Protein Alignment PLD2 and SPO14

DIOPT Version :10

• Sequence 1: NP_002654.3
• Gene: PLD2 / 5338
• HGNCID: 9068
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_012956.3
• Gene: SPO14 / 853902
• SGDID: S000001739
• Length: 1683
• Species: Saccharomyces cerevisiae
• Alignment Length: 956
• Identity: 290/956 - (30%)
• Similarity: 458/956 - (47%)
• Gaps: 204/956 - (21%)

Human    61 PGVPVTAQVVGTE------RYTSGSKVGTCTLYSVRLTHG----DFSWTTKKKYRHFQELHRDLL 115
            |.:|.::.::...      .|:....    :|:.:.|.:|    ...|:..:.|:..:.||
Yeast   285 PSIPRSSSIISISSNVAEFMYSRNEN----SLFRIHLEYGIDEDRLKWSIIRSYKDIKSLH---- 341

Human   116 RHKVLMSLLPLARFAVAYSPARDAGNREMPSLP------------------RAGPEGSTRHAAS- 161
             ||:.:........:..||......:.::|..|                  :.....|..|.:.
Yeast   342 -HKLKIVAFQQLTISKLYSDNNRYHSLQLPHFPHYKEMVKERNVMEKKAENKPSSAASAPHTSEN 405

Human   162 ----------------------------KQKY------------------LENYLNRLLTMSFYR 180
                                        |.|:                  ||.|| |||.::...
Yeast   406 NNNDNGSNITSLETLSSSEISEFNIDNVKMKHLQDLIDEPDDFSQPIHLRLERYL-RLLNIALCL 469

Human   181 NYHA--MTEFLEVSQLSFI--PDLGRKGLEGMIRKRS----GGHRVPGLTCCGRDQVCYRWSKRW 237
            ..||  :.||.|:|.|..:  .:.|.:|.:|.:..||    .|.||..........:..|.:.:|
Yeast   470 RPHANRLFEFYELSPLGNLLSRESGFQGKQGYLVIRSTAKAQGWRVSHFGKHAFKDMIDRHTTKW 534

Human   238 LVVKDSFLLYMCLETGAISFVQLF-----------------------------DPGFEV------ 267
            .:|::|:|.|:. :..:.:.:.:|                             ||..|:
Yeast   535 FLVRNSYLTYVS-DLSSTTPLDVFLIDWKFKVRFSGNKNNILDNENEINWIIHDPNLEINDELEE 598

Human   268 ------------QVGKRSTEARHG--------VRIDTSHRSLILKCSSYRQARWWAQEITELAQG 312
                        :.||..|..:..        :.::.|.|.|.:.|.|....:.|...|.:::
Yeast   599 FGIENDANNILDKNGKSKTHQKKSNISSKLLLLTLENSERKLKIICKSESSLKQWMSSIIKMS-- 661

Human   313 PGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAH 377
            ....:.:.:|..|:||.|..:..::.|:|..||.::::|:|.|::.|:|.|||||||:||:||..
Yeast   662 TSTPWSKPNRFGSFAPVRTNSFCKFLVDGRDYFWSLSEALLMAKDVIYIHDWWLSPELYLRRPVK 726

Human   378 SDD-WRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQ----VT 437
            .:. :|:|.|||..||:|:::.|::::.|...:|.:|.::|.:::.|||||.::|.|:|    ..
Yeast   727 GNQGFRIDRMLKSCAEKGIKIFIVIYRNVGNIVGTDSLWTKHSMLNLHPNIHIIRSPNQWLQNTY 791

Human   438 LWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHN 502
            .||||||.:|:|:..||:||.||.|||:|...:.|.   |.:||...|      :.|
Yeast   792 FWAHHEKFVVIDETFAFIGGTDLCYGRYDTFEHVLR---DDAESLLDQ------NFP-------- 839

Human   503 QFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTK 567
                 ||||||....|:..||:|||...||:..|||||.||.::..|.|||||||||:||||:
Yeast   840 -----GKDYSNARIADFHDLDKPFESMYDRKVIPRMPWHDVQMMTLGEPARDLARHFVQRWNY-- 897

Human   568 TTKAKYKTPTYPYLLPKSTSTANQLPFTLP-------GGQCTTVQVLRSVDRWSAGTLEN--SIL 623
            ..:||..:...|.|.|.|..||.:|. :||       ...|.| |:|||...||.|..|.  ||.
Yeast   898 LLRAKRPSRLTPLLTPPSDLTAEELK-SLPMFEILREKSTCET-QILRSAGNWSLGLKETECSIQ 960

Human   624 NAYLHTIRESQHFLYIENQFFISCS--DGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPG 686
            ||||..|.:|:||:||||||||:.:  :|..||||:||.:||||:||:::...::.::|:||:||
Yeast   961 NAYLKLIEQSEHFIYIENQFFITSTVWNGTCVLNKIGDALVDRIVKANQEKKPWKAFILIPLMPG 1025

Human   687 FEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHP--V 749
            |:..:.|...:|::.|:.|.|:::.|||:|...:|| .:......||....||.......:.  :
Yeast  1026 FDSPVDTAEASSLRLIMQFQYQSISRGEHSTFSKLK-KLNIDPAQYIQFFSLRKWSTFAPNERLI 1089

Human   750 SELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALS 814
            :|.:|:|:|:||||||..||||||||:||.||.||||:|:||.||:...:.|||.:|.||:|...
Yeast  1090 TEQLYVHAKILIADDRRCIIGSANINERSQLGNRDSEVAILIRDTDLIKTKMNGDDYYAGKFPWE 1154

Human   815 LRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQI 860
            ||:......||.    |:||.: ..:..|:.::..|..|   ||::
Yeast  1155 LRQRLMREHLGC----DVDLVE-FVEKKFERFEKFAAKN---YEKL 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLD2	NP_002654.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		PLN02866	66..918	CDD:215467	288/951 (30%)
		Catalytic	441..788		156/359 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..497		5/19 (26%)
SPO14	NP_012956.3	PX_domain	300..>390	CDD:470617	14/98 (14%)
		PH_PLD	473..660	CDD:269956	34/187 (18%)
		PLN02866	<638..1165	CDD:215467	224/555 (40%)