DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLG and CG4793

DIOPT Version :9

Sequence 1:	NP_000292.1	Gene:	PLG / 5340	HGNCID:	9071	Length:	810	Species:	Homo sapiens
Sequence 2:	NP_723941.2	Gene:	CG4793 / 34941	FlyBaseID:	FBgn0028514	Length:	910	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	87/338 - (25%)
Similarity:	150/338 - (44%)	Gaps:	82/338 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   526 LEKNYCRNPDGDVGGPWCYTTNPRKLYDY---------CDVPQCAAPSFDCGKPQVE------PK 575
            :::|.||     :|     |...|.:.|:         |:..|...|..:..:..|:      |.
  Fly    30 VQRNRCR-----IG-----TETGRPIIDFRGLNNGNQGCESGQTCCPKTEILQYPVQADNQPLPT 84

Human   576 KCPGRV----VGGC------VAHPHSWPWQVSL---RTRFGMHFCGGTLISPEWVLTAA-HCLEK 626
            :| |.|    ||..      :|.....||.|:|   |:|..:.  ||:||:.:.|||:: ..||.
  Fly    85 EC-GHVNRIGVGFTITNARDIAQKGELPWMVALLDSRSRLPLG--GGSLITRDVVLTSSTKTLEV 146

Human   627 SPRPSSYKVILG------------AHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITD 679
               |..|.::..            ||::|.:...|:...:|   :|....:.|||.|:.|..:..
  Fly   147 ---PEKYLIVRAGEWDFESITEERAHEDVAIRKIVRHTNLS---VENGANNAALLFLARPLKLDH 205

Human   680 KVIPACLPSP--NYVVADRTECFITGWGETQGTFGA--GLLKEAQLPVIENKVCNR-------YE 733
            .:...|||.|  |::   ...|.::|||:......:  .:||:.:||:::..||..       .:
  Fly   206 HIGLICLPPPNRNFI---HNRCIVSGWGKKTALDNSYMNILKKIELPLVDRSVCQTKLQGPYGKD 267

Human   734 FLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVC---FEKDKYILQGVTSWGLGCARPNKPGVYVR 795
            |:   :.::.:|||. ..|.|:|:||.|.||.|   .:.::|.|.|:.::|.||..| .|..|..
  Fly   268 FI---LDNSLICAGG-EPGKDTCKGDGGAPLACPLQSDPNRYELLGIVNFGFGCGGP-LPAAYTD 327

Human   796 VSRFVTWIEGVMR 808
            ||:..:||:..::
  Fly   328 VSQIRSWIDNCIQ 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLG	NP_000292.1	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..145
		KR	183..263	CDD:214527
		KR	273..354	CDD:214527
		KR	375..456	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416
		KR	479..560	CDD:214527	8/42 (19%)
		Tryp_SPc	580..803	CDD:214473	71/262 (27%)
		Tryp_SPc	581..804	CDD:238113	72/262 (27%)
CG4793	NP_723941.2	Tryp_SPc	105..337	CDD:238113	70/247 (28%)
CG4793	NP_723941.2	Tryp_SPc	105..335	CDD:214473	68/245 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910