DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and Pvr

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster

Alignment Length:	1799	Identity:	367/1799 - (20%)
Similarity:	566/1799 - (31%)	Gaps:	754/1799 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 DPLQEIKDRIRDTSPNANTYAPHTD-------ATPSSEYEYELGVKCNFETPCSWTWGNYSD--G 304
            ||..::.|     |.|..|...:||       |.|.:|...|..   |.|...|.:.|.|..  |
  Fly   155 DPDTKLVD-----SHNVVTARQYTDVVIPCKPAMPDTEVLLETS---NGEMHSSKSVGRYDPQRG 211

  Fly   305 FQVITGTELSKRNLTGLLPGPAADSIDDANGHFLYARVNPSSRPLNLTSPEFSTTMEKCFLE--- 366
            |.:    |:.              ||.|...:  |.|.||.. |.|   .|..|::|..|:.
  Fly   212 FTI----EIR--------------SIVDGGDY--YCRPNPPF-PHN---EEEMTSIEVRFIATGL 252

  Fly   367 ----------VYMHQSDMSHGLSRVVVELLHTAESSWVPAEILGDNVRQWTRKVYRLGRVSRD-- 419
                      ||.:...::.|...|   |..|.:|:...|.|.|.:           |.:||:
  Fly   253 DIPRTQTTNMVYTYAPGVTDGDDEV---LTVTNQSTGNLALIRGGD-----------GTLSRERA 303

  Fly   420 ----FRIV-FEVVPDLRVGQKG--------------HVALDNLRMVNCFPEGTKSEKCSTSQVKC 465
                .|:. ....|..|.||.|              ||..|.
  Fly   304 RRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDT----------------------- 345

  Fly   466 TSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDW-CGWRDSGKTTLTWSR--- 526
                           :.|.||     ||.:..:..||      .:| ...||..:...:.||
  Fly   346 ---------------NFTLDC-----EQSAYVESVYG------MEWFTPSRDENRIFASQSRTDP 384

  Fly   527 HTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLV---NMNQHM------------NNSEKN------ 570
            .|.:| ||.|| ....|:.:.|.:.:|.|..|   |.||::            |.|..|
  Fly   385 KTRNS-THQTG-RSTLTVLNAQPSDTGLYKCVTTDNSNQNVQRATYRIKVLKQNESYLNVGEPSG 447

  Fly   571 --SIIGFASNAIMVSKTFN--PPPSVHG-NPDSPYRNSCVVRFFIHQFGKNPGSINLSVVEMKEK 630
              ::..:|:..|.::..|.  |.||... .||.                          .|:::.
  Fly   448 HYNVQEYANRTIQMTANFEGFPTPSFSWFKPDG--------------------------TEVRQS 486

  Fly   631 EN----ITTTLWWSTKNQ---------------GSD---WMRAEYVLPNIT---------SKYYL 664
            ||    ::|.|  ||..|               ||:   .::.||   |::         |..|:
  Fly   487 ENNFKILSTEL--STMLQVLNAQLQDSGTYVLRGSNSFGVVQREY---NVSVMDAPALKMSDAYV 546

  Fly   665 QF--EARM--GMRIYSDVAVDDF----SLSPE---CFGLNIPEDHLGGYNYWDVRQNLKSPTYKD 718
            |.  .||:  .:|.|....|..|    ||.|:   |..||               ||...|:.::
  Fly   547 QVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLN---------------QNFSLPSEQE 596

  Fly   719 -FEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYKGMQKWKVPHE-GH 781
             :::         .||..  |.:...|..|                 :.|:       :|.| |.
  Fly   597 KYQF---------QTRPR--PGKLSVERIY-----------------EVSF-------LPTEPGI 626

  Fly   782 YTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDH 846
            .|.||:....       |..|.::..|          :.|:|...||..|        .|...||
  Fly   627 LTCIAQNIID-------GKERRTLTKA----------HVLLGNISENMTI--------YGFDKDH 666

  Fly   847 DLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDED 911
            .:        :|:|.| |...|                                  .:..:.|.:
  Fly   667 KI--------AKEDNV-NFTCE----------------------------------ALAYHFDGN 688

  Fly   912 ---FQHGQKAKPLQAPESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYV 973
               |.:|:..|     ||..::.|..:.|.:            ..|..:...:....||.:.|..
  Fly   689 LKWFINGEDLK-----ESDSVHIETSHTKYS------------YKSTVHITTISDRDRGTYECRA 736

  Fly   974 ELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGG--DVYLTE-------SNGEGGSSYISPSR 1029
            ...|....                        |:..  |:|:.:       :.|:.|.|.|  .|
  Fly   737 YHNDKDAV------------------------YSSREIDLYVHDPSAPQWTNGGQEGHSKI--KR 775

  Fly  1030 SLREISEIHAGASSGPGAII----------------------------IIPAIEGCGCDYRCVAL 1066
            .|.:..|:...:::.|.||:                            :.|..||.   |:||.
  Fly   776 KLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGV---YKCVV- 836

  Fly  1067 DEFRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILM-ISLA------VLFICIAALI 1124
                                     |.|.:..:.||..::|.|. ||:|      :||:.:..|.
  Fly   837 -------------------------ENRLDRIERSFTVVISDLPGISMAWVWFGVILFLILIGLC 876

  Fly  1125 FMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLP--- 1186
            ..|..|||::   .|||..|....|.      |.::..:.:.||:...|.      ....||
  Fly   877 VFLAVRYQKE---HKRHLALKAAGLA------NFEEGAVGHINPDLTLDE------QAELLPYNR 926

  Fly  1187 --QVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMA 1249
              :..|::|:|...||.||||.|.....:....:.....||||.::.....|.....:.|..||.
  Fly   927 EFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMV 991

  Fly  1250 KF-NHPNMVHLIGVC---FDRQPYYIVLELLAGGDLQKFLRENRN------TPER----PSLLTM 1300
            .. .|.|:|:|:|..   ..::...:::|....|::|.||..||.      .|:.    ||::|.
  Fly   992 HLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQINPDTDHIDPSIMTQ 1056

  Fly  1301 K---------------------------------------------------------------- 1301
            :
  Fly  1057 RMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTA 1121

  Fly  1302 ---------------------------------------------------DLLFCALDVAKGCR 1315
                                                               ||:..|..||:|..
  Fly  1122 TYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMD 1186

  Fly  1316 YMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLD 1380
            |:.||:.:|.|:||||.||..   ..||||.|||::|.:||.|.|:|.....|||||:..|:..|
  Fly  1187 YLSSKKVLHGDLAARNILLCE---DNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSD 1248

  Fly  1381 GIFTSKTDVWSFGILLWEVFSLGRSPYPG-QHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWN 1444
            .:|::.:||||:||:|||:|||.:.|||| ..|.::...:..|.|:..|......:|::|.:||.
  Fly  1249 HVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWR 1313

  Fly  1445 PTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLVPL 1509
            ..||.||.|..|.:...              |:||...:..                   ||
  Fly  1314 KNPESRPLFAELEKRFA--------------NMLGEDVASH-------------------YL--- 1342

  Fly  1510 PPGGSNNPSMASGSGYVPELQRQQMSSCTPPAVTSPAAP-----HPRP---VENI---------- 1556
               ..|||.|.|...|:.:.....::....|...:||||     |..|   :|.:
  Fly  1343 ---DLNNPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIRIEELPDDYMEMSRD 1404

  Fly  1557 ----------APT-----SGD----CWETSFILPNSKVEPPV---VGSGHDVPLAGGEEAKLISL 1599
                      :||     |.|    ..||:|..|.::..|.:   :.||...||.  ::..:.::
  Fly  1405 SDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLR--KKNGMPTV 1467

  Fly  1600 DTPQPTPTTIQPPLSFASQ-LDG----------------ITLDPSAL--TKSLPNGNAKQSYANV 1645
            |.....|..| |.|..:|. .||                :|..||..  .::..||...::|.|:
  Fly  1468 DVADQAPEEI-PMLHRSSTGSDGSPEQGRRFNQALKQQYVTPTPSPRHHVETKLNGEPSENYVNM 1531

  Fly  1646 QV--KNEAEAKVINGVVGNGTVMNGDVSTGSGGADSPFTIQGYA 1687
            :.  ||                :.|..:||.|||.:..:.:.::
  Fly  1532 KPPRKN----------------IPGKTTTGGGGAAAGASTEAFS 1559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	43/197 (22%)
		MAM	288..447	CDD:99706	43/194 (22%)
		MAM	505..691	CDD:279023	56/257 (22%)
		MAM	505..689	CDD:99706	55/255 (22%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	103/410 (25%)
		TyrKc	1193..1460	CDD:197581	101/396 (26%)
Pvr	NP_001162911.1	IG	346..432	CDD:214652	26/98 (27%)
		Ig	<363..432	CDD:299845	19/70 (27%)
		Ig	466..533	CDD:299845	18/97 (19%)
		IG_like	672..754	CDD:214653	19/157 (12%)
		Ig	674..739	CDD:143165	15/116 (13%)
		IGc2	779..840	CDD:197706	11/89 (12%)
		PKc_like	927..1332	CDD:304357	102/421 (24%)
		Pkinase_Tyr	935..1329	CDD:285015	101/396 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455292
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940