Protein Alignment Alk and scd-2

DIOPT Version :10

• Sequence 1: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Sequence 2: NP_504685.3
• Gene: scd-2 / 179054
• WormBaseID: WBGene00004740
• Length: 1421
• Species: Caenorhabditis elegans
• Alignment Length: 1424
• Identity: 382/1424 - (26%)
• Similarity: 566/1424 - (39%)
• Gaps: 338/1424 - (23%)

  Fly   190 YSTRFPPLYAGVDDQPKRSNRKNSISELYKLKKALNQADEPAGGVTHGNFEGDPQPSSADPLQEI 254
            |:.||.     ::|:...|:|...||...|.|.|...|...            |..|....:||
 Worm    33 YADRFL-----IEDEENGSSRSYYISAESKAKAAEQFALLA------------PNCSLTSDIQE- 79

  Fly   255 KDRIRDTSPNANTYAPHTDATPSSEYEYELGVKCN--FET------------------------- 292
                 :|....:::..|...:....|.|| ..|||  .||
 Worm    80 -----NTCNETSSFCDHRVDSTYKTYHYE-QEKCNCFIETCDEETNSTELMVLYPDCYCGKREKH 138

  Fly   293 ------PCSWTWGNYSDG--FQVITGTELSKRNLTGLLPGPAADSIDDANGHFLYARVNPSSRPL 349
                  .|.||..:..|.  |:|.   |.|.:.|...:....::            :.|.....:
 Worm   139 CDLSKEKCHWTPDSDHDDLKFEVF---ESSNKVLFDYMLQAGSE------------KANLKMNKV 188

  Fly   350 NLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVV-ELLHTAESS-----WV-PAEILGDNVRQWT 407
            ::.|..|..:...|.|. :||........||:|| .:|.:.|..     |: ||.:.      |.
 Worm   189 SMVSKFFRQSGFNCSLR-FMHHFTHQSSTSRLVVRSILQSGEKKNLYEHWLKPASVF------WV 246

  Fly   408 RKVYRLGRVSRDFRIVFE----VVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCST-SQVKCTS 467
            .....:|..:..|:|..:    ..|..:..:....::.::...||.......|:||. .|..|:.
 Worm   247 PVQVAIGSYAEPFKISIDCETGFPPKKKKNKPFTCSIADIYFENCGEIRDPIEQCSRGDQFLCSI 311

  Fly   468 SKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFE-EDWCGWRDSGKTTLTWSRHTGSS 531
            |....|:...: ||...|||:..|| ..|..| .|..|||. :|:|.         :|.:.|..:
 Worm   312 SANTRCLQNAQ-CDSRIDCDDESDE-MDCGNI-NGTMCDFNGQDYCN---------SWYQVTNVT 364

  Fly   532 PTHD--TGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNP------ 588
            ..|:  :.|.....:..|.......:.|.:.:..:..:.:.|     .|.::.....||
 Worm   365 DYHERLSEPTTVAPLNKLNEVPLHLFRLQSPSAKIKEAMRGS-----GNMLVFDHKPNPLTRRTS 424

  Fly   589 ----PPSVHGNPD-----SPYRNSCVVRFF-------------IHQFGKNPGSINLSVV-----E 626
                |.....||:     ||...||.:||:             :...|.||.....:::     .
 Worm   425 ALVSPELPRTNPEAYDEKSPLFKSCKLRFYLCSRTYSKVWQISVISKGINPMESGRTIIYEAGYT 489

  Fly   627 MKEKENITTTLWWSTKNQGSDWMRAEYVLPNITSKYYLQFEARMGMRIYS-------DVAVDDFS 684
            :..|||.|             |.|....:|...:.:      |:|:.:.:       .||:|:.|
 Worm   490 LIPKENCT-------------WERVFVNIPRQNAGF------RIGIFVTNYFPGSEEYVAIDNLS 535

  Fly   685 LSPECFGLNIPEDHLGGYNYWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYRE 749
            .||.||..:|.:      :.||:..               |.:.||...|...|.  .|:.....
 Worm   536 FSPTCFERDINQ------STWDIPD---------------LFINTCGASGFEQPQ--NCDHNREL 577

  Fly   750 QNKT-HVLREVHVVEDQSSYKGMQKWKVPHEGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELH 813
            ..:| |.|:|          .|.|:|.||..|.|.:...||.||..|...|.:...|.:.: .|.
 Worm   578 DGQTGHFLKE----------DGTQQWTVPVTGFYRMEICGAGGGSNSKASGDTGDCVTLQV-HLI 631

  Fly   814 KNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGS 878
            :|..|..|:||.||:.|.            |:||.:|..    |....:.:.|:.:|..|..||.
 Worm   632 ENLSLRMLIGQMGESPCF------------TEHDDELRP----SSCSKISHNYVYDGKRGAAGGG 680

  Fly   879 YVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAKPLQAPESGQINGEPLNKKTAGPGG 943
             ..||...|:  :..:|||||.|.....:   |.:.|..|..:
 Worm   681 -ATLLTVEKD--LWNVVAGGGAGASWDGF---DMEVGYGASAI---------------------- 717

  Fly   944 GWRAKEDQALSPTYGAALLQGGRGGHSCY-VELADN---GTSVHRHGQGGFGGGGGGCN-TGGGG 1003
              ..|.||..:.|..|.       .|:.: ||..||   |........|||||||..|. .||.|
 Worm   718 --HVKPDQRCNETCKAV-------SHTDFIVERRDNRCPGEKGESTVFGGFGGGGNSCGMLGGSG 773

  Fly  1004 GGYAGGDVYLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDE 1068
            .||..|:.: .:|....|||.:|...|...|  .:.......|.|.|....:.|.....|....:
 Worm   774 AGYQAGNPF-GKSRARSGSSNVSIDFSKSPI--YYQSERLDEGYIKIAFCRKRCEPPTVCRFRKD 835

  Fly  1069 FRSKVRCICPDGWSLKRDNHTACEIREEAGKSS------FQY----------------------- 1104
            :..:..|.|||| |...|...||........||      |.|
 Worm   836 YFEEEYCGCPDG-SNVTDTEEACAFPLVCPSSSTNQYRNFTYEPFCLCNNGKEIYDVYNDTCEEI 899

  Fly  1105 ----LVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNN 1165
                |.:|..:..|.|.| |.|| |::|:...|:||.|       ::.|.||:::
 Worm   900 QIWTLYNITFLIFAALTI-IGAL-FVVYHYRNREKQMK-------QEILDLTQMK---------- 945

  Fly  1166 FNPNYGCDGILNGHID----VNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAV 1226
             :|:|..|.|..|...    ::|||.::|||::....||:|.|||||...|     ..|::.|.:
 Worm   946 -SPDYLYDDIYFGRTTRKAALDSLPSISRDSIERGRVLGRGNFGEVYYGEY-----SGVKLAVKM 1004

  Fly  1227 KTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNT 1291
            .:......:..:.||..||..|..|...|:|.|||:.|::.||.|.||.:.||||..|::|.|
 Worm  1005 ISRTFSASQASQSDFCNEALCMGTFVDENVVRLIGIDFEKVPYMIALEYMEGGDLLSFVKECR-- 1067

  Fly  1292 PERPSL----LTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSR 1352
            |.:.||    |.|.||:....|||.||:.:|:..::||||||||.||:::||.||.|||||||::
 Worm  1068 PNQVSLNPFQLAMSDLIKICCDVAAGCKCLETFGYVHRDIAARNILLTTRGPQRVAKIADFGMAK 1132

  Fly  1353 DI-YRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVM 1416
            :| |.::|||..|:.|:||||.|||||:||:||:|:|:||||:|.|||||||..|||.:.|.:||
 Worm  1133 EITYGTEYYRINGRTMMPIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRRNEEVM 1197

  Fly  1417 ELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLP 1475
            .::..|.||..|...|..:|::|.|||.....|||.|:.::|.......|.:.:..|.|
 Worm  1198 LMLTEGARLEYPYGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQDIQDDPASVGMPFP 1256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_652600.1	MAM	288..447	CDD:99706	34/204 (17%)
		MAM	505..689	CDD:99706	42/226 (19%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	128/280 (46%)
scd-2	NP_504685.3	LDLa	305..338	CDD:238060	11/34 (32%)
		Gly_rich	599..804	CDD:403882	72/261 (28%)
		Protein Kinases, catalytic domain	969..1239	CDD:473864	127/276 (46%)