Protein Alignment Alk and EPHB1

DIOPT Version :10

• Sequence 1: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Sequence 2: NP_004432.1
• Gene: EPHB1 / 2047
• HGNCID: 3392
• Length: 984
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 143/525 - (27%)
• Similarity: 236/525 - (44%)
• Gaps: 116/525 - (22%)

  Fly  1012 YLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIP----AIEGCGCDYRCVALDEFRSK 1072
            |..:.:.|..||......:...|..:.      ||.:.::.    .:.|.|         :|..|
Human   471 YYEKEHNEFNSSMARSQTNTARIDGLR------PGMVYVVQVRARTVAGYG---------KFSGK 520

  Fly  1073 VRCICPDGWSLKRDNHTACEIREE----AGKSS--FQYLVSILMISLAVLFICIAALIFMLYNRY 1131
            : |.    .:|..|::.: |:||:    ||.::  ..::||::.||:    :|
Human   521 M-CF----QTLTDDDYKS-ELREQLPLIAGSAAAGVVFVVSLVAISI----VC------------ 563

  Fly  1132 QRKKQSKKR--HKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHIDV-------NSLPQ 1187
                 |:||  .|..|..|             .|.:::...|..| :..:||.       .::.:
Human   564 -----SRKRAYSKEAVYSD-------------KLQHYSTGRGSPG-MKIYIDPFTYEDPNEAVRE 609

  Fly  1188 VARD----SLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIM 1248
            .|::    .:::...:|.|.|||||..  |.:.....|:.||:|||:.....::..|||.||:||
Human   610 FAKEIDVSFVKIEEVIGAGEFGEVYKG--RLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIM 672

  Fly  1249 AKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKG 1313
            .:|:|||::.|.||....:|..|:.|.:..|.|..|||:|      ....|:..|:.....:|.|
Human   673 GQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQN------DGQFTVIQLVGMLRGIAAG 731

  Fly  1314 CRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDI--------YRSDYYRKGGKAMLPI 1370
            .:|:....::|||:||||.|::|   ..|.|::|||:||.:        |.|..   |||  :|:
Human   732 MKYLAEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRYLQDDTSDPTYTSSL---GGK--IPV 788

  Fly  1371 KWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSI 1435
            :|..|||.....|||.:||||:||::|||.|.|..||....|..|:..:.:..||..|.:||.::
Human   789 RWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAAL 853

  Fly  1436 YKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCL 1500
            :::|.|||......||.|..::.     |.|..|.|        |.:.:...|:...|:......
Human   854 HQLMLDCWQKDRNSRPRFAEIVN-----TLDKMIRN--------PASLKTVATITAVPSQPLLDR 905

  Fly  1501 AVPDY 1505
            ::||:
Human   906 SIPDF 910

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_652600.1	MAM	288..447	CDD:99706
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	99/287 (34%)
EPHB1	NP_004432.1	EphR_LBD_B1	20..195	CDD:198444
		fn3	326..412	CDD:394996
		fn3	435..518	CDD:394996	9/61 (15%)
		EphA2_TM	542..616	CDD:464211	19/108 (18%)
		PTKc_EphR_B	614..882	CDD:173638	100/288 (35%)
		SAM_EPH-B1	908..975	CDD:188950	2/3 (67%)
		PDZ-binding. /evidence=ECO:0000255	982..984