DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and Ros1

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	XP_011241449.1	Gene:	Ros1 / 19886	MGIID:	97999	Length:	2341	Species:	Mus musculus

Alignment Length:	1681	Identity:	361/1681 - (21%)
Similarity:	583/1681 - (34%)	Gaps:	606/1681 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 VITGTELSKRNLTGLLPGPAADSIDDANGHFLY---------ARVNPSSRPLNLTSPEFSTTMEK 362
            |:||......::..|:...|.||:    |.:||         .|:|..|..:....|..|..
Mouse   770 VLTGHTDIVTHVKLLVNDMAVDSV----GGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGK--- 827

  Fly   363 CFLEVYMHQSDMSHGLSRVVV---ELLH----------------TAESSWVPAEILGDNVRQWTR 408
               :|.....|:|.||...:|   :.:|                |..::|..:||..:.:..::.
Mouse   828 ---KVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGGDATITEFAAWSTSEISQNALMYYSG 889

  Fly   409 KVYRLGRVSRDFRIVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCSTSQVKCTSSKVPVC 473
            :::.:..        |.::....:||:..|::......|.|.....|.|........|...:|
Mouse   890 RLFWING--------FRIITAQEIGQRTSVSVSEPAKFNQFTIIQTSLKPLPGNFSSTPKVIP-- 944

  Fly   474 IHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGWRDSGKTTLTW---------SRHT- 528
                            :..|:|..:|. |....|:..|     :....:.|         |.|:
Mouse   945 ----------------DPVQESSFRIE-GHTSSFQILW-----NEPPAVDWGIVFYSVEFSTHSK 987

  Fly   529 ------GSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMN----QHMNNSEKNSIIGFASNAIMVS 583
                  .|.|.        .|::.|:.     |.|.|::    .:....:|.|:
Mouse   988 FLIIEQQSLPI--------FTVEGLEP-----YTLFNLSVTPYTYWGKGQKTSL----------- 1028

  Fly   584 KTFNPPPSVHGNPDSPYRNSCVVRFFIHQFGKNPGSINLSVVEMK----EKENITTT----LWWS 640
             :|..|.||...|::|       |.||...|:.... |..|||.:    :.||...|    .:..
Mouse  1029 -SFRAPESVPSAPENP-------RIFILSSGRYTKK-NEVVVEFRWNKPKHENGVLTKFEIFYHI 1084

  Fly   641 TKNQGS-----DWMRAEYVLP-------NITSKYYLQFEARM----GMRIYSDVAVDDFSLSPEC 689
            :|..|:     |||.|..:.|       .::.:|.:.|:.|:    |...:||:.:...|....|
Mouse  1085 SKQSGTNRSTEDWMSASVIPPVMSFQLEAVSPEYTVAFQVRVFTSKGPGPFSDIVMSKTSEIKPC 1149

  Fly   690 ------FGLNIPEDHLGGYNYWDVRQNLKSPTYK---DFEYTNYLELTTCDTRGMIGPSQAQCEA 745
                  .|..|.        :.|:.||....|:.   |.....|   ||.|..|...........
Mouse  1150 PYLISLLGNKIV--------FLDMDQNQVLWTFSLEGDVSTVGY---TTDDEMGYFAQGDTLFLL 1203

  Fly   746 AYREQNKTHVLREVHVVED-----------------QSSYKGMQ--------KWKVPHE-----G 780
            ..|..:.:.:.::. :|.|                 ::|..|.|        |.|.|.|     .
Mouse  1204 NLRNHSSSKLFQDA-LVSDIRVIAVDWIARHLYFALKASQNGTQIFNVDLEHKVKSPREVKTCKA 1267

  Fly   781 HYTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNE------ELYF---------------LVGQ 824
            |.|||:                .|:...:..|:..|      ::::               ...|
Mouse  1268 HTTIIS----------------FSIYPLLSRLYWTEVSDLGHQMFYCNISNHTSQHVLQPKASNQ 1316

  Fly   825 QGENACIKSMGVLKEAGCGT--DHDLDLAQYSFRSKQDM----------VKNIYIENGAGGGG-- 875
            .|.:.|..::...:.:|..|  ..|.|.....|..:|::          .|.|.:.....|..
Mouse  1317 HGRSQCSCNVTESELSGAMTVDTSDPDRPWIYFTKRQEIWAMDLEGCQCWKVIMVPTIPAGKRII 1381

  Fly   876 ----GGSYVFLLNQAKNEAVPLLVAGGGGGL-----------------GIGQYIDEDF------- 912
                .|.:::.:.:.|::|.......|.|.:                 .:..:.|:.:
Mouse  1382 SLTVDGEFIYWIMKTKDDAQIYQAKKGSGAILSQVKASRSKHILAYSSALQPFPDKAYLSLASDM 1446

  Fly   913 -------------------------QHG----------------------QKAKPLQAPES-GQI 929
                                     .||                      ::.|.|::.|: .:|
Mouse  1447 VEATILYATNTSLTLKLPPVKTNLTWHGITHPTSTYLIYYMEANRANSSDRRHKMLESQENVARI 1511

  Fly   930 NG------------------EPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVE-- 974
            .|                  |||.....|       ||.|..:        :.|..|..|::.
Mouse  1512 EGLQPFSMYMIQIAVKNYYSEPLEHLPLG-------KEIQGQT--------KSGVPGAVCHINAT 1561

  Fly   975 -LADNGTSVH----------------RH---------------GQGGFGG----------GGG-- 995
             |:|  ||:|                |:               .||.|..          .||
Mouse  1562 VLSD--TSLHVFWTESHKPNGPKESVRYQLVMSYLAPIPETPLRQGEFPSAKLSLLITKLSGGQL 1624

  Fly   996 ------GCNTGGGGGGYAGGDVYLTESN---------GEGGSSYISPSRSLR------------- 1032
                  .|:.         .:::.|||:         .|..|:.:..:.||:
Mouse  1625 YVMKVLACHP---------EEMWCTESHPVSVNMFDTPEKPSALVPENTSLQLDWKARSNVNLTG 1680

  Fly  1033 -----------EISEIHAGASSGPGAIIIIPAIEG-CGCDYRCVAL-----------DEFRSKVR 1074
                       |...:.|..|.||..:..|..::. ...:.|.|.:           :.|::|..
Mouse  1681 FWFELQKWKYNEFYHVKASCSQGPVYVCNITDLQPYTSYNIRVVVVYTTGENSSSIPESFKTKAG 1745

  Fly  1075 CICPDG-------------WSLKRDN----------------------------------HTACE 1092
            .....|             |....||                                  .:.|.
Mouse  1746 VPSKPGIPKLLEGSKNSIQWEKAEDNGSRLMYYTLEVRKGISNDSQNQSSRWKVVFNGSCSSICT 1810

  Fly  1093 IREEAGKSSFQY---------------------LVS----------ILMISLAVLFICIAALIFM 1126
            .|.:..|.:||:                     ||.          ||.|.:.:..:....|.|:
Mouse  1811 WRSKNLKGTFQFRAVAANEIGLGEYSEISEDITLVEDGVWITETSFILTIIVGIFLVATVPLTFV 1875

  Fly  1127 LYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGCDGILNGHI-----DVNSLP 1186
            .:...:..|.||:...:|.:.|.:|..||.......|.|     .|..:   |.     ::.:||
Mouse  1876 WHRSLKSHKASKEGLSVLNDNDKELAELRGLAAGVGLAN-----ACYAV---HTVPTQEEIENLP 1932

  Fly  1187 QVARDSLQLVNALGKGAFGEVYMALYRHRDGDAV--------EMGVAVKTLREDPKREKEEDFLK 1243
            ...|:.|.|...||.|||||||       :|.|:        |:.||||||::....:::.:|||
Mouse  1933 AFPREKLSLRLLLGSGAFGEVY-------EGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLK 1990

  Fly  1244 EAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCAL 1308
            ||.:|:||||||::..:|||...:|.||:|||:.||||..:||:.|.|......||:.||:...:
Mouse  1991 EAHLMSKFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGPSLTLLDLVELCV 2055

  Fly  1309 DVAKGCRYMESKRFIHRDIAARNCLLSSK---GPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPI 1370
            |::|||.|:|...|||||:||||||:|.|   .| |||||.|||::|:||::|||||.|:.:||:
Mouse  2056 DISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSP-RVVKIGDFGLAREIYKNDYYRKRGEGLLPV 2119

  Fly  1371 KWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSI 1435
            :||.||..:||||||::||||||||:||:.:||..|||...|..|:..|..||||..|..||..:
Mouse  2120 RWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDL 2184

  Fly  1436 YKVMADCWNPTPEDRPTFITL-----------LEHLTACTQDASIMNAPLPNILGPTASERDDTV 1489
            :.:|:.||...|:.||||..:           |.:::.|.:     .||...::.......||.:
Mouse  2185 WNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNVSHCGE-----AAPTGGVINKGFEGEDDEM 2244

  Fly  1490 IRPPNGEEFCLAVPD--------YLVPLPPGGSNNPSMASGSGYVPELQRQQMSSC 1537
            :...:.:...:|:.:        |:|.     :...|...|| |...|..:::.||
Mouse  2245 VTLNSDDTMPVALMETKNQEGLNYMVL-----ATKCSQGEGS-YEGPLGPKELGSC 2294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	31/170 (18%)
		MAM	288..447	CDD:99706	30/167 (18%)
		MAM	505..691	CDD:279023	46/235 (20%)
		MAM	505..689	CDD:99706	45/227 (20%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	138/297 (46%)
		TyrKc	1193..1460	CDD:197581	136/288 (47%)
Ros1	XP_011241449.1	FN3	112..179	CDD:214495
		FN3	207..291	CDD:238020
		FN3	568..664	CDD:238020
		FN3	1037..1143	CDD:238020	26/113 (23%)
		FN3	1552..1631	CDD:238020	13/80 (16%)
		FN3	1651..1742	CDD:238020	13/90 (14%)
		FN3	1747..1840	CDD:238020	9/92 (10%)
		PTKc_c-ros	1949..2210	CDD:270640	130/268 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27151at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820