Protein Alignment Alk and alk

DIOPT Version :9

• Sequence 1: NP_001261027.1
• Gene: Alk / 53425
• FlyBaseID: FBgn0040505
• Length: 1701
• Species: Drosophila melanogaster
• Sequence 2: XP_031758085.1
• Gene: alk / 100495071
• XenbaseID: XB-GENE-490262
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 1501
• Identity: 475/1501 - (31%)
• Similarity: 677/1501 - (45%)
• Gaps: 306/1501 - (20%)

  Fly   274 ATPSSEYEYELGVKCNFETPCSWTWGNYS------DGFQVITGTELSKRNLTGLLPGPAAD-SID 331
            |||.:.:.::    ||||:||..   .||      ..:::.|..||.:|.   :..||..| |.:
 Frog     8 ATPRTRHNFD----CNFESPCDL---EYSLPPYGAKAWRIATAEELLQRY---IFSGPPGDYSEN 62

  Fly   332 DANGHFLYARVNPSSRPLNLTSPEFSTTMEKCFLE--VYMHQSDMSHG----LSRVVVELLHT-- 388
            ...|||||...:.:..|: |.||...::...|.:|  ||..::....|    ::|...|:|.|
 Frog    63 STTGHFLYLNASTAHNPI-LLSPWLKSSSRNCLVEVAVYTQKNGRYIGHVQPINRTSYEVLFTPR 126

  Fly   389 -AESSWVPAEILGDNVRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHV-ALDNLRMVNCFPE 451
             .::.||  ::.|           .:|.:.|.|||..|.|.:    ::|.| |:|:..:.||...
 Frog   127 QKKTGWV--QLRG-----------VIGHMERPFRISLEYVAE----ERGTVAAVDSFAIRNCSQG 174

  Fly   452 GTKSEKCSTSQV-KCTSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGWR 515
            .....|.:...| .|.:.   :.|.|.::|:...||:|.|||...|..:|.|..|.|||..|||.
 Frog   175 NLSGLKMALDGVFNCRNG---MAIKLRQVCNFIPDCEEEEDEGDLCRNLPPGFYCMFEEGSCGWA 236

  Fly   516 DSGKTTLTWSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAI 580
            .....:.......|.||                    |..:.:|    ::||:.      |:..:
 Frog   237 LDHLNSRWQVGSVGKSP--------------------GSVLYLN----VSNSKS------AARDV 271

  Fly   581 MVSKTFNPPPSVHGNPDSPYRN-SCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQ 644
            :.|..|          .:|.:| ||.:|......|...|:|::.:|:.|..:..|..||.....:
 Frog   272 LSSVLF----------PAPLKNSSCELRMSFLLKGFLLGNISVLLVDNKTGKVRTRPLWSFENGE 326

  Fly   645 G-SDWMRAEYVLPNI-----TSKYYLQFEARMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYN 703
            | ..|......|.::     :.:::|:..........|.:|.|:.|||..|:..:..|..|...:
 Frog   327 GLGVWQHIVLYLKDVMERFRSHRFWLEIHTSWAQESDSIIAFDNVSLSLGCYLTSNGELPLQTVS 391

  Fly   704 YW-------------------DVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYRE 749
            |.                   :..::|.|..:.......|...|||...|..||||..|:..|
 Frog   392 YLSSNLLMESSNQRLNDTEGDEQEEDLNSGLHPSSAGAGYWHFTTCGATGPYGPSQKLCDDTY-- 454

  Fly   750 QNKTHVLREVHVVEDQSSYKGMQKWKVPHEGHYTIIAKGASGGLGSGGVGSSRGSVAVAILELHK 814
                   :...|.......||:|.|:||....|.|...||:||.|......::|...:.|.||.|
 Frog   455 -------KNFSVEMGTGGLKGVQMWRVPETNTYRISGYGAAGGNGGKTPTLAQGISLIGIFELQK 512

  Fly   815 NEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFRSKQDMVKNIYIENGAGGGGGG-- 877
            :|.||.||||:||:||.::..||:....|.:.:::         .::..|..:...|||||||
 Frog   513 DEILYILVGQKGEDACPRANSVLQMVCIGENTEIE---------DELRINGSVSEWAGGGGGGGG 568

  Fly   878 -SYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHGQKAK--PLQAPESGQ----INGEPLN 935
             :|||.:...|  .||||:|.||||..          :..||.  |.:..||..    :||:
 Frog   569 ATYVFKMESGK--PVPLLIAAGGGGRA----------YRSKASVIPPERLESNYTIPGMNGK--- 618

  Fly   936 KKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNGTSVHRHG---QGGFGGGGGGC 997
            ...||.||||   .|....|..|.:|::|..||.||       ..:|.:.|   :||||||||||
 Frog   619 SGAAGGGGGW---NDHTALPWAGKSLMEGAIGGESC-------PQAVKKWGWETRGGFGGGGGGC 673

  Fly   998 NTGGGGGGYAGGDV---YLTESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIP--AIEGC 1057
            ::|||||||.||:.   ...|.:|..|.|:|||.                 |.:...|  .|||.
 Frog   674 SSGGGGGGYIGGNAAEGNSAEMDGLEGVSFISPR-----------------GVVYTPPLKVIEGH 721

  Fly  1058 G------------CDYRCVALDEFRSKVRCICPDGWSLKRDNHTACEIREEAGKSSFQYLVSILM 1110
            |            |:.....||....::.|:|..|..|..|. .:| |.|....:...:|...|:
 Frog   722 GEVEIKLHLNCSHCEMDECLLDPESKRIVCLCERGTVLAEDG-VSC-IDEALAPAQETHLPLSLV 784

  Fly  1111 ISLAVLFICIAALI-----FMLYNRYQRKKQSKKRHKM-LVEQDLQLTRLRNNIDDSNLNNFNPN 1169
            :|: |....:||||     .|:.  |::|.|..:..:| |...|.:|:::|.:   :.:.::|||
 Frog   785 LSI-VTSALVAALILAFSGIMIV--YRKKHQELQAIQMELQSPDYKLSKVRTS---TIMTDYNPN 843

  Fly  1170 YGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPK 1234
            |...|.:.   .:..|.:|.|.::.|:..||.|||||||.........|...:.||||||.|...
 Frog   844 YCFAGKVT---SIGDLKEVPRKNISLIRGLGHGAFGEVYEGQVLGTPSDPNPLKVAVKTLPEVCS 905

  Fly  1235 REKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLT 1299
            .:.|.|||.||.|::||:|.|:|..|||.....|.:|:|||:|||||:.|||:.|....:||.:|
 Frog   906 EQDELDFLMEALIISKFSHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRQTRPRLNQPSSIT 970

  Fly  1300 MKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGG 1364
            |.|||..:.|:|:||:|:|...|||||||||||||:.:|.|||.||.||||:|||||:.||||||
 Frog   971 MLDLLNVSCDIAQGCKYLEENHFIHRDIAARNCLLTCQGSGRVAKIGDFGMARDIYRASYYRKGG 1035

  Fly  1365 KAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPT 1429
            .||||:||||||||::||||||||.||||:||||:||||..|||.:.|.:|:|.|..|||:..|.
 Frog  1036 CAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPK 1100

  Fly  1430 ECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILGPTASERDDTVIRPPN 1494
            .||..:|::|..||...|||||.|..:||.:..|.||..::|..||...||...:.:...:|..:
 Frog  1101 NCPGPVYRIMTQCWQHQPEDRPNFAIILERINYCKQDPDVINTSLPVEYGPVVEDEEKAPVRSDD 1165

  Fly  1495 GEEFCLAVPDYLVP--------LPPGGSNNPSMASGSGYVPELQRQQMSSCTPPAVTSPAAP--- 1548
            .:    .:|..|||        |.|..|..|...:..|.:|....      |.|.|.:.:.|
 Frog  1166 PD----VIPPALVPPEKPIKDDLQPLRSPPPVPPNPRGKIPNKVH------TEPRVPAKSRPEGG 1220

  Fly  1549 --HPRPVENIAPTSGDCWETSFILPNSKVE------------PPVVGS---GHDVPLAGGEEAKL 1596
              |...|              |..||.:.|            .|..||   |..|....|...|
 Frog  1221 GGHDNAV--------------FARPNPQAELRGSRNKPTNLWNPTYGSWFTGKTVVKTPGPPDK- 1270

  Fly  1597 ISLDTPQPTPTTIQPPLSF------------ASQLDG--ITLDPSALTKSL-----------PNG 1636
                   |||....||.|.            .|:|.|  :.|:||.||.::           |.|
 Frog  1271 -------PTPEKENPPSSVTEGNCTAANRVAGSRLPGSSLLLEPSTLTSNVQEVPLFRLRHFPCG 1328

  Fly  1637 NAKQSY 1642
            .....|
 Frog  1329 TVNYGY 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	50/178 (28%)
		MAM	288..447	CDD:99706	48/175 (27%)
		MAM	505..691	CDD:279023	41/192 (21%)
		MAM	505..689	CDD:99706	40/190 (21%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	153/275 (56%)
		TyrKc	1193..1460	CDD:197581	151/266 (57%)
alk	XP_031758085.1	MAM	18..172	CDD:421533	49/177 (28%)
		MAM	226..376	CDD:421533	40/189 (21%)
		PTKc_ALK_LTK	857..1133	CDD:270632	153/275 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I1203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	612	1.000	Inparanoid score	I899
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27151at33208
OrthoFinder	1	1.000	-	-		FOG0002954
OrthoInspector	1	1.000	-	-		otm49452
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4020
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060