DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and rol-3

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_001256097.1	Gene:	rol-3 / 179204	WormBaseID:	WBGene00004395	Length:	2481	Species:	Caenorhabditis elegans

Alignment Length:	1356	Identity:	291/1356 - (21%)
Similarity:	474/1356 - (34%)	Gaps:	440/1356 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   422 IVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCSTSQVKCTSSKVPVC---IHLPRICDIT 483
            |||.:|.:.:.|.              |.|.|||...|:    |....:|..   |:..|
Worm  1443 IVFSIVNEGKTGS--------------FLEVTKSSSSSS----CQEVSMPQTQYEIYFTR----- 1484

  Fly   484 RDCDEAEDEQQSCDKIPY-GGRCDFEEDWCGWRDSGKTTLTWSRHTGSSPTHDTGPDGDHTMQHL 547
            ::.|:.:..:...|:|.. .|..|.|.|:       ..|:||
Worm  1485 KNTDKVKHVRSFSDRIHVENGILDKETDY-------DVTVTW----------------------- 1519

  Fly   548 QNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNPPPSVHGNPDSPYRNSCVVRFFIHQ 612
                        :|::.           .::.:..||:|.   :..|.|.:|
Worm  1520 ------------LNRYS-----------PASGVSASKSFR---TGFGYPSAP------------- 1545

  Fly   613 FGKNPGSINLSVVEMKEKENITTTLWWS---TKNQGSDWMRAEYVLPNITSKYYLQFEARMGMRI 674
              ::|.:|.::        ..|..|:|:   |.|           .|....||.:..:| .|:.:
Worm  1546 --RDPHAIPVT--------PDTVYLYWNLPETLN-----------APISEIKYKISQQA-AGISV 1588

  Fly   675 YSDVAVDDFSLSPECFGLNIPEDHLGGYNYWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPS 739
            .:.:||  .:||.                  .|..|:.|.|            |:|    :|.|.
Worm  1589 PTSIAV--IALSE------------------TVSSNISSDT------------TSC----LINPC 1617

  Fly   740 QAQCEAAYREQNK-------THV--LREVHVVEDQ---SSYKGMQKWKVPHEGHYTIIAKGASGG 792
            :.:. |..|..|:       ||:  |....:::|.   ||....:...||             |.
Worm  1618 RVKI-ANLRPSNEYKFWVTATHISHLDAATILKDDDAVSSEAVARTLDVP-------------GT 1668

  Fly   793 LGSGGV-GSSRGSVAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFR 856
            |....| |||.                                 :|:..|...:|
Worm  1669 LRPDNVTGSSL---------------------------------LLRWNGLEPEH---------- 1690

  Fly   857 SKQDMVKNIYIENGAGGGGGGSYVFLLN-----QAKNEAVPL------------LVAGGGGGLGI 904
                ...:|.::....||....:.|.:|     ....|.||:            .||...|...|
Worm  1691 ----RPSSIAVQYRESGGANNEWQFPMNVSFEPDVTTELVPITNLLSATSYDYRFVATYTGTYTI 1751

  Fly   905 -GQYI--DEDFQHGQKAKPLQAPESGQIN-GEPLNKKTAGPGGGWRAKED-QALSPTYGAALLQG 964
             |:.:  .||:        ||.|:..:.. |.|...:..      .||:| :....|:...:..|
Worm  1752 DGKVLAFKEDY--------LQLPQQARTKAGVPTAPQFV------EAKQDEEGWIVTWKEPMSDG 1802

  Fly   965 GRGGHSCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVYLTESNGEGGSSYISPSR 1029
            |....|..||...|.|:.....:.|..|.......|...          |.|         |.|.
Worm  1803 GSPITSYAVETRINKTAEWEIAERGLDGWKTWWRPGKSD----------TTS---------STST 1848

  Fly  1030 SLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFRSKVRCICPDGWSLKRDNHTACEIR 1094
            |..|:||....|::          |||.|                     .::...|..   |.:
Worm  1849 SSTEVSEFRIRAAN----------IEGFG---------------------AYAYTEDKK---EEK 1879

  Fly  1095 EEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNID 1159
            ||...|...||:.:.:|.|....|.:|.  |.|.:|  |::|.|||........::|..:.|...
Worm  1880 EEEPSSVLPYLLLLSIIFLLAAMILVAC--FWLKSR--RRQQQKKREAEDERNCIRLDVVANMNF 1940

  Fly  1160 DSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVE--- 1221
            .|:..:..|.|        ..::.:||.|...::...:.:...|:|.|:       .|.|.|
Worm  1941 SSSHQSLPPEY--------ESEMRNLPVVNYSTVTFNDYIDTCAYGIVH-------SGTAEEVPM 1990

  Fly  1222 -----MGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDL 1281
                 :.||:|.|:.:...:::..|:|||.::...:|||:|..:|||.......|:||.:.||:|
Worm  1991 SWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLNNLDHPNIVKELGVCITPGQELILLEYMEGGNL 2055

  Fly  1282 QKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIA 1346
            .|||:::.....:.|.|:.:|||..::|:|:|..|:|....:|::::||.|||:.: || |.|:
Worm  2056 LKFLQKSTPNEYQSSELSPRDLLSISVDIARGMNYLERLPHVHKNLSARKCLLAGR-PG-VTKL- 2117

  Fly  1347 DFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQH 1411
            :.|||:::......|...:.|..::||.||...|..|:||:|||::|:||:||||.|..||..:.
Worm  2118 EMGMSKELSNGQVNRSDLENMEIVRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGDKD 2182

  Fly  1412 NTQVMELVVRGGRLGSPTECPVS-IYKVMADCWNPTPEDRPTFITLLEHLT-------------- 1461
            |.::|..|..|..|..|:.||.. ||||:..|.......|..|.|:|:...
Worm  2183 NRRIMTDVRNGSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIFETFRDDQKCQDDKPI 2247

  Fly  1462 -----------ACTQDASIMNAPLPNILGPTASER-----DDTVIRPPNGEEFCLAVPDYL---- 1506
                       :.:||::....|      |:.|.|     |...:.||:        |.:|
Worm  2248 QFNDGTDNTNFSASQDSTSSREP------PSPSHRMRDFIDTRDLEPPS--------PSHLNQSF 2298

  Fly  1507 --VPLPPGGSNNPSMASGSGYVPELQRQQMSSCTPPAVTSP-------AAPHPRPVENIAPTSGD 1562
              ...|..|....:|.:|||.....:.....|.....:.:|       .|.:.||   ::..|.|
Worm  2299 GGFEHPYEGERPATMWNGSGARNSAKNSIGRSMKKEKLRNPIHSMDDLVARNQRP---LSIHSED 2360

  Fly  1563 CWETSFILPNSKVEPPVVGSGHDVPLAGGEEAKLISLDTPQPTPTTIQPPLSFASQLDGITLDPS 1627
            ...|.:...:|...|   ||.:.:                   .:.:.||:...|...||.:...
Worm  2361 TESTDYGASSSMYSP---GSSNRI-------------------SSQVDPPIGRLSSAPGIGIVND 2403

  Fly  1628 ALTKSLPNGNAKQSYANV--QVKNEAEAKVINGVVGNGTVMNG-----DVSTGSGG 1676
            |...|.|:.|..:|:|.:  :|.........:|.:...|...|     .|..|:||
Worm  2404 AFESSNPSLNLSRSWAGLSREVNQNPAGAGSSGTLPQHTNSAGHLRLPGVQVGAGG 2459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	5/27 (19%)
		MAM	288..447	CDD:99706	5/24 (21%)
		MAM	505..691	CDD:279023	29/188 (15%)
		MAM	505..689	CDD:99706	29/186 (16%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	95/309 (31%)
		TyrKc	1193..1460	CDD:197581	93/275 (34%)
rol-3	NP_001256097.1	FN3	1542..1636	CDD:238020	29/165 (18%)
		fn3	1664..1749	CDD:278470	22/144 (15%)
		STYKc	1966..2232	CDD:214568	93/275 (34%)
		PTKc	1970..2233	CDD:270623	93/272 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27151at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820