DRSC/TRiP Functional Genomics Resources

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Protein Alignment Alk and malrd1

DIOPT Version :9

Sequence 1:NP_001261027.1 Gene:Alk / 53425 FlyBaseID:FBgn0040505 Length:1701 Species:Drosophila melanogaster
Sequence 2:NP_001274478.1 Gene:malrd1 / 100148465 ZFINID:ZDB-GENE-140106-257 Length:1793 Species:Danio rerio


Alignment Length:997 Identity:213/997 - (21%)
Similarity:353/997 - (35%) Gaps:282/997 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 PSSEYEYELGVKCNFET-PCSWTWGNYSDGFQVITGTELSKRNLTGLL------PGPAADSIDDA 333
            |:.|.|.....:|:||: .|.|......|||:.:.|      :..|:.      ..|...:.:.:
Zfish   258 PNGEDEANCSAQCDFESDSCGWYEFFLGDGFEWVRG------SANGVFTEHLDQTPPQDHTTNTS 316

  Fly   334 NGHFLYARVNPS--SRPLNLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVVELLHTAESSWVPA 396
            .|||::.....|  |:...|.||.|..:...|.:..:.:.|..|.|.:.:.: |:..::|.....
Zfish   317 EGHFMFIFKKSSRFSQQALLRSPTFQQSGSDCVMTFWHYNSGHSVGAAEMHL-LIDGSDSITTLW 380

  Fly   397 EILGDNVRQWTRKVYRLGRVSRDFRIVFEVVPDLRVGQKGHVALDNLRMVNC-FPEGTKSEKCST 460
            :.|.:...||...|.::||.:|.|.|.|..: .|.| .:|..|||::...|| .||..  |.|:|
Zfish   381 QTLYNQGNQWHPVVVQIGRQNRPFYISFAKL-SLAV-YEGVSALDDIIFHNCSLPEAV--ETCAT 441

  Fly   461 -SQVKCTSSKVPVCIHLPRICDITRDCDEAEDEQQSCDKIPYGGRCDFEEDWCGW-RDSGKTTLT 523
             ..:.|..||  .|:...:|||:..||.:..||:....::    .|||||..|.| :|..:....
Zfish   442 PDHLHCGQSK--ACVSYSQICDLIDDCGDGTDEENCLPEL----MCDFEEGLCNWTQDHEEDMFD 500

  Fly   524 WSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNP 588
            |:...|.:||.:|||..|||    :.:..|:::.:         |.:....|...|:::|:.|.|
Zfish   501 WTHIQGPTPTFNTGPWKDHT----RASADGHFLYI---------ESSDPQKFKDTAVLISQPFLP 552

  Fly   589 PPSVHGNPDSPYRNSCVVRFFIHQFGK------------NPGSINLSVVEMKEKENITTTLWWST 641
            .|.....|..|    ||.||..|.||:            |.|..||              ||...
Zfish   553 TPRRGPEPKPP----CVFRFHYHMFGQHVFCLAVYMRTSNSGRGNL--------------LWVRY 599

  Fly   642 KNQGSDWMRAEYVLPNITSKYYLQF--EARMGMRIYSDVAVDDFSLSPECFGLNIPEDHLGGYNY 704
            .:||:.|.|   .:..|.|.::.|.  |..:|.....|:|:||.|.    :|....|..|     
Zfish   600 GDQGNFWHR---TILEINSSHHFQILVEGTVGDDFRGDIAIDDLSF----YGCQSYEGEL----- 652

  Fly   705 WDVRQNLKSPTYKDFEYT------------NYLELTT---------CDTRGMIGPSQAQ--CEAA 746
                 .|:.|:......|            .::.|||         ||.|.....|..:  |...
Zfish   653 -----PLEEPSTSAPVPTLSTAPSHSCPPDQFVCLTTRECVNLSQVCDFRPDCSDSSDEELCVKE 712

  Fly   747 YREQNKTHV----LREV--HVVEDQ-----SSYKGMQKWKVPH-------EGHYTIIAKGASGGL 793
            |.:.....:    |.|:  |....|     |.:.|.:|.:..:       ||.| :....::||.
Zfish   713 YCDFEGDSLCGWYLSEIPPHAFSWQTGQGLSIHHGEEKHRPANDHTLGSPEGWY-VFVDSSNGGY 776

  Fly   794 GSGGVGSSRGSVAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFRSK 858
            |                  |..:.|         .|.||..|    ..|..:....::.::..|.
Zfish   777 G------------------HTTDLL---------TAPIKITG----PQCTLEFWYHMSGFTVGSL 810

  Fly   859 QDMVKN------IYIENGAGGGG---GGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQH 914
            |.::|:      ::.::|:.|..   |..::.:.:.     :.:::....|...:|..:.:|...
Zfish   811 QVLIKSGAVAYEVWSQSGSQGNSWRRGEVFIGIRHN-----IQVVLRAKRGISYMGDVVVDDVAF 870

  Fly   915 GQKAKPLQAPESGQ------INGEPLNKKT-------AGPGG---------------------GW 945
            ...|.|:.:....|      .||..:|:..       .|.|.                     .|
Zfish   871 VDCAPPVMSDLPCQNNEFICANGHCINEANLCDFIDHCGDGSDENHYICKGFSGRCNFEFDLCSW 935

  Fly   946 RAKED--------------QALSPTYGAALLQGGRGGHSCYVELADNGTSVHRHGQGG--FGGGG 994
            |..:|              ..:.|:....|  ....||..|:|.:...|:.|.....|  |....
Zfish   936 RQSQDDDFDWLIKPGNMNTHGIGPSTDHTL--RNPSGHYLYLEGSFPQTTGHTARIFGPLFRRCS 998

  Fly   995 GGCN----TGGGGGGYAGGDVYLTESN---------GEGGSSY------ISPSRSLREISEIHAG 1040
            ..|.    ....|.|....:||::.::         |..|:.:      ::.|...|.:.|...|
Zfish   999 KDCKMVFYVHMSGDGIGTLNVYMSSNSSNSLLLNLIGNQGNYWSRQEVPLASSDDFRIMFEGKVG 1063

  Fly  1041 ASSGPGAIIIIPAIEGCGCDYR----CVALDEFRSKVRCI---CPDGWSLKRDN------HTACE 1092
            .::|         :..|..|..    |:..:.|..:.|.:   ||.| ||:.||      ...|:
Zfish  1064 RNTG---------VHICLDDITFSSDCILSNTFEKESRLLTGSCPSG-SLQCDNGNCYKPEQKCD 1118

  Fly  1093 IRE---------EAGKS-SFQY 1104
            ..:         |.|.| ||::
Zfish  1119 FTDDCEDGTDELECGTSCSFEH 1140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AlkNP_001261027.1 MAM 288..450 CDD:279023 44/171 (26%)
MAM 288..447 CDD:99706 42/167 (25%)
MAM 505..691 CDD:279023 55/200 (28%)
MAM 505..689 CDD:99706 55/198 (28%)
PTKc_ALK_LTK 1186..1462 CDD:270632
TyrKc 1193..1460 CDD:197581
malrd1NP_001274478.1 LDLa 22..56 CDD:238060
MAM 62..215 CDD:279023
MAM 62..215 CDD:99706
LDLa 232..266 CDD:238060 3/7 (43%)
MAM 270..432 CDD:279023 44/170 (26%)
MAM 270..429 CDD:99706 42/167 (25%)
LDLa 441..475 CDD:238060 12/35 (34%)
MAM 481..642 CDD:279023 54/194 (28%)
MAM 481..642 CDD:99706 54/194 (28%)
LDLa 674..709 CDD:238060 7/34 (21%)
MAM 714..861 CDD:99706 27/183 (15%)
MAM 714..856 CDD:279023 26/178 (15%)
LDLa 883..916 CDD:238060 6/32 (19%)
MAM 926..1081 CDD:279023 27/165 (16%)
MAM 926..1081 CDD:99706 27/165 (16%)
LDLa 1098..1132 CDD:238060 8/34 (24%)
MAM 1136..1298 CDD:279023 2/5 (40%)
MAM 1136..1297 CDD:99706 2/5 (40%)
LDLa 1297..1332 CDD:238060
MAM 1339..1496 CDD:279023
MAM 1339..1496 CDD:99706
LDLa 1512..1547 CDD:238060
LDLa 1561..1595 CDD:238060
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1095
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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