DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and Met

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_032617.2	Gene:	Met / 17295	MGIID:	96969	Length:	1379	Species:	Mus musculus

Alignment Length:	1424	Identity:	299/1424 - (20%)
Similarity:	490/1424 - (34%)	Gaps:	512/1424 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 KRSNRK---NSISELYKLKKALNQADE----PAGGVTHGNFEGDPQPSSADPLQEIKDRIRDTSP 263
            |||.|:   |.:...|..|...|.|.:    |:..:..|.| ...:|.||:|:
Mouse   305 KRSTREEVFNILQAAYVSKPGANLAKQIGASPSDDILFGVF-AQSKPDSAEPV------------ 356

  Fly   264 NANTYAPHTDATPSSEYEYELGVKCNFETPCSWTWGNYSDGFQVITGTELSKRNLTGLLPGPAAD 328
                                     |....|::.....:|.|..|    ::|.|:..|
Mouse   357 -------------------------NRSAVCAFPIKYVNDFFNKI----VNKNNVRCL------- 385

  Fly   329 SIDDANGHFLYARVNPSSRPLNLTSPEFSTTMEKCFLEVYM------------HQSDMSHGLSRV 381
                  .||                  :....|.||....:            ::::.:..|.||
Mouse   386 ------QHF------------------YGPNHEHCFNRTLLRNSSGCEARSDEYRTEFTTALQRV 426

  Fly   382 ------VVELLHTAESSWVPAEI----LGDNVRQWTRKVY-RLGRVSRDFRIVFE---VVPDLRV 432
                  :.::|.|:.|:::..::    ||.:..::.:.|. |...::.....:.:   |.|::.|
Mouse   427 DLFMGRLNQVLLTSISTFIKGDLTIANLGTSEGRFMQVVLSRTAHLTPHVNFLLDSHPVSPEVIV 491

  Fly   433 ----GQKGHVALDNLRMVNCFPEGTKSEKCSTSQVKCTSSKVPV----CIHLPRICDITRDCDEA 489
                .|.|:..:...:.:                     :|:|:    |.|.       :.|.:
Mouse   492 EHPSNQNGYTLVVTGKKI---------------------TKIPLNGLGCGHF-------QSCSQ- 527

  Fly   490 EDEQQSCDKIPYGGRCDFEEDWCGWRD---SGKTTLTWSRHTGSSPTHDTGPDGDHTMQHLQNNT 551
                  |...||..:|.:..:.|...|   ||    ||::.......:...|    |...|:..|
Mouse   528 ------CLSAPYFIQCGWCHNQCVRFDECPSG----TWTQEICLPAVYKVFP----TSAPLEGGT 578

  Fly   552 ----SGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSK--------TFNPPPSVHGNPDSPYRNSC 604
                .|:......|...:..:...::|..|..:.:|:        |..|..|.|
Mouse   579 VLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCTVGPAMSEH----------- 632

  Fly   605 VVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGSDWMRAEYVLPNITSKYYLQFEAR 669
                           .|:||:....:|.             :.:....||.|.|||     ...|
Mouse   633 ---------------FNVSVIISNSRET-------------TQYSAFSYVDPVITS-----ISPR 664

  Fly   670 MGMRIYSDVAVDDFSLSPECFG--LNIPEDHLGGYNYWDVRQNLKSPTYKDFEYTNYLE-LTTCD 731
            .|               |:..|  |.:...:|...|...:....|:.|.|... .:.|| .|...
Mouse   665 YG---------------PQAGGTLLTLTGKYLNSGNSRHISIGGKTCTLKSVS-DSILECYTPAQ 713

  Fly   732 TRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYKGMQKWKVPHEGHYTIIAKGASGGLGSG 796
            |.....|.:.:.:.|.|| ..:...||..||               :|.|.|  ....|||....
Mouse   714 TTSDEFPVKLKIDLANRE-TSSFSYREDPVV---------------YEIHPT--KSFISGGSTIT 760

  Fly   797 GVGSSRGSVAV--AILELHKNEELYFLVGQQGENA---CIKSMGVLKEAGCGTDHDLDLAQYSFR 856
            |:|.:..||::  .::::|:....|.:..|...|:   |..:.. ||:.|.    .|.|...:|
Mouse   761 GIGKTLNSVSLPKLVIDVHEVGVNYTVACQHRSNSEIICCTTPS-LKQLGL----QLPLKTKAF- 819

  Fly   857 SKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAKPL 921
                                    |||:                |: :.::.|..:.|....:|.
Mouse   820 ------------------------FLLD----------------GI-LSKHFDLTYVHNPVFEPF 843

  Fly   922 QAP---ESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVH 983
            :.|   ..|..|...:......|    .|.:.:.|..           |..||        .|:|
Mouse   844 EKPVMISIGNENVVEIKGNNIDP----EAVKGEVLKV-----------GNQSC--------ESLH 885

  Fly   984 RHGQGGFGGGGGGCNTGGGGGGYAGGDVYLTESNGEGGSSYISPSRSLREISEIH-----AGASS 1043
            .|                      .|.|..|           .||..|:..||::     |.:|:
Mouse   886 WH----------------------SGAVLCT-----------VPSDLLKLNSELNIEWKQAVSST 917

  Fly  1044 GPGAIIIIPAIEGCGCDYRCVALDEFRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSI 1108
            ..|.:|:.|.....|.....|:                                        :|:
Mouse   918 VLGKVIVQPDQNFAGLIIGAVS----------------------------------------ISV 942

  Fly  1109 LMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQ-----LTRL-------------- 1154
            :::.|:.||:            :.||::.|.....||..|.:     |.||
Mouse   943 VVLLLSGLFL------------WMRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVS 995

  Fly  1155 ------RNNIDDSNLNNFNPNYGC-----------------DGILNG-------HIDVNSL-PQV 1188
                  |....:....|.:.|..|                 |..::.       |||:::| |::
Mouse   996 NESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPEL 1060

  Fly  1189 ARDSLQLV-----------NALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFL 1242
            .:....:|           ..:|:|.||.||.......||..:.  .|||:|......|:...||
Mouse  1061 VQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIH--CAVKSLNRITDIEEVSQFL 1123

  Fly  1243 KEAAIMAKFNHPNMVHLIGVCF--DRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLF 1305
            .|..||..|:|||::.|:|:|.  :..| .:||..:..|||:.|:|...:.|      |:|||:.
Mouse  1124 TEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLRNFIRNETHNP------TVKDLIG 1181

  Fly  1306 CALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGK--AML 1368
            ..|.||||.:|:.||:|:|||:|||||:|..|   ..||:||||::||:|..:||....|  |.|
Mouse  1182 FGLQVAKGMKYLASKKFVHRDLAARNCMLDEK---FTVKVADFGLARDMYDKEYYSVHNKTGAKL 1243

  Fly  1369 PIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPV 1433
            |:|||..|:.....||:|:||||||:||||:.:.|..|||..:...:...:::|.||..|..||.
Mouse  1244 PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPD 1308

  Fly  1434 SIYKVMADCWNPTPEDRPTFITLLEHLTACTQ----------DASIMN----APLPNIL 1478
            ::|:||..||:|..|.||:|..|:..:::...          :|:.:|    ||.|::|
Mouse  1309 ALYEVMLKCWHPKAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYVNVKCVAPYPSLL 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	28/191 (15%)
		MAM	288..447	CDD:99706	28/188 (15%)
		MAM	505..691	CDD:279023	33/200 (17%)
		MAM	505..689	CDD:99706	33/198 (17%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	112/290 (39%)
		TyrKc	1193..1460	CDD:197581	111/281 (40%)
Met	NP_032617.2	Sema	25..515	CDD:387663	46/303 (15%)
		PSI	518..560	CDD:214655	13/59 (22%)
		IPT_plexin_repeat1	562..655	CDD:238585	18/135 (13%)
		IPT_plexin_repeat2	656..739	CDD:238584	22/104 (21%)
		IPT	741..836	CDD:387656	28/158 (18%)
		IPT_PCSR	838..917	CDD:238337	22/134 (16%)
		PTKc_Met_Ron	1080..1341	CDD:270649	110/272 (40%)
		Interaction with RANBP9. /evidence=ECO:0000250	1210..1379		61/161 (38%)
		Interaction with MUC20. /evidence=ECO:0000250	1318..1357		8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810