DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alk and mst1ra

DIOPT Version :9

Sequence 1:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster
Sequence 2:	XP_005166175.1	Gene:	mst1ra / 100002448	ZFINID:	ZDB-GENE-071218-2	Length:	1356	Species:	Danio rerio

Alignment Length:	1427	Identity:	303/1427 - (21%)
Similarity:	488/1427 - (34%)	Gaps:	507/1427 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 QPKRSNRK------NSISELYKLKKALNQADEPA----GGVTHGNF-----EGDPQPSS---ADP 250
            :|||..|.      ||:...:........||:..    ..:.:|.|     :|:|...|   |.|
Zfish   293 EPKRRRRSFRDVVYNSVQAAHFSTAGKELADDLGVRIDSPILYGVFAVTDQKGNPMRQSALCAFP 357

  Fly   251 LQEIKDRIRDTSPNANTYAPHTDATPSSEYEYELGVKCNFETPCSWTWGNYSDGFQVITGTELSK 315
            |..:...|.          ...||..||..|......|:|: ||.
Zfish   358 LDYVNSAIE----------KGVDACCSSLTEQISRGLCHFQ-PCE-------------------- 391

  Fly   316 RNLTGLLPGPAADSIDDANGHFLYARVNPSSRPLNLTSPEFSTTMEKCFLEVYMHQSDMSHGLSR 380
                 :.|...:||                     ||.....|.:.|.:..|......||:.|..
Zfish   392 -----MCPVENSDS---------------------LTCKTTPTMVSKPYYRVDFFNGQMSNVLFT 430

  Fly   381 VVVELLHTAESSWVPAEILGDNVRQWTRKVYRLGR-----VSRDFRIVFEVVPDLRVGQKG---- 436
            .:  |:.|.|:..| |.|..|:           ||     :||...:||.....:...||.
Zfish   431 SI--LVTTIETKTV-AHIGTDH-----------GRLLQIILSRSIPVVFANYSLVEDAQKVSRIA 481

  Fly   437 --HVALDNL------RMVNCFPEGTKSEKCSTSQVKCTSSKVPVCIHLPRI--CDITRDCDEAED 491
              |.:|::|      :::|..|.|   ..|| ..:.|::     |:..||.  |..   |.|...
Zfish   482 AIHSSLESLLFVVGNKLINVSPRG---PGCS-HFLNCSA-----CLAAPRFMGCGW---CGEVCS 534

  Fly   492 EQQSCDKIPYGGRCDFEEDWCGWRDSGKTTLT-------------------WSRHTGSSPTHDTG 537
            :|..|           |:.|.|  ||....:|                   |:..:.|.|.
Zfish   535 QQHQC-----------EDQWSG--DSCPPVITQFFPRTVPSNGTSELILCGWNFQSASRPA---- 582

  Fly   538 PDGDHTMQHLQNNTSGYYMLVNMNQH---MNNSEKNSIIGFASNAIMVSKTFNPPPSVHGNPDSP 599
                                :....|   :.||:...:....|::::|.:.......:|
Zfish   583 --------------------ITQESHQVRVGNSDCTVVPEKTSSSLLVCRIVGEESGLH------ 621

  Fly   600 YRNSCVVRFFIHQFGKNPGSINLSVVEMKEKENITTTLWWSTKNQGSDWMRAEYVLPNITSKYYL 664
                              .|:|:: :::.||:                          ..|.|::
Zfish   622 ------------------QSVNIT-IQVNEKK--------------------------AGSGYFI 641

  Fly   665 QFEARMGMRIYSDVAVDDFSLSPECFG-------LNIPEDHL--GGYNYWDVRQNLKSPTYKDFE 720
            ..:|  |::.:|.|..:...:||. ||       :.:...||  ||           |.|....:
Zfish   642 SGKA--GIQGFSFVTPEITDISPS-FGPKIGGTLITLSGKHLDAGG-----------SRTISLGD 692

  Fly   721 YTNYLELTTCDTRGMIGPSQAQCEAAYREQNKTHVLREVHVVEDQSSYKGMQKWKVPHEGHYTII 785
            ....:|..:.|...::      |.:   |..|..:..:|.||.|.|:....:.:........|.:
Zfish   693 RNCPVESVSSDGTSIV------CRS---EGVKDTLEVDVKVVIDGSTISSTKTFSYRVNPEVTGV 748

  Fly   786 AKGASGGLGSGGVGSSRGSVAVAILELHKNEELYFLVGQQGENACIKSMGVLKEAGCGTDHDLDL 850
                     :...|..|||..:.                .|:|....|..|:|..|...|.
Zfish   749 ---------NPNCGFRRGSKIII----------------TGQNLDSVSQAVIKYKGGYKDP---- 784

  Fly   851 AQYSFRSKQDMVKNIYIENGAGGGGGGSYVFLLNQAKNEAVPLLVAGGGGGLGIGQYIDEDFQHG 915
                            :|....|.|..:.:..::....|:..:|            .:|.|
Zfish   785 ----------------VETVCSGQGNPTQMECMSPVCEESTGIL------------SVDLD---- 817

  Fly   916 QKAKPLQAPE-SGQINGEPLNKKTAGPGGGWRAKEDQALSPTYGAALLQGGRGGHSCYVELADNG 979
             .||.||:.. :...||||:..:|          ||:.|.
Zfish   818 -GAKDLQSQTFTCHANGEPIPFET----------EDRVLE------------------------- 846

  Fly   980 TSVHRHGQGGFGGGGGGCNTGGGGGGYAGGDVYLTESNGEGGSSYISPSRSLREISEIHAGASSG 1044
                                                         :||.:.  |:|..|...:..
Zfish   847 ---------------------------------------------LSPGQD--EVSLHHKKLALV 864

  Fly  1045 PGAIIIIPAIEGCGCDYRCVALDEFRSKVRCICPDGWSLKRD--------NHTACEIREEAGKSS 1101
            .|.:.||..:.|..|:.:  .||   :::.|..|...::.|.        |....:|.....|:|
Zfish   865 SGCMEIIMTVNGVDCNAK--VLD---NEITCRIPKNLTIPRQGAPVKVLVNREEHDIGMVVMKNS 924

  Fly  1102 FQYLVSILMISLAVLFICIAALIFMLYNRYQRKKQSKKRHKMLVEQDLQLTRLR---NNIDDSNL 1163
             ..:|.:::..||.:.:. ||::::...:.::||::     .|||..|.:...|   .|.|.|..
Zfish   925 -NLIVGVVLGILAAVGVG-AAIVYVAMAQERKKKKA-----ALVEVRLSMHSNRTTAENYDRSPD 982

  Fly  1164 NNF------------NPNYGCDGILN-----GHIDVNSLPQVARD-------------------- 1191
            .::            :|.:|......     |.:|..:.|.:.|.
Zfish   983 GDYRRETVRPAGLSVSPFHGSGTTFTSLPYAGSMDSAAAPLMRRQVSMSALRPDLLEEVKNVLIS 1047

  Fly  1192 ----SLQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFN 1252
                .:|....:|||.||.||....  .|.|..|...|||:|......|:.|.||:|...|..|:
Zfish  1048 PDKIKIQHEQIIGKGHFGTVYHGYL--TDSDNKETHCAVKSLNRITDLEEVEQFLREGLFMKAFH 1110

  Fly  1253 HPNMVHLIGVCF--DRQPYYIVLELLAGGDLQKFLRENRNTPERPSLLTMKDLLFCALDVAKGCR 1315
            |.:::.|:|:..  |..| .::|..:..|||:.|:|    :|||..  |:|||:...|.||||..
Zfish  1111 HSHVLSLLGIVLPSDGLP-LVILPYMKHGDLRHFIR----SPERSP--TVKDLIGFGLQVAKGME 1168

  Fly  1316 YMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYY--RKGGKAMLPIKWMPPEAF 1378
            |:.:|:|:|||:|||||:|..   ...||:|||||:||:|..:||  :...||.||:|||..|:.
Zfish  1169 YLANKKFVHRDLAARNCMLDE---SFTVKVADFGMARDVYDKEYYSIQDSKKAKLPVKWMALESL 1230

  Fly  1379 LDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCW 1443
            ....||:|:||||:|:|:||:.:.|.||||......:...:::|.||..|..|..|::.|:..||
Zfish  1231 QTQKFTTKSDVWSYGVLMWELLTRGASPYPDVDPYDITPYLMQGRRLPQPQYCFDSLWSVLMQCW 1295

  Fly  1444 NPTPEDRPTFITLL------------EH-----LTACTQDASIMNAPLPNILGPTASERDDT 1488
            :|.||.||.|.||:            ||     :|....|   ...|.|::...|.:..|.:
Zfish  1296 HPEPEKRPGFTTLVQAVQDIHSSLDGEHYINLQITYVNLD---QPRPYPSLCPATPAHSDQS 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alk	NP_001261027.1	MAM	288..450	CDD:279023	34/178 (19%)
		MAM	288..447	CDD:99706	33/175 (19%)
		MAM	505..691	CDD:279023	27/207 (13%)
		MAM	505..689	CDD:99706	27/205 (13%)
		PTKc_ALK_LTK	1186..1462	CDD:270632	114/320 (36%)
		TyrKc	1193..1460	CDD:197581	112/287 (39%)
mst1ra	XP_005166175.1	Sema_MET_like	41..504	CDD:200509	56/281 (20%)
		PSI	507..>547	CDD:307546	14/61 (23%)
		IPT	550..654	CDD:326624	19/180 (11%)
		IPT_plexin_repeat2	655..740	CDD:238584	20/105 (19%)
		IPT	742..828	CDD:214657	23/147 (16%)
		PTKc_Met_Ron	1057..1318	CDD:270649	109/272 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1095
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810