Protein Alignment Alk and Erbb4

DIOPT Version :10

• Sequence 1: NP_652600.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Sequence 2: XP_006495755.1
• Gene: Erbb4 / 13869
• MGIID: 104771
• Length: 1308
• Species: Mus musculus
• Alignment Length: 692
• Identity: 182/692 - (26%)
• Similarity: 283/692 - (40%)
• Gaps: 143/692 - (20%)

  Fly  1056 GCGCDYRCVALDEFRSKVRCI--CPDGW-----------SLKRDNHTA---------------CE 1092
            |.|.| .|.....|:....|:  ||||.           ...|:.|..               |.
Mouse   571 GPGPD-NCTKCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQGCNGPTSHDCI 634

  Fly  1093 IREEAGKSSFQYLVSILMISLAV---LFI-CIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTR 1153
            .....|.|:........:|:..|   ||| .|.||.|.:|.|  ||...|||            .
Mouse   635 YYPWTGHSTLPQHARTPLIAAGVIGGLFILVIMALTFAVYVR--RKSIKKKR------------A 685

  Fly  1154 LRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGD 1218
            ||..::...:....|:    |.......:..|.:.   .|:.|..||.||||.||..:: ..:|:
Mouse   686 LRRFLETELVEPLTPS----GTAPNQAQLRILKET---ELKRVKVLGSGAFGTVYKGIW-VPEGE 742

  Fly  1219 AVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQK 1283
            .|::.||:|.|.|....:...:|:.||.|||..:||::|.|:|||.. ....:|.:|:..|.|..
Mouse   743 TVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS-PTIQLVTQLMPHGCLLD 806

  Fly  1284 FLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADF 1348
            ::.|:::......||.     :| :.:|||..|:|.:|.:|||:||||.|:  |.|.. |||.||
Mouse   807 YVHEHKDNIGSQLLLN-----WC-VQIAKGMMYLEERRLVHRDLAARNVLV--KSPNH-VKITDF 862

  Fly  1349 GMSRDIY--RSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQH 1411
            |::|.:.  ..:|...|||  :|||||..|......||.::||||:|:.:||:.:.|..||.|..
Mouse   863 GLARLLEGDEKEYNADGGK--MPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIP 925

  Fly  1412 NTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPN 1476
            ..::.:|:.:|.||..|..|.:.:|.||..||....:.||.|..|....:...:|      |...
Mouse   926 TREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARD------PQRY 984

  Fly  1477 ILGPTASERDDTVIRP-PNGEEF------------CLAVPDYLVP----LPPGGSNNPSMASGSG 1524
            ::    .:.||.:..| ||..:|            .:...:||||    :||     |...|.:.
Mouse   985 LV----IQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPP-----PIYTSRTR 1040

  Fly  1525 YVPELQRQQMSSCTPPAVTSPAAPHPRPVENIAPTSGDCW---ETSFILPNSKVEP--PVVGSGH 1584
            .  :..|.::....|||.|              |.||:.:   :..|........|  ....:..
Mouse  1041 I--DSNRSEIGHSPPPAYT--------------PMSGNQFVYQDGGFATQQGMPMPYRATTSTIP 1089

  Fly  1585 DVPLAGGEEAKLI-------SLDTPQPTPTTIQPPLSFASQLDGITLDPSALT-KSLPNGNAKQS 1641
            :.|:|.|..|::.       :|..|      :.|.:...|.....:.||:... :..|.|...:.
Mouse  1090 EAPVAQGATAEMFDDSCCNGTLRKP------VAPHVQEDSSTQRYSADPTVFAPERNPRGELDEE 1148

  Fly  1642 YANVQVKNEAEAKVINGVVGNGTV---MNGDVSTGSGGADSP 1680
            .....:.::.:.:.:|.|..|..|   .|||:.    ..|:|
Mouse  1149 GYMTPMHDKPKQEYLNPVEENPFVSRRKNGDLQ----ALDNP 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_652600.1	MAM	288..447	CDD:99706
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	99/277 (36%)
Erbb4	XP_006495755.1	Recep_L_domain	55..167	CDD:460032
		Furin-like	186..332	CDD:395614
		Recep_L_domain	358..478	CDD:460032
		GF_recep_IV	502..634	CDD:464344	12/63 (19%)
		TM_ErbB4	642..685	CDD:213053	17/56 (30%)
		PTKc_HER4	710..1012	CDD:173655	108/327 (33%)