DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and Alk

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_001162572.1	Gene:	Alk / 266802	RGDID:	628622	Length:	1617	Species:	Rattus norvegicus

Alignment Length:	1745	Identity:	537/1745 - (30%)
Similarity:	772/1745 - (44%)	Gaps:	361/1745 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 RLHEQPLPLPQPTLPVATQYEDYEAAPPGSRRDNKRRLAQMAQRPGSGNGGRRGMESLRKELMNP 124
            |::.:.|.||||..|                           ..||:|....||..:|.   .:|
  Rat    65 RVYARDLLLPQPPSP---------------------------SEPGAGGLEARGSLALD---CDP 99

  Fly   125 SVG--GPGGGIS-GGGSGYPSYSATSSIGRI--DGLGQGLGSADRYGALYDQLRQPSGMAAMTAG 184
            .:.  ||..||| ..|:..||..|..::.|:  .|..:.|..|       .||....|...:..|
  Rat   100 LLRLLGPSPGISWAEGASSPSPEAAPTLSRVLKGGSVRKLRRA-------KQLVLELGEETILEG 157

  Fly   185 PLGGPYSTRFPPLYAGVDDQPKRSNRKNSISELYKLKKALNQADEPAGGVTHGNFEGD------P 243
            .:|.|            ::.......:.::|||:            :..:.||  ||.      |
  Rat   158 CIGPP------------EEAAAVGILQFNLSELF------------SWWILHG--EGRLRIRLMP 196

  Fly   244 QPSSADPLQE--IKDRIRDTSP----------NANTYAPHTDATPSSEYEYEL------------ 284
            :..:::..:|  :...||.:.|          :::..:|....:|...:.:.|
  Rat   197 EKKASEVGREGRLSTAIRASQPRLLFQIFGTGHSSLESPSEMPSPPGNFLWNLTWTMKDSFPFLS 261

  Fly   285 -----GVKCNFETPCS-------WTWGNYSDGFQVITGTELSKRNLTGLLPGPAADSIDD-ANGH 336
                 |::|:|:.||.       .|.||.|..::.:...|.|:.|   ||.||.|:.:.: ..|.
  Rat   262 HRSRYGLECSFDFPCELEYSPPLHTHGNQSWSWRRVPSEEASRMN---LLDGPEAEHLKEMPRGS 323

  Fly   337 FLYARVNPSSRPLNLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVVELLHTAESSWVPAEIL-- 399
            ||....:..|:. .:.||...::.|.|.|.|.:|:.....|  |.|.:||...|:.   .|||
  Rat   324 FLLLNTSADSKH-TILSPWMRSSSEHCTLAVSVHRHLQPSG--RYVAQLLPHNEAG---REILLV 382

  Fly   400 -GDNVRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTK--SEKCSTS 461
             ......||....|:||....||:..|.:..   |.:...|:|...:.|| .|||.  |:....|
  Rat   383 PTPGKHGWTVLHGRVGRPENPFRVALEYISS---GNRSLSAVDFFALKNC-SEGTSPGSKMALQS 443

  Fly   462 QVKCTSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGWRDS--GKTTLTW 524
            ...|.:..|   :.|.:.||..::|.:.|||.|.|.|:|.|..|:||:.:|||..|  ......|
  Rat   444 SFTCWNGTV---LQLGQACDFHQNCAQGEDEGQLCSKLPAGFYCNFEDGFCGWTQSPLSPRVPRW 505

  Fly   525 SRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNPP 589
            ...|    ..||     |:..|     .|:.:|::......          :.:|.:.|.||  |
  Rat   506 QVKT----LKDT-----HSQGH-----QGHALLLSTTDDPT----------SESATVTSATF--P 544

  Fly   590 PSVHGNPDSPYRNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQG-SDWMRAEY 653
            ..:..:| ...|.|.::|      |...|:::|.:||.|..:..:.|:|....|:| |.|.....
  Rat   545 APMKSSP-CELRMSWLIR------GVLKGNVSLVLVENKTGKEQSRTVWHVATNEGLSLWQWTVL 602

  Fly   654 VLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYNYWDVRQNL--KSPTY 716
            .|.::|.:::||.....|....:.||.|:.|:|.:|: |.|..:.....|.....:||  |:|..
  Rat   603 SLLDVTDRFWLQIVTWWGPGSRATVAFDNISISLDCY-LTISGEEKMSLNAVPKSRNLFEKNPNK 666

  Fly   717 KD------------FEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYK 769
            :.            |:.|.:...|||...|..||:||||..||:..|.:      .||..:...:
  Rat   667 EPKPWANISGPTPIFDPTVHWLFTTCGASGPHGPTQAQCNNAYQNSNLS------VVVGSEGPLR 725

  Fly   770 GMQKWKVPHEGHYTIIAKGASGGLGSGGVGS---SRGSVAVAILELHKNEELYFLVGQQGENACI 831
            |:|.||||....|:|...||:|  |.||..:   |.|...:.|..|.|::.||.|||||||:||.
  Rat   726 GIQIWKVPATDTYSISGYGAAG--GKGGKNTMMRSHGVSVLGIFNLEKDDTLYILVGQQGEDACP 788

  Fly   832 KSMGVLKEAGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVA 896
            ::..::::...|.::.::......||..:..      .|.|||||.:|||.:..  ...|||::|
  Rat   789 RANQLIQKVCVGENNVIEEEIRVNRSVHEWA------GGGGGGGGATYVFKMKD--GVPVPLIIA 845

  Fly   897 GGGGGLGIGQYIDEDFQHGQKAKPLQAPESGQINGEPL----NKKTAGPGGGWRAKEDQALSPTY 957
            .||||..          :|.|.:... ||..:.|...|    |...||.||||   .|.......
  Rat   846 AGGGGRA----------YGAKTETFH-PERLENNSSVLGLNGNSGAAGGGGGW---NDNTSLLWA 896

  Fly   958 GAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVYLT---ESNGE 1019
            |.:||:|..|||||...:...|...    :||||||||||::|||||||.||:....   |.:||
  Rat   897 GKSLLEGAAGGHSCPQAMKKWGWET----RGGFGGGGGGCSSGGGGGGYIGGNAASNNDPEMDGE 957

  Fly  1020 GGSSYISPSRSLREISEIHAGASSGPGAIIIIPAI---EGCG------------CDYRCVALDEF 1069
            .|.|:|||.                  .|:..||:   ||.|            |:.....:|..
  Rat   958 DGVSFISPL------------------GILYTPALKVMEGHGEVNIKHYLNCSHCEVDECHMDPE 1004

  Fly  1070 RSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALI-----FMLYN 1129
            ..||.|.|..| ::..|:..:|.:    ..:...:|...|::|: |....:|||:     .|:.
  Rat  1005 SHKVICFCDHG-TVLADDGVSCIV----SPTPEPHLPLSLILSV-VTSALVAALVLAFSGIMIV- 1062

  Fly  1130 RYQRKKQSKKRHKM-LVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSL 1193
             |:||.|..:..:| |...:.:|::||.:   :.:.::||||...|..:   .::.|.:|.|.::
  Rat  1063 -YRRKHQELQAMQMELQSPEYKLSKLRTS---TIMTDYNPNYCFAGKTS---SISDLKEVPRKNI 1120

  Fly  1194 QLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVH 1258
            .|:..||.|||||||.........|...:.||||||.|....:.|.|||.||.|::||||.|:|.
  Rat  1121 TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVR 1185

  Fly  1259 LIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFI 1323
            .|||.....|.:|:|||:|||||:.||||.|..|.:|:.|.|.|||..|.|:|.||:|:|...||
  Rat  1186 CIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQPTSLAMLDLLHVARDIACGCQYLEENHFI 1250

  Fly  1324 HRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTD 1388
            |||||||||||:..|.||:.||.||||:|||||:.||||||.||||:||||||||::||||||||
  Rat  1251 HRDIAARNCLLTCPGAGRIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTD 1315

  Fly  1389 VWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTF 1453
            .||||:||||:||||..|||.:.|.:|:|.|..|||:..|..||..:|::|..||...|||||.|
  Rat  1316 TWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNF 1380

  Fly  1454 ITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRP--PNG--------------------E 1496
            ..:||.:..||||..::|..||...||...|.:...:||  |.|                    :
  Rat  1381 AIILERIEYCTQDPDVINTALPIEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQSAKHEEASSAPQ 1445

  Fly  1497 EFCLAVPDYLVPLPPGGSNNPSMASGSGYVPE--LQRQQMSSC-----TPPAVTSPAAPHPRPVE 1554
            ...||.|..||..|.|.    ...:|:|.||.  ..|..::..     .||.:........:|..
  Rat  1446 PSALAAPGPLVKKPSGA----GAGAGAGPVPRGAADRGHVNMAFSQPNPPPELHKGPGSRNKPTS 1506

  Fly  1555 NIAPTSGDCWETSFILPNSKVEPP----------VVGSGHDVPLAGGEEAKLISLDTPQPTPTTI 1609
            ...||.|. |.|.  .|..|..||          ....|...|.||...|:.
  Rat  1507 LWNPTYGS-WFTE--KPAKKTHPPPGAEPQARAGAAEGGWTGPGAGPRRAEA------------- 1555

  Fly  1610 QPPLSFASQLDGITLDPSALTKSL-----------PNGNAKQSYANVQVKNEAEA 1653
                       .:.|:||||:.::           |.||....|....:..||.|
  Rat  1556 -----------ALLLEPSALSATMKEVPLFRLRHFPCGNVNYGYQQQGLPLEATA 1599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	49/172 (28%)
		MAM	288..447	CDD:99706	47/169 (28%)
		MAM	505..691	CDD:279023	47/188 (25%)
		MAM	505..689	CDD:99706	46/186 (25%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	155/275 (56%)
		TyrKc	1193..1460	CDD:197581	153/266 (58%)
Alk	NP_001162572.1	MAM	270..431	CDD:279023	47/188 (25%)
		MAM	270..428	CDD:99706	47/185 (25%)
		MAM	484..640	CDD:279023	41/157 (26%)
		MAM	484..635	CDD:99706	41/152 (27%)
		FXa_inhibition	991..1025	CDD:291342	21/36 (58%)
		PTKc_ALK_LTK	1113..1389	CDD:270632	134/281 (48%)
		Pkinase_Tyr	1120..1387	CDD:285015	130/272 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1167
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I786
OMA	1	1.010	-	-		QHG47588
OrthoDB	1	1.010	-	-		D27151at33208
OrthoFinder	1	1.000	-	-		FOG0002954
OrthoInspector	1	1.000	-	-		otm46376
orthoMCL	1	0.900	-	-		OOG6_105014
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4020
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840