DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Alk and Insrr

DIOPT Version :9

Sequence 1:NP_001261027.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:XP_006501514.1 Gene:Insrr / 23920 MGIID:1346037 Length:1313 Species:Mus musculus


Alignment Length:450 Identity:147/450 - (32%)
Similarity:222/450 - (49%) Gaps:91/450 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1095 EEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNID 1159
            ||......:..:::..:.. :|.:.:|||.|.    |.||:.|                      
Mouse   913 EEEDTGGMRIFLTVTPVGF-MLLVTLAALGFF----YSRKRNS---------------------- 950

  Fly  1160 DSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGV 1224
             :...:.||.|    ....|:.|....:|.|:.:.::..||:|:||.||..|.|..:.......|
Mouse   951 -TLYTSVNPEY----FSASHMYVPDEWEVPREQIAIIRELGQGSFGMVYEGLARGLEAGEESTPV 1010

  Fly  1225 AVKTLREDPKREKEEDFLKEAAIMAKF--NH-----------PNMVHLIGVCFDRQPYYIVLELL 1276
            |:||:.|.....:..:|||||::|..|  :|           .:.|.|:||....||..:::||:
Mouse  1011 ALKTVNELASARERVEFLKEASVMKAFKCHHVRQEGLPQRSLSSQVRLLGVVSQGQPTLVIMELM 1075

  Fly  1277 AGGDLQKFLR----ENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSK 1337
            ..|||:..||    |..|.|..|. ..:.|::..|.::|.|..|:.:|:|:|||:|||||::|. 
Mouse  1076 TRGDLKSHLRSLRPEAENNPGLPQ-PALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQ- 1138

  Fly  1338 GPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSL 1402
              ...|||.||||:||:|.:||||||||.:||::||.||:..|||||:.:||||||::|||:.:|
Mouse  1139 --DFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTL 1201

  Fly  1403 GRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL------- 1460
            ...||.|..|.||::.|:.||.|.....||:.:.::|..||..:|..||||:.:|:.:       
Mouse  1202 AEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRIQDELRPS 1266

  Fly  1461 ---------TACTQ-DASIMNAPLPNILGPTASERDDTVIRPP--NGEEFCLAVPDYLVP 1508
                     ..|.: .||::         ||.:|.|.    ||  ||      ..||..|
Mouse  1267 FRLCSFYYSPECQRGQASLL---------PTEAEPDS----PPTLNG------ASDYSAP 1307

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_001261027.1 MAM 288..450 CDD:279023
MAM 288..447 CDD:99706
MAM 505..691 CDD:279023
MAM 505..689 CDD:99706
PTKc_ALK_LTK 1186..1462 CDD:270632 117/308 (38%)
TyrKc 1193..1460 CDD:197581 115/283 (41%)
InsrrXP_006501514.1 Recep_L_domain 47..157 CDD:366426
Furin-like 173..329 CDD:366287
Recep_L_domain 346..459 CDD:366426
FN3 494..600 CDD:238020
FN3 605..>649 CDD:238020
FN3 819..908 CDD:238020
PTKc_InsR_like 972..1261 CDD:173625 117/292 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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