD 718
            |.  .||:  .:|.|....|..|    ||.|:   |..||               ||...|:.::
  Fly   547 QVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLN---------------QNFSLPSEQE 596

  Fly   719 -FEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYKGMQKWKVPHE-GH 781
             :::         .||..  |.:...|..|                 :.|:       :|.| |.
  Fly   597 KYQF---------QTRPR--PGKLSVERIY-----------------EVSF-------LPTEPGI 626

  Fly   782 YTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDH 846
            .|.||:....       |..|.::..|          :.|:|...||..|        .|...||
  Fly   627 LTCIAQNIID-------GKERRTLTKA----------HVLLGNISENMTI--------YGFDKDH 666

  Fly   847 DLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDED 911
            .:        :|:|.| |...|                                  .:..:.|.:
  Fly   667 KI--------AKEDNV-NFTCE----------------------------------ALAYHFDGN 688

  Fly   912 ---FQHGQKAKPLQAPESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYV 973
               |.:|:..|     ||..::.|..:.|.:            ..|..:...:....||.:.|..
  Fly   689 LKWFINGEDLK-----ESDSVHIETSHTKYS------------YKSTVHITTISDRDRGTYECRA 736

  Fly   974 ELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGG--DVYLTE-------SNGEGGSSYISPSR 1029
            ...|....                        |:..  |:|:.:       :.|:.|.|.|  .|
  Fly   737 YHNDKDAV------------------------YSSREIDLYVHDPSAPQWTNGGQEGHSKI--KR 775

  Fly  1030 SLREISEIHAGASSGPGAII----------------------------IIPAIEGCGCDYRCVAL 1066
            .|.:..|:...:::.|.||:                            :.|..||.   |:||. 
  Fly   776 KLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGV---YKCVV- 836

  Fly  1067 DEFRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILM-ISLA------VLFICIAALI 1124
                                     |.|.:..:.||..::|.|. ||:|      :||:.:..|.
  Fly   837 -------------------------ENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLC 876

  Fly  1125 FMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLP--- 1186
            ..|..|||::   .|||..|....|.      |.::..:.:.||:...|.      ....||   
  Fly   877 VFLAVRYQKE---HKRHLALKAAGLA------NFEEGAVGHINPDLTLDE------QAELLPYNR 926

  Fly  1187 --QVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMA 1249
              :..|::|:|...||.||||.|.....:....:.....||||.::.....|.....:.|..||.
  Fly   927 EFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMV 991

  Fly  1250 KF-NHPNMVHLIGVC---FDRQPYYIVLELLAGGDLQKFLRENRN------TPER----PSLLTM 1300
            .. .|.|:|:|:|..   ..::...:::|....|::|.||..||.      .|:.    ||::|.
  Fly   992 HLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQ 1056

  Fly  1301 K---------------------------------------------------------------- 1301
            :                                                                
  Fly  1057 RMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTA 1121

  Fly  1302 ---------------------------------------------------DLLFCALDVAKGCR 1315
                                                               ||:..|..||:|..
  Fly  1122 TYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMD 1186

  Fly  1316 YMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLD 1380
            |:.||:.:|.|:||||.||..   ..||||.|||::|.:||.|.|:|.....|||||:..|:..|
  Fly  1187 YLSSKKVLHGDLAARNILLCE---DNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSD 1248

  Fly  1381 GIFTSKTDVWSFGILLWEVFSLGRSPYPG-QHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWN 1444
            .:|::.:||||:||:|||:|||.:.|||| ..|.::...:..|.|:..|......:|::|.:||.
  Fly  1249 HVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWR 1313

  Fly  1445 PTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLVPL 1509
            ..||.||.|..|.:...              |:||...:..                   ||   
  Fly  1314 KNPESRPLFAELEKRFA--------------NMLGEDVASH-------------------YL--- 1342

  Fly  1510 PPGGSNNPSMASGSGYVPELQRQQMSSCTPPAVTSPAAP-----HPRP---VENI---------- 1556
               ..|||.|.|...|:.:.....::....|...:||||     |..|   :|.:          
  Fly  1343 ---DLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIRIEELPDDYMEMSRD 1404

  Fly  1557 ----------APT-----SGD----CWETSFILPNSKVEPPV---VGSGHDVPLAGGEEAKLISL 1599
                      :||     |.|    ..||:|..|.::..|.:   :.||...||.  ::..:.::
  Fly  1405 SDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLR--KKNGMPTV 1467

  Fly  1600 DTPQPTPTTIQPPLSFASQ-LDG----------------ITLDPSAL--TKSLPNGNAKQSYANV 1645
            |.....|..| |.|..:|. .||                :|..||..  .::..||...::|.|:
  Fly  1468 DVADQAPEEI-PMLHRSSTGSDGSPEQGRRFNQALKQQYVTPTPSPRHHVETKLNGEPSENYVNM 1531

  Fly  1646 QV--KNEAEAKVINGVVGNGTVMNGDVSTGSGGADSPFTIQGYA 1687
            :.  ||                :.|..:||.|||.:..:.:.::
  Fly  1532 KPPRKN----------------IPGKTTTGGGGAAAGASTEAFS 1559

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_652600.1 MAM 288..447 CDD:99706 43/194 (22%)
MAM 505..689 CDD:99706 55/255 (22%)
PTKc_ALK_LTK 1186..1462 CDD:270632 103/410 (25%)
PvrNP_001162911.1 IG_like 346..432 CDD:214653 26/98 (27%)
Ig strand C 363..366 CDD:409353 0/2 (0%)
Ig strand E 396..400 CDD:409353 0/3 (0%)
Ig strand F 410..415 CDD:409353 1/4 (25%)
Ig strand G 425..428 CDD:409353 0/2 (0%)
Ig 458..533 CDD:472250 20/105 (19%)
Ig strand B 459..463 CDD:409353 1/3 (33%)
Ig strand C 472..476 CDD:409353 1/3 (33%)
Ig strand E 497..503 CDD:409353 3/7 (43%)
Ig strand F 513..518 CDD:409353 0/4 (0%)
Ig 671..>742 CDD:472250 17/122 (14%)
Ig strand B 674..678 CDD:409353 2/4 (50%)
Ig strand C 687..691 CDD:409353 0/3 (0%)
Ig strand E 717..721 CDD:409353 1/3 (33%)
Ig strand F 731..736 CDD:409353 1/4 (25%)
Ig 779..851 CDD:472250 14/100 (14%)
Ig strand B 781..785 CDD:409570 1/3 (33%)
Ig strand C 794..798 CDD:409570 1/3 (33%)
Ig strand E 816..821 CDD:409570 0/4 (0%)
Ig strand F 831..836 CDD:409570 2/7 (29%)
Ig strand G 844..847 CDD:409570 0/2 (0%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 102/421 (24%)

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