DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and mst1rb

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	XP_009304468.1	Gene:	mst1rb / 100134855	ZFINID:	ZDB-GENE-071218-3	Length:	1374	Species:	Danio rerio

Alignment Length:	1310	Identity:	293/1310 - (22%)
Similarity:	460/1310 - (35%)	Gaps:	376/1310 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   350 NLTSPEFSTTMEKCFLEVYMHQSDMSHGLSRVVVELLHTAESSWVPAEILGDNVRQWTRKVYRLG 414
            ||.|..|.|.:.:    :..|:.:|.. ...:|:|.                   ::..|..|..
Zfish   260 NLDSSPFQTRLGR----LPRHEWEMRR-YREIVLEC-------------------RFEPKRRRRS 300

  Fly   415 RVSRDFR-IVFEVVPDLRVGQKGHVALDNLRMVNCFPEGTKSEKCSTSQVKCTSSKVPVCIHLPR 478
            .||..|: :|:.||.....|:.|....|.|        |.:.|......|...:....|..|...
Zfish   301 NVSEPFKDVVYNVVQAAHFGKAGRELADEL--------GAEEEDDILYGVFAVTDDSGVPEHDSA 357

  Fly   479 IC------------DITRDCDEAEDEQ--------QSCDKIPYGGRCDFEEDWCGWRDSGKTTLT 523
            :|            |...||.::..||        |.|:..|:              :|.:..:|
Zfish   358 LCAFPMDTVNTAIDDGVEDCCKSGPEQLSRGLCHFQPCESCPH--------------ESMEHNMT 408

  Fly   524 WSRHTGSSPTHDTGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGFASNAIMVSKTFNP 588
            ...|    ||....|               ||.:...|:.|.        |....:::|:...|.
Zfish   409 CRDH----PTLVAQP---------------YYRVDLFNRQMR--------GVLLTSLLVTSIENK 446

  Fly   589 PPSVHGNPDS-----PYRNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQ---- 644
            ..:..|..|.     ..|.|..:.|           .|.|:|   |.:.:::|....::|.
Zfish   447 TVAHIGTSDGRLLQLVLRRSSPIIF-----------ANYSLV---ENQKVSSTAAVLSQNHLLFV 497

  Fly   645 -GSDWMRAEYVLPN----ITSKYYLQFEARMGMRIYSDVAVDDFSLSPEC--------------- 689
             |...:|.....|.    :|....|.....||....|    ...:.:.||
Zfish   498 VGDKMIRVPQRGPGCRHFLTCAMCLTAPKFMGCGWCS----GQCTWASECRAHWVNESCPPVITE 558

  Fly   690 -FGLNIPED-----HLGGYNYWDVRQNLKSPTYKDFEYTNYLELTTCDTRGMIGPSQAQCEAAYR 748
             |....|.|     .|.|   |:.:..|: |...    |...|:...:|..::.|.::.|
Zfish   559 FFPKTAPPDGQSELTLCG---WEFQSPLR-PAIS----TRTHEVKLGETACVVQPHKSNC----- 610

  Fly   749 EQNKTHVLREVHVVEDQSSYKGMQKWKVPH----EGHYTIIAKGASGGLG---------SGGVGS 800
                ||:|.::.....::.:|.:......|    ||||:|.......|..         ....|.
Zfish   611 ----THLLCKIRSGTTETLFKPLNVTAKVHEGQVEGHYSIDGSAEMPGFTFVVPNITEVQPDYGP 671

  Fly   801 SRGSVAVAI----LELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDLAQYSFRSKQDM 861
            ..|...:.|    |:..||.:    |...||:..::|:.|.:    |....:..........:|:
Zfish   672 VDGGTLITITGPYLDSGKNRK----VTLDGESCPVQSVSVAR----GNLSSIVCLSQPVTEVKDV 728

  Fly   862 VKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVA-------GGGGGLGI-GQYIDEDFQ----- 913
            |..:||:.        |.|......:.:..|.::|       ..|..:.| |:.:|..::
Zfish   729 VLRVYIDK--------SRVMTTKVFRYKKTPEILAVLPDCSFDSGSRIIIEGRNLDSVYRTVVYF 785

  Fly   914 --------------HGQKAKPLQA-------PESGQINGEPLNKKTAGPGGGWRAKEDQALSPTY 957
                          .| ||||.:.       |......|| |:....|..|.|  |.|.:..| |
Zfish   786 KPKESHLKPVSTECRG-KAKPTRMECITPVFPRDETEEGE-LSFDMDGVLGLW--KHDFSYHP-Y 845

  Fly   958 GAALLQGGRGGHSCYVELADNGTSVHRHGQGGFGG--------GGGGCNTGGGGGGYAGGDVYLT 1014
            |.. :.....||...:....:..|:|.........        |...|          ||.|...
Zfish   846 GKP-IPFETEGHILRLYPGFDEVSLHHQKLNLVSSCMSITMTVGDVDC----------GGKVLDN 899

  Fly  1015 ESNGEGGSSYISPSRSLREISEIHAGASSGPGAIIIIPAIEGCGCDYRCVALDEFRSKVRCICPD 1079
            |......::...||..| .:.....|.:...|.:|::
Zfish   900 EITCRIPNNLTIPSEGL-PVKVTVNGYTHNVGTVILV---------------------------- 935

  Fly  1080 GWSLKRDNHTACEIREEAGKSSFQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKML 1144
                  .||               |:|.|::..||.|.........:|.|..::||.|:..:::
Zfish   936 ------SNH---------------YMVGIVLGILAALVTGAVLAFIVLKNLRKQKKASQTENRL- 978

  Fly  1145 VEQDLQLTRLRNN-IDDSNLNNFNPNYGCDGI-------------LNGHIDVNSLPQVARDSLQL 1195
              .....:|.||| :|.|:|.::..:.....|             ..|.:|....|.:..:.:.:
Zfish   979 --SYFSHSRSRNNSVDLSSLVDYRRDLPLTSITAPTGAVAFPGLAYTGTLDTTLTPLMPPEKISI 1041

  Fly  1196 VN-------------------------ALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKR 1235
            .:                         .:|||.||.||....  .|.:..|:..|||:|......
Zfish  1042 TSFRPELLEEVKDVLIPASTLKVHHHQIIGKGHFGTVYHGYL--TDHNNREIHCAVKSLNRITDV 1104

  Fly  1236 EKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPY-YIVLELLAGGDLQKFLR-ENRNTPERPSLL 1298
            |:.|.||||..:|..|:|.|::.|:|:....:.. .:||..:..|||:.|:| ||||.
Zfish  1105 EEVEQFLKEGILMKGFHHSNVLSLLGILLPEEGLPLVVLPYMKHGDLRHFIRCENRNP------- 1162

  Fly  1299 TMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYY--R 1361
            |:|||:...|.||||..|:..|:|:|||:|||||:|..   ...||:|||||:||:...:||  :
Zfish  1163 TVKDLIGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDE---SYTVKVADFGMARDVLEKEYYSVQ 1224

  Fly  1362 KGGKAMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLG 1426
            ...||.||:|||..|:.....||:|:||||||:|:||:.:.|.||||......|...:::|.||.
Zfish  1225 DHRKAKLPVKWMAIESLQTQKFTTKSDVWSFGVLMWEMLTRGASPYPEVDPYDVTHYLLKGRRLP 1289

  Fly  1427 SPTECPVSIYKVMADCWNPTPEDRPTFITLL------------EHLTACTQDASIMNAPLP-NIL 1478
            .|..||..::.:|..||:|.||.||:|.||:            ||..:.......::.|.| ..|
Zfish  1290 QPQYCPDPLFAIMLQCWDPDPEKRPSFSTLVSAVMSILSSLEGEHYISLKVTYVNLDQPRPYPAL 1354

  Fly  1479 GPTASERDDT 1488
            ..:|.|.|.:
Zfish  1355 TDSADEYDSS 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	21/100 (21%)
		MAM	288..447	CDD:99706	21/97 (22%)
		MAM	505..691	CDD:279023	34/215 (16%)
		MAM	505..689	CDD:99706	32/197 (16%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	114/316 (36%)
		TyrKc	1193..1460	CDD:197581	112/307 (36%)
mst1rb	XP_009304468.1	Sema_MET_like	41..506	CDD:200509	61/332 (18%)
		PSI	511..553	CDD:214655	7/45 (16%)
		IPT	553..658	CDD:214657	24/121 (20%)
		IPT_plexin_repeat2	660..748	CDD:238584	18/103 (17%)
		IPT_PCSR	751..844	CDD:238337	20/96 (21%)
		PTKc_Met_Ron	1068..1329	CDD:270649	111/272 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910