DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and scd-2

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_504685.3	Gene:	scd-2 / 179054	WormBaseID:	WBGene00004740	Length:	1421	Species:	Caenorhabditis elegans

Alignment Length:	1424	Identity:	382/1424 - (26%)
Similarity:	566/1424 - (39%)	Gaps:	338/1424 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 YSTRFPPLYAGVDDQPKRSNRKNSISELYKLKKALNQADEPAGGVTHGNFEGDPQPSSADPLQEI 254
            |:.||.     ::|:...|:|...||...|.|.|...|...            |..|....:||
Worm    33 YADRFL-----IEDEENGSSRSYYISAESKAKAAEQFALLA------------PNCSLTSDIQE- 79

  Fly   255 KDRIRDTSPNANTYAPHTDATPSSEYEYELGVKCN--FET------------------------- 292
                 :|....:::..|...:....|.|| ..|||  .||
Worm    80 -----NTCNETSSFCDHRVDSTYKTYHYE-QEKCNCFIETCDEETNSTELMVLYPDCYCGKREKH 138

  Fly   293 ------PCSWTWGNYSDG--FQVITGTELSKRNLTGLLPGPAADSIDDANGHFLYARVNPSSRPL 349
                  .|.||..:..|.  |:|.   |.|.:.|...:....::            :.|.....:
Worm   139 CDLSKEKCHWTPDSDHDDLKFEVF---ESSNKVLFDYMLQAGSE------------KANLKMNKV 188

  Fly   350 NLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVV-ELLHTAESS-----WV-PAEILGDNVRQWT 407
            ::.|..|..:...|.|. :||........||:|| .:|.:.|..     |: ||.:.      |.
Worm   189 SMVSKFFRQSGFNCSLR-FMHHFTHQSSTSRLVVRSILQSGEKKNLYEHWLKPASVF------WV 246

  Fly   408 RKVYRLGRVSRDFRIVFE----VVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCST-SQVKCTS 467
            .....:|..:..|:|..:    ..|..:..:....::.::...||.......|:||. .|..|:.
Worm   247 PVQVAIGSYAEPFKISIDCETGFPPKKKKNKPFTCSIADIYFENCGEIRDPIEQCSRGDQFLCSI 311

  Fly   468 SKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFE-EDWCGWRDSGKTTLTWSRHTGSS 531
            |....|:...: ||...|||:..|| ..|..| .|..|||. :|:|.         :|.:.|..:
Worm   312 SANTRCLQNAQ-CDSRIDCDDESDE-MDCGNI-NGTMCDFNGQDYCN---------SWYQVTNVT 364

  Fly   532 PTHD--TGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNP------ 588
            ..|:  :.|.....:..|.......:.|.:.:..:..:.:.|     .|.::.....||
Worm   365 DYHERLSEPTTVAPLNKLNEVPLHLFRLQSPSAKIKEAMRGS-----GNMLVFDHKPNPLTRRTS 424

  Fly   589 ----PPSVHGNPD-----SPYRNSCVVRFF-------------IHQFGKNPGSINLSVV-----E 626
                |.....||:     ||...||.:||:             :...|.||.....:::     .
Worm   425 ALVSPELPRTNPEAYDEKSPLFKSCKLRFYLCSRTYSKVWQISVISKGINPMESGRTIIYEAGYT 489

  Fly   627 MKEKENITTTLWWSTKNQGSDWMRAEYVLPNITSKYYLQFEARMGMRIYS-------DVAVDDFS 684
            :..|||.|             |.|....:|...:.:      |:|:.:.:       .||:|:.|
Worm   490 LIPKENCT-------------WERVFVNIPRQNAGF------RIGIFVTNYFPGSEEYVAIDNLS 535

  Fly   685 LSPECFGLNIPEDHLGGYNYWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYRE 749
            .||.||..:|.:      :.||:..               |.:.||...|...|.  .|:.....
Worm   536 FSPTCFERDINQ------STWDIPD---------------LFINTCGASGFEQPQ--NCDHNREL 577

  Fly   750 QNKT-HVLREVHVVEDQSSYKGMQKWKVPHEGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELH 813
            ..:| |.|:|          .|.|:|.||..|.|.:...||.||..|...|.:...|.:.: .|.
Worm   578 DGQTGHFLKE----------DGTQQWTVPVTGFYRMEICGAGGGSNSKASGDTGDCVTLQV-HLI 631

  Fly   814 KNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGGS 878
            :|..|..|:||.||:.|.            |:||.:|..    |....:.:.|:.:|..|..||.
Worm   632 ENLSLRMLIGQMGESPCF------------TEHDDELRP----SSCSKISHNYVYDGKRGAAGGG 680

  Fly   879 YVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAKPLQAPESGQINGEPLNKKTAGPGG 943
             ..||...|:  :..:|||||.|.....:   |.:.|..|..:
Worm   681 -ATLLTVEKD--LWNVVAGGGAGASWDGF---DMEVGYGASAI---------------------- 717

  Fly   944 GWRAKEDQALSPTYGAALLQGGRGGHSCY-VELADN---GTSVHRHGQGGFGGGGGGCN-TGGGG 1003
              ..|.||..:.|..|.       .|:.: ||..||   |........|||||||..|. .||.|
Worm   718 --HVKPDQRCNETCKAV-------SHTDFIVERRDNRCPGEKGESTVFGGFGGGGNSCGMLGGSG 773

  Fly  1004 GGYAGGDVYLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDE 1068
            .||..|:.: .:|....|||.:|...|...|  .:.......|.|.|....:.|.....|....:
Worm   774 AGYQAGNPF-GKSRARSGSSNVSIDFSKSPI--YYQSERLDEGYIKIAFCRKRCEPPTVCRFRKD 835

  Fly  1069 FRSKVRCICPDGWSLKRDNHTACEIREEAGKSS------FQY----------------------- 1104
            :..:..|.|||| |...|...||........||      |.|
Worm   836 YFEEEYCGCPDG-SNVTDTEEACAFPLVCPSSSTNQYRNFTYEPFCLCNNGKEIYDVYNDTCEEI 899

  Fly  1105 ----LVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNN 1165
                |.:|..:..|.|.| |.|| |::|:...|:||.|       ::.|.||:::
Worm   900 QIWTLYNITFLIFAALTI-IGAL-FVVYHYRNREKQMK-------QEILDLTQMK---------- 945

  Fly  1166 FNPNYGCDGILNGHID----VNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAV 1226
             :|:|..|.|..|...    ::|||.::|||::....||:|.|||||...|     ..|::.|.:
Worm   946 -SPDYLYDDIYFGRTTRKAALDSLPSISRDSIERGRVLGRGNFGEVYYGEY-----SGVKLAVKM 1004

  Fly  1227 KTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNT 1291
            .:......:..:.||..||..|..|...|:|.|||:.|::.||.|.||.:.||||..|::|.|
Worm  1005 ISRTFSASQASQSDFCNEALCMGTFVDENVVRLIGIDFEKVPYMIALEYMEGGDLLSFVKECR-- 1067

  Fly  1292 PERPSL----LTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSR 1352
            |.:.||    |.|.||:....|||.||:.:|:..::||||||||.||:::||.||.|||||||::
Worm  1068 PNQVSLNPFQLAMSDLIKICCDVAAGCKCLETFGYVHRDIAARNILLTTRGPQRVAKIADFGMAK 1132

  Fly  1353 DI-YRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVM 1416
            :| |.::|||..|:.|:||||.|||||:||:||:|:|:||||:|.|||||||..|||.:.|.:||
Worm  1133 EITYGTEYYRINGRTMMPIKWTPPEAFIDGVFTTKSDIWSFGVLCWEVFSLGVVPYPNRRNEEVM 1197

  Fly  1417 ELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLP 1475
            .::..|.||..|...|..:|::|.|||.....|||.|:.::|.......|.:.:..|.|
Worm  1198 LMLTEGARLEYPYGIPTRVYQLMRDCWKTAAADRPKFVDVVEIFQDIQDDPASVGMPFP 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	36/207 (17%)
		MAM	288..447	CDD:99706	34/204 (17%)
		MAM	505..691	CDD:279023	43/228 (19%)
		MAM	505..689	CDD:99706	42/226 (19%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	128/280 (46%)
		TyrKc	1193..1460	CDD:197581	124/271 (46%)
scd-2	NP_504685.3	LDLa	305..338	CDD:238060	11/34 (32%)
		Gly_rich	590..805	CDD:289573	76/271 (28%)
		PKc_like	969..1239	CDD:304357	127/276 (46%)
		TyrKc	976..1241	CDD:197581	124/271 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158302
Domainoid	1	1.000	248	1.000	Domainoid score	I1177
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I1356
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002954
OrthoInspector	1	1.000	-	-		oto17813
orthoMCL	1	0.900	-	-		OOG6_105014
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3599
SonicParanoid	1	1.000	-	-		X4020
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780