DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and CG3277

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	129/461 - (27%)
Similarity:	212/461 - (45%)	Gaps:	98/461 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1107 SILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYG 1171
            ||:::|..::.|.:|.||.:|..|.:.:..:|.|.:   ||....|...:.|:..:..|:...|.
  Fly   346 SIIVMSAMLIAIILAGLIMLLLRRRRARTTAKLRKQ---EQIYIQTFATSAIEMEDNVNYVDKYV 407

  Fly  1172 CDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMAL---YRHRDGDAVEMGVAVKTLREDP 1233
            ....:.|..|:..:|..|   :|:...||:||||:|:.|.   .|...|..:   ||||.|:.:|
  Fly   408 EKSQVLGLADIFEVPHSA---IQIGRMLGEGAFGQVHEATAINLRRMRGTTI---VAVKQLKPNP 466

  Fly  1234 KREKEEDFLKEAAIMAKF-NHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLR---------EN 1288
            |.::..::|.|..::... .|.|:|..:|.|..:.||.:::|.:..|:|..:||         .|
  Fly   467 KADEVAEYLAEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRN 531

  Fly  1289 RN----------------------------------TPERPS----------------------- 1296
            ||                                  |.|.|.
  Fly   532 RNANYTSCRPIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYT 596

  Fly  1297 ----------LLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMS 1351
                      :|..|:|...||.:|.|.|::|.:...|||:||||.|:.|   .:.:||:|||:|
  Fly   597 IVEDEDAFEYILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDS---NKTLKISDFGLS 658

  Fly  1352 R-DIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQV 1415
            | .||.:...||     ||::|:..||..:.:::||:|:|::|::|||:.:||.||||...|.::
  Fly   659 RHGIYTNTRTRK-----LPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDEL 718

  Fly  1416 MELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGP 1480
            :..::.|.||..|..|...:|.:|..||...||:||||..|.:.|:..|....|.:.....:..|
  Fly   719 IPFLMAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVLSPKTTYVDINSLSDDYVFPP 783

  Fly  1481 TASERD 1486
            .:..|:
  Fly   784 ISENRE 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	106/356 (30%)
		TyrKc	1193..1460	CDD:197581	103/347 (30%)
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	103/347 (30%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	102/343 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455315
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940