DRSC/TRiP Functional Genomics Resources

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Protein Alignment Alk and Igf1r

DIOPT Version :10

Sequence 1:NP_652600.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:XP_006540704.1 Gene:Igf1r / 16001 MGIID:96433 Length:1401 Species:Mus musculus


Alignment Length:527 Identity:160/527 - (30%)
Similarity:260/527 - (49%) Gaps:116/527 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly  1063 CVALDEFR----SKVRCICPDGWSLKRDNHTA-CEIREEAGKSSF---------------QYLVS 1107
            ||:..|:|    :|:..:.|       .|:|| .:....:|..|:               .::..
Mouse   881 CVSRQEYRKYGGAKLNRLNP-------GNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHL 938

  Fly  1108 ILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNIDDSNLNNFNPNYGC 1172
            |:.:.:|:|.| :..|:.|||..::::..|               ||.|.:..:::   ||.|  
Mouse   939 IIALPVAILLI-VGGLVIMLYVFHRKRNNS---------------RLGNGVLYASV---NPEY-- 982

  Fly  1173 DGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREK 1237
              .....:.|....:|||:.:.:...||:|:||.||..:.:....|..|..||:||:.|.....:
Mouse   983 --FSAADVYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRE 1045

  Fly  1238 EEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENR---------NTPE 1293
            ..:||.||::|.:||..::|.|:||....||..:::||:..|||:.:||..|         |:..
Mouse  1046 RIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEPRLSWNSLR 1110

  Fly  1294 RP--------------SLLTMKD------------LLFCALDVAKGCRYMESKRFIHRDIAARNC 1332
            ||              .:|.:|.            ::..|.::|.|..|:.:.:|:|||:|||||
Mouse  1111 RPGWPRTLRDSLASVSQVLALKQNNLVLIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNC 1175

  Fly  1333 LLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLW 1397
            :::.   ...|||.||||:||||.:||||||||.:||::||.||:..||:||:.:||||||::||
Mouse  1176 MVAE---DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLW 1237

  Fly  1398 EVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLL----E 1458
            |:.:|...||.|..|.||:..|:.||.|..|..||..::::|..||...|:.||:|:.::    :
Mouse  1238 EIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIKD 1302

  Fly  1459 HLTACTQDASIMNAPLPNILGPTASERDDTVIRPPNGEEFCLAVPDYL--VPLPPGGSNNPSMAS 1521
            .:....|:.|..           .||.:    :||..||..:. |:.:  |||      :||.:|
Mouse  1303 EMEPSFQEVSFY-----------YSEEN----KPPEPEELEME-PENMESVPL------DPSASS 1345

  Fly  1522 GSGYVPE 1528
            .|..:||
Mouse  1346 ASLPLPE 1352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_652600.1 MAM 288..447 CDD:99706
MAM 505..689 CDD:99706
PTKc_ALK_LTK 1186..1462 CDD:270632 115/314 (37%)
Igf1rXP_006540704.1 Recep_L_domain 51..161 CDD:460032
Furin-like 175..330 CDD:395614
Recep_L_domain 353..468 CDD:460032
FN3 494..607 CDD:238020
FN3 612..>656 CDD:238020
FN3 837..926 CDD:238020 11/51 (22%)
PTKc_InsR_like 994..1302 CDD:173625 115/310 (37%)
Blue background indicates that the domain is not in the aligned region.

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