Protein Alignment Alk and Tyro3

DIOPT Version :10

• Sequence 1: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Sequence 2: NP_058788.1
• Gene: Tyro3 / 25232
• RGDID: 3923
• Length: 880
• Species: Rattus norvegicus
• Alignment Length: 701
• Identity: 184/701 - (26%)
• Similarity: 283/701 - (40%)
• Gaps: 182/701 - (25%)

  Fly   921 LQAPESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVHRH 985
            ||||.:...|.......::.....|....|       |.|||      |||.|::|        |
  Rat   211 LQAPPAAPFNITVTTISSSNASVAWVPGAD-------GLALL------HSCTVQVA--------H 254

  Fly   986 GQGGFGGGG------------------------GGCNTGGGGGGYAGGDVYLTESNGEGGSSYIS 1026
            ..|.:....                        ..|....|...|  ||....::.|      ::
  Rat   255 APGEWEALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPY--GDWVPFQTKG------LA 311

  Fly  1027 PSRSLREISEIHAGASSGPGAII----IIPAIEGCG----------------------------C 1059
            |:|:.:....|...:    |.|:    :||...|.|                            .
  Rat   312 PARAPQNFHAIRTDS----GLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTTANLT 372

  Fly  1060 DYRCVALDEFRSKVRCICP-----DG-WS--LKRDNHTACEIREEAGK-----SSFQYLVSILMI 1111
            |:     |..:..|..:|.     || ||  |...:|      :.||:     |...::..:|.:
  Rat   373 DW-----DPQKDLVLRVCASNAIGDGPWSQPLVVSSH------DHAGRQGPPHSRTSWVPVVLGV 426

  Fly  1112 SLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFN--------- 1167
            ..|::.....|||.:      ||::.:.|.....  |..:.|....:......:||
  Rat   427 LTALITAAALALILL------RKRRKETRFGQAF--DSVMARGEPAVHFRAARSFNRERPERIEA 483

  Fly  1168 --PNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLR 1230
              .:.|....|...::...:|:   ....|...||||.||.|..|..:..||..|:  ||||.|:
  Rat   484 TLDSLGISDELKEKLEDVLIPE---QQFTLGRMLGKGEFGSVREAQLKQEDGSFVK--VAVKMLK 543

  Fly  1231 EDPKREKE-EDFLKEAAIMAKFNHPNMVHLIGVCF-----DRQPY-YIVLELLAGGDLQKFLREN 1288
            .|.....: |:||:|||.|.:|:||::..|:||..     .|.|. .::|..:..|||..||..:
  Rat   544 ADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLAS 608

  Fly  1289 RNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRD 1353
            | ..|.|..|.::.|:...:|:|.|..|:.|:.|||||:|||||:|:.   ...|.:||||:||.
  Rat   609 R-IGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAE---DMTVCVADFGLSRK 669

  Fly  1354 IYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMEL 1418
            ||..||||:|..:.||:||:..|:..|.::|..:|||:||:.:||:.:.|::||.|..|.::...
  Rat   670 IYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNY 734

  Fly  1419 VVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILG---P 1480
            ::.|.||..|.||...:|.:|..||:..|:.||:|              :.:...|.||||   .
  Rat   735 LISGNRLKQPPECMEEVYDLMYQCWSADPKQRPSF--------------TCLRMELENILGHLSV 785

  Fly  1481 TASERDDTVIR-------PPNGEEFCLAVPDYLVPLPPGGSNNPSMASGSG 1524
            .::.:|...|.       ..||.      |:    ||.|..::.....|||
  Rat   786 LSTSQDPLYINIERAGQPAENGS------PE----LPCGEQSSSEAGDGSG 826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_652600.1	MAM	288..447	CDD:99706
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	108/282 (38%)
Tyro3	NP_058788.1	Ig	40..126	CDD:472250
		Ig strand B	50..54	CDD:409553
		Ig strand C	63..67	CDD:409553
		Ig strand E	90..94	CDD:409553
		Ig strand F	104..109	CDD:409553
		Ig strand G	118..121	CDD:409553
		IgI_2_Axl_Tyro3_like	130..209	CDD:409407
		Ig strand A	130..133	CDD:409407
		Ig strand A'	136..140	CDD:409407
		Ig strand B	144..153	CDD:409407
		Ig strand C	158..165	CDD:409407
		Ig strand C'	167..170	CDD:409407
		Ig strand E	174..185	CDD:409407
		Ig strand F	188..197	CDD:409407
		Ig strand G	201..209	CDD:409407
		FN3	215..307	CDD:238020	19/114 (17%)
		fn3	315..396	CDD:394996	13/89 (15%)
		PTKc_Tyro3	498..781	CDD:270659	111/305 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	804..827		9/33 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	842..864