DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and Malrd1

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	NP_001297384.1	Gene:	Malrd1 / 102635496	MGIID:	1928271	Length:	2123	Species:	Mus musculus

Alignment Length:	1168	Identity:	242/1168 - (20%)
Similarity:	363/1168 - (31%)	Gaps:	399/1168 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   288 CNFETP--CSW---------------TWGNYSDGFQVITGTELSKRNLTGLLPGPAAD-SIDDAN 334
            |.||..  |.|               .|| ..:|..:..|.|..:         |:.| :.:..:
Mouse  1056 CTFEERKLCKWYQPIPANSLHDSNTFRWG-LGNGISIHHGEENHR---------PSVDHTKNTTD 1110

  Fly   335 GHFLYARVNPSSRP-----LNLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVVELLHTAESSWV 394
            |.:|||   .||..     .::.:|..|....:|.|..:.:.:..:.|..:|::::.:|....|.
Mouse  1111 GWYLYA---DSSNGKFGDLADIVTPVISLMGPRCTLVFWTYMNGATVGSLQVLIKMGNTISKVWA 1172

  Fly   395 PAEILGDNVRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCS 459
            .:   |....||.:....|| :.....|||..  ...|...|.||:|::...||.|..:.:.||:
Mouse  1173 QS---GQQGPQWKKAEVFLG-IHSHVEIVFRA--KRGVSYIGDVAVDDVSFQNCSPLLSTNRKCT 1231

  Fly   460 TSQVKCTSSKVPVCIHLPRICDITRDCDEAEDEQQ-SCDKIPYGGRCDFEEDWCGWRDSGKTTLT 523
            |.:..|.:..   ||...::||...||.:..||.. .|.  ...||||||.|.|.|.......:.
Mouse  1232 TDEFMCANKH---CIEKDKLCDFVNDCADNSDETTFICG--TSSGRCDFEFDLCTWEQDQDEDID 1291

  Fly   524 WSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNP 588
            |:....:.|...|.|..|||:    .|:||:|:::                         |:|.|
Mouse  1292 WNLKASNIPATSTEPAVDHTL----GNSSGHYIIL-------------------------KSFFP 1327

  Fly   589 -PPSVHGNPDSPY----RNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGSDW 648
             .|...|...||.    ...|.:.|..|.:|....::.|..|.:   .|.|..|...||.||:.|
Mouse  1328 QQPVKTGRISSPVISKRSKDCKIIFNYHMYGSGIAALLLLQVTV---TNHTRVLLNLTKEQGNFW 1389

  Fly   649 MRAEYVLPNITSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYNYWDVRQNLKS 713
            .|.|..|.: ...:.::||.|:|..|..::|:||..|:..|    :|..|       ..|:....
Mouse  1390 QRKELSLSS-DEDFRVKFEGRVGEGIRGNIALDDIVLTKSC----LPSHH-------STREEPAF 1442

  Fly   714 PTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSS-------YKGM 771
            |....|          |..    |..:.|....|..:.:.:.:.:.....|::.       .||.
Mouse  1443 PLPTGF----------CPR----GYEECQNGRCYSPEQRCNFVDDCGDNSDENECGGSCTFEKGW 1493

  Fly   772 QKWKVPHEGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFL------VGQQGENAC 830
            ..||       ..:|:.:...||.|...|.|......:    .||..:|:      ||..|:.|.
Mouse  1494 CGWK-------NSLAENSDWVLGIGSYKSQRPPKDHTL----GNEHGHFMYLEATPVGLHGDKAH 1547

  Fly   831 IKSMGVLKE--AGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAG------------GGGGGSYVF 881
            .|| ...:|  |.|....     .|...:|......|.|:...|            |........
Mouse  1548 FKS-ATWQESSAACTMSF-----WYFISAKATGSIQILIKTDKGLWEVWQQSKPDPGNHWRRATI 1606

  Fly   882 LLNQAKN-----EAVPLLVAGGGGGLG---------IGQYID-----EDFQHGQK---AKPL--- 921
            ||.:.:|     :.:.....|||..:.         :|:..|     .||....|   |..|
Mouse  1607 LLGKLRNFEVIFQGIRTRDLGGGAAIDDIEFNNCTTVGETTDICSEETDFLCQDKKCIASHLVCD 1671

  Fly   922 QAPESGQINGEP---LNKKTAG------PGGGWRAK-------EDQ------ALSPTYGAALLQG 964
            ..|:....:.|.   ....|||      ..|.|..:       ||.      ::.||.|.:....
Mouse  1672 YKPDCSDTSDEAHCGYYTSTAGSCNFETTSGDWTVECGLTQDPEDDLDWSIGSIIPTEGLSRDSD 1736

  Fly   965 ---GRGGHSCYV--ELADNGTSVHRHGQGGFGGGGGGC--------------------------- 997
               |.|.|..||  .||:.|::........|....|.|
Mouse  1737 HTPGSGRHFLYVNTSLAEEGSTARIITSHFFPASLGICTVRFWFYMVDPHIVGILKVYLIEKSGL 1801

  Fly   998 -----------NTGGGGGGYA------------------GG---------DVYLTESNGEGGSSY 1024
                       ||   |..||                  ||         |:..|.:...||.:.
Mouse  1802 NILMWSMMRNKNT---GWTYAHVPLSSNSPFKVAFEADLGGKEDIFIALDDITFTPTCASGGPAL 1863

  Fly  1025 ISPSRSLREISE---IHA-----------------------GASSGP------------------ 1045
              |...|.|..:   |:|                       ..|.||
Mouse  1864 --PQPPLCEEGQFACIYALQCVSASEKCDGQEDCIDGSDEMNCSLGPSPQPCSDTEFQCFESQCI 1926

  Fly  1046 ----------------------------GAI------IIIPAIEGCGCDYRC--VALDE------ 1068
                                        ||:      :.|||.:.|.....|  :.:||
Mouse  1927 PSLLLCDGVADCQFNEDESSCVNQSCPSGALACNSSGLCIPAHQRCDGTAHCKDIQVDESSCSEC 1991

  Fly  1069 ----FRSKVRCI---------CPDGWSLKRDNHTACEIRE----EAGKSSFQYLVSILMISLAVL 1116
                .|:...|:         |..||:..|     |.||.    |....:..|:.::|.|.|..|
Mouse  1992 PIHYCRNGGTCVIENIGPTCRCVQGWTGNR-----CHIRSNLSTEGSVHTQNYIWTLLGIGLGFL 2051

  Fly  1117 FICIAALIFM---LYNRYQRKKQSKKRHKMLVEQDLQLTRLRNNID----DSNLNNF-NPNYG 1171
            ...||..|..   :..|..||.:....|..:...      .||.|:    .|::.:| ||.||
Mouse  2052 LTHIAVAILCSLGIRRRPMRKSEGVGNHSFINPV------YRNCINQEKTQSSIYSFPNPFYG 2108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	41/184 (22%)
		MAM	288..447	CDD:99706	39/181 (22%)
		MAM	505..691	CDD:279023	52/190 (27%)
		MAM	505..689	CDD:99706	51/188 (27%)
		PTKc_ALK_LTK	1186..1462	CDD:270632
		TyrKc	1193..1460	CDD:197581
Malrd1	NP_001297384.1	LDLa	38..67	CDD:238060
		MAM	73..226	CDD:279023
		MAM	73..226	CDD:99706
		MAM	236..384	CDD:279023
		MAM	236..384	CDD:99706
		MAM	443..601	CDD:99706
		MAM	443..600	CDD:279023
		MAM	620..782	CDD:279023
		MAM	620..779	CDD:99706
		LDLa	792..825	CDD:238060
		MAM	831..990	CDD:279023
		MAM	831..987	CDD:99706
		LDLa	1016..1051	CDD:238060
		MAM	1056..1222	CDD:279023	41/184 (22%)
		MAM	1056..1219	CDD:99706	39/181 (22%)
		LDLa	1229..1261	CDD:197566	10/34 (29%)
		MAM	1273..1426	CDD:279023	50/185 (27%)
		MAM	1273..1426	CDD:99706	50/185 (27%)
		LDLa	1449..1483	CDD:238060	5/37 (14%)
		MAM	1487..1639	CDD:279023	34/168 (20%)
		MAM	1487..1639	CDD:99706	34/168 (20%)
		LDLa	1653..1685	CDD:238060	7/31 (23%)
		MAM	1695..1855	CDD:279023	27/162 (17%)
		MAM	1695..1855	CDD:99706	27/162 (17%)
		LDLa	1869..1904	CDD:238060	3/34 (9%)
		LDLa	1913..1947	CDD:238060	0/33 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900