Protein Alignment PLD2 and pld2

DIOPT Version :10

• Sequence 1: NP_002654.3
• Gene: PLD2 / 5338
• HGNCID: 9068
• Length: 933
• Species: Homo sapiens
• Sequence 2: XP_694649.4
• Gene: pld2 / 565743
• ZFINID: ZDB-GENE-060216-4
• Length: 948
• Species: Danio rerio
• Alignment Length: 945
• Identity: 561/945 - (59%)
• Similarity: 691/945 - (73%)
• Gaps: 45/945 - (4%)

Human    22 MESDEVDTLKEGEDPADRMHPFLAIYELQSLK---VHPLVFAPGVPVTAQVVGTERYTSGSKVGT 83
            ::|...|.||..|:.::: ..|:.::.|..||   :.||::  |.|:|.:|..|||||:.|||..
Zfish    16 VDSITEDQLKSIENNSEK-RDFIVVHHLADLKGGSISPLIY--GTPITCKVENTERYTTRSKVHV 77

Human    84 CTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAG-NREMPSL 147
            ||||:||||||:|:||.|:||:|||||||||.:|||::..|||.|||:.....  || ..|||:|
Zfish    78 CTLYTVRLTHGEFTWTVKRKYKHFQELHRDLYKHKVMLQFLPLGRFAIQRQQL--AGLTEEMPTL 140

Human   148 PRAGPEGS--TRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIR 210
                 .|:  .|..:||.||||.|||.||..:||:|||.|.:||.:|.||||.|||.|||||.|.
Zfish   141 -----HGTDRIRRTSSKPKYLEEYLNNLLENTFYKNYHGMMDFLAISPLSFIRDLGPKGLEGYIL 200

Human   211 KRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTE 275
            |||||||:.||.|.|..|.|:|||:|||||||||||||..:.|.:|||.||||..:|.||:..|:
Zfish   201 KRSGGHRIQGLNCIGHHQFCFRWSRRWLVVKDSFLLYMSRDPGIVSFVLLFDPELKVLVGRVYTD 265

Human   276 ARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVN 340
            .:||:.|:...|.|::||||||||:||:.||..|::  ..||.:|||.:.:|||||.||.:|:||
Zfish   266 IQHGICIENFDRKLVIKCSSYRQAQWWSHEIRSLSE--RCDFYKLHRFEGFAPPRPDTLTKWYVN 328

Human   341 GAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEV 405
            |.|||:.:|||:.:|:||||||||||||||:|||||....||||.:||||||:||:|.:||:|||
Zfish   329 GHGYFSDLADALEQAKEEIFITDWWLSPEVFLKRPATGTYWRLDKILKRKAEQGVKVCVLLYKEV 393

Human   406 ELALGINSGYSKRALMLLHPNIKVMRHPDQ----VTLWAHHEKLLVVDQVVAFLGGLDLAYGRWD 466
            |||||||||||||.||.||||||||||||.    |.|||||||::.:||.|||:||||||:||||
Zfish   394 ELALGINSGYSKRKLMSLHPNIKVMRHPDHVASVVVLWAHHEKMVAIDQSVAFVGGLDLAFGRWD 458

Human   467 DLHYRLTDLGD----SSESAASQPPTP------RPDSPATP------------DLSHNQFFWLGK 509
            |..|||:||..    |...|||:.|||      ..|..|.|            |||.|...||||
Zfish   459 DSDYRLSDLDSPKQPSPPEAASELPTPSLSQGDTVDGSAVPLTQPASECEDEVDLSCNALLWLGK 523

Human   510 DYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYK 574
            ||||.|.:||.|||:||:|.:||...||:||||:|...||..||||||||||||||||..|.|||
Zfish   524 DYSNFIKRDWTQLDQPFQDNVDRTQVPRIPWRDLGAAHHGKAARDLARHFIQRWNFTKIFKNKYK 588

Human   575 TPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYI 639
            ...||||||||..|::.|||::||....:||||||||||||||.|:||||||:|.|..|||::|:
Zfish   589 DDFYPYLLPKSHCTSDTLPFSIPGATKASVQVLRSVDRWSAGTCEHSILNAYVHVIENSQHYIYL 653

Human   640 ENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILH 704
            ||||||||::.:.|.|.:||.||.|||:||.:|..:||:|::|||||||||||.||||:||||||
Zfish   654 ENQFFISCAEEKNVQNTIGDAIVKRILRAHSEGKKFRVFVVIPLLPGFEGDISQGGGNAIQAILH 718

Human   705 FTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVII 769
            |||||:.|||:|||.|||..|...|..|.|:||||||.:||..||:||||:|||.||||||..||
Zfish   719 FTYRTINRGEHSILSRLKEQMQDKWTQYFSLCGLRTHSQLGSSPVTELIYVHSKALIADDRCYII 783

Human   770 GSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDL 834
            |||||||||:||.||||||||:||.|...|:|:|.|||||..||:|||.||.|:|||.:.|.||:
Zfish   784 GSANINDRSMLGTRDSELAVLVEDEERISSVMDGEEYQAGPLALALRKECFSVLLGAKSDPSLDI 848

Human   835 RDPICDDFF-QLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQ 898
            .|||.|.|| .:|..:|::||.|||::|||||.::.|:||.|.|:...|.|:...|..||.||..
Zfish   849 DDPISDHFFNDVWNKVAQTNAIIYEKVFRCLPLDSIRNLRELMEHKNSENLSLTDPEKAREELQA 913

Human   899 VQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT 933
            ::|.||||||.||.:|:|||||.||||::|:||||
Zfish   914 IRGILVHFPLHFLCEENLLPPLKSKEGIVPIEVWT 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLD2	NP_002654.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		4/11 (36%)
		PLN02866	66..918	CDD:215467	535/881 (61%)
		Catalytic	441..788		230/368 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..497		9/29 (31%)
pld2	XP_694649.4	PLN02866	81..939	CDD:215467	527/866 (61%)