DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and Ltk

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_976220.2	Gene:	Ltk / 17005	MGIID:	96840	Length:	888	Species:	Mus musculus

Alignment Length:	878	Identity:	316/878 - (35%)
Similarity:	448/878 - (51%)	Gaps:	130/878 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   729 TCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYKGMQKWKVPHEGHYTIIAKGASGGL 793
            ||...|..||:|.||:.||...:      .:..|......||:|.|:||..|.|.|.|.||:||.
Mouse    72 TCGASGRSGPTQTQCDGAYTGSS------VMVTVGAAGPLKGVQLWRVPDTGQYLISAYGAAGGK 130

  Fly   794 GS-GGVGSSRGSVAVAILELHKNEELYFLVGQQGENAC-----IKSMGVLKEAG-----CGTDHD 847
            |: ..:..:.|....|:..|.:.|.:|.||||||::||     ...:..|.|:|     .||:..
Mouse   131 GAQNHLSRAHGIFLSAVFFLRRGEPVYILVGQQGQDACPGGSPESQLVCLGESGEHATTYGTERI 195

  Fly   848 LDLAQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGG--------LGI 904
            ....:::              .|.|||||.:.:|.|...:.|  |||||.||||        .|.
Mouse   196 PGWRRWA--------------GGGGGGGGATSIFRLRAGEPE--PLLVAAGGGGRSYRRRPDRGR 244

  Fly   905 GQYIDEDFQHGQKAKPLQAPESGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGH 969
            .|.:.|..:     ....||.||...|      .||.|.||.::   |.||..|.:..:|..||.
Mouse   245 TQAVPERLE-----TRAAAPGSGGRGG------AAGGGSGWTSR---AHSPQAGRSPREGAEGGE 295

  Fly   970 SCYVELADNGTSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVY---LTESNGEGGSSYISPSRSL 1031
            .|    |:...::.....||||||||.|..|||||||.|||..   |..::||.|:|::.||
Mouse   296 GC----AEAWAALRWAAAGGFGGGGGACAAGGGGGGYRGGDTSESDLLWADGEDGTSFVHPS--- 353

  Fly  1032 REISEIH---AGASSGPGAIIIIPAIEGCGCDYR-CVALDEFRSKV---RCICPDGWSLKRDNHT 1089
               .|::   ...:.|.|.:.|........|.:: |    ::::::   .|.||:|..|..||.|
Mouse   354 ---GELYLQPLAVTEGHGEVEIRKHPNCSHCPFKDC----QWQAELWTAECTCPEGTELAVDNVT 411

  Fly  1090 ACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRL 1154
            ..::...|   |...|:..::.:||:..:.:.|::.::..:.|....::     |...:|:|::|
Mouse   412 CMDLPTTA---SPLILMGAVVAALALSLLMMCAVLILVNQKCQGLWGTR-----LPGPELELSKL 468

  Fly  1155 RNNIDDSNLNNFNPN-YGCDGILNGHIDVN---------SLPQVARDSLQLVNALGKGAFGEVYM 1209
            |     |:.....|| |.|      .:.::         .|.:|:..::.|:.|||.|||||||.
Mouse   469 R-----SSAIRTAPNPYYC------QVGLSPAQPWPLPPGLTEVSPANVTLLRALGHGAFGEVYE 522

  Fly  1210 ALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLE 1274
            .|.....||:..:.||:|||.|....:.|.|||.||.|::||:|.|:|..:|:.|...|..|:||
Mouse   523 GLVTGLPGDSSPLPVAIKTLPELCSHQDELDFLMEALIISKFSHQNIVRCVGLSFRSAPRLILLE 587

  Fly  1275 LLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGP 1339
            |::|||::.|||.:|..|.:.:.|||:|||..|.|:|:||.|:|...||||||||||||||..|.
Mouse   588 LMSGGDMKSFLRHSRPHPGQLAPLTMQDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCSGA 652

  Fly  1340 GRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGR 1404
            .||.||.||||:||||::.||||||:.:||:|||||||.|:|:||||||.||||:||||:||||.
Mouse   653 SRVAKIGDFGMARDIYQASYYRKGGRTLLPVKWMPPEALLEGLFTSKTDSWSFGVLLWEIFSLGY 717

  Fly  1405 SPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASI 1469
            .||||..|.:|::.:..|.|:..|..||..:|::|..||...||.||.|.::||.:..||||..:
Mouse   718 MPYPGHTNQEVLDFIATGNRMDPPRNCPGPVYRIMTQCWQHQPELRPDFGSILERIQYCTQDPDV 782

  Fly  1470 MNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYLVPLPPGGSNNPSMASG--SGYVPELQRQ 1532
            :|:|||...||...|.:.:  |..|.....|..|.   ||.....|..|...|  ..::|...:.
Mouse   783 LNSPLPVEPGPILEEEEAS--RLGNRSLEGLRSPK---PLELSSQNLKSWGGGLLGSWLPSGLKT 842

  Fly  1533 QMSSCTPPAVTSPAAPHPRPVENI-APTSGDCW 1564
            ....|..|             :|| .||.|. |
Mouse   843 LKPRCLQP-------------QNIWNPTYGS-W 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	145/275 (53%)
		TyrKc	1193..1460	CDD:197581	144/266 (54%)
Ltk	NP_976220.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..294		25/81 (31%)
		PTKc_ALK_LTK	499..775	CDD:270632	145/275 (53%)
		Pkinase_Tyr	506..773	CDD:285015	144/266 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..888		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1192
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	641	1.000	Inparanoid score	I810
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002954
OrthoInspector	1	1.000	-	-		otm44277
orthoMCL	1	0.900	-	-		OOG6_105014
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.820