DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLD2 and Pld

DIOPT Version :9

Sequence 1:NP_002654.3 Gene:PLD2 / 5338 HGNCID:9068 Length:933 Species:Homo sapiens
Sequence 2:NP_001137610.1 Gene:Pld / 35554 FlyBaseID:FBgn0286511 Length:1364 Species:Drosophila melanogaster


Alignment Length:1212 Identity:456/1212 - (37%)
Similarity:609/1212 - (50%) Gaps:291/1212 - (24%)


- Green bases have known domain annotations that are detailed below.


Human     3 ATPES---LFPTGDELDSSQLQMESDEVDTLKEGEDPADR-----MH--PFLAIYELQSLKVHPL 57
            |.|:|   |...||:    .:.:|..|.|..:|..|..:.     .|  ||.:||. .|:|.:..
  Fly   163 AFPDSVTILSNVGDK----PVLVERKETDDDEEEFDDEENNSVVLRHEIPFTSIYG-PSVKFNSF 222

Human    58 ---VFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELH-------- 111
               ||.||..:..::|.|||..:...:.. .||::.||||.|.||.|::|:||..||        
  Fly   223 QRKVFIPGREIHVRIVDTERSVTTHLLNP-NLYTIELTHGPFKWTIKRRYKHFNSLHQQLSFFRT 286

Human   112 -------------------------------RDLLRH-KVLMSLLPL-------------ARFAV 131
                                           :||..| ||..:..||             |..|:
  Fly   287 SLNIPFPSRSHKEKRTTLKATAREMADESTLKDLPSHTKVKQTSTPLRAEGRSSKIAGSNANNAM 351

Human   132 A-YSPARD---AG--------------NREMPSLPRAGPEG--STRHAASKQKYLENYLNRLLTM 176
            | .||...   ||              .|::|..|.. ||.  :..:.:.:.|.||:||..||.:
  Fly   352 AMISPNHSSILAGLTPRRIQKKRKKKKKRKLPRFPNR-PESLVTVENLSVRIKQLEDYLYNLLNI 415

Human   177 SFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPG-----------LTCCGR---- 226
            |.||::|....|:|||.:||:|.:|.||.||:|.||:|..| ||           ..||.|    
  Fly   416 SLYRSHHETLNFVEVSNVSFVPGMGIKGKEGVILKRTGSTR-PGQAGCNFFGCFQKNCCVRCNYF 479

Human   227 --DQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSL 289
              |.||..|..||..||::...|:....|:|..|.|||.||:|..|...|..|.|:::.|::|.:
  Fly   480 CSDVVCGTWRNRWFFVKETCFGYIRPTDGSIRAVILFDQGFDVSTGIYQTGMRKGLQVLTNNRHI 544

Human   290 ILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILR 354
            :|||.:.|:.:.|.|.:...|....|||...:.|.|:||.|..|.|.|:|:||.|.:||||.:..
  Fly   545 VLKCWTRRKCKEWMQYLKNTANSYARDFTLPNPHMSFAPMRANTHATWYVDGAQYMSAVADGLEA 609

Human   355 AQEEIFITDWWLSPEVYLKRPA-HSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKR 418
            |.|||:|.|||||||:|:|||| ..|.||||.:|.||||:||||.:||:||||:||||||.|||.
  Fly   610 ALEEIYIADWWLSPEIYMKRPALDGDYWRLDKILLRKAEQGVRVFVLLYKEVEMALGINSYYSKS 674

Human   419 ALMLLHPNIKVMRHPDQ----VTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSS 479
            .| ..|.|||||||||.    :.|||||||::|:||..||:||:||.||||||.|:||||||..|
  Fly   675 TL-AKHENIKVMRHPDHARGGILLWAHHEKIVVIDQTYAFMGGIDLCYGRWDDHHHRLTDLGSIS 738

Human   480 -------------------------------------ESAASQPPTPRPDSPAT----------- 496
                                                 .||..:||:|.||.|.|           
  Fly   739 TSSFSGSTRRTPSLYFTKDDTDSAFGSRKSSRNAHYDTSAKERPPSPPPDEPNTSIELKTLKPGD 803

Human   497 -----------------------------------------------------PDLSH------- 501
                                                                 .|..|       
  Fly   804 RLLIPSTLVSSPGETPAESGIALEGMKLNTPEMERKNVLDRLKNNAMKGARMGKDFMHRLTATET 868

Human   502 -----------------------------------------NQF-----FWLGKDYSNLITKDWV 520
                                                     ::|     :|.||||||.|.|||:
  Fly   869 EEKSAEVYTIESEEATDHEVNLNMASGGQEVAITTSSTQILSEFCGQAKYWFGKDYSNFILKDWM 933

Human   521 QLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKS 585
            .|:.||.|.|||.|||||||.|||:.|.|..|||:|||||||||..|..|.:..| .:|||:|||
  Fly   934 NLNSPFVDIIDRTTTPRMPWHDVGLCVVGTSARDVARHFIQRWNAMKLEKLRDNT-RFPYLMPKS 997

Human   586 TSTANQLP-FTLPGGQCTTVQVLRSVDRWSAG-----TLENSILNAYLHTIRESQHFLYIENQFF 644
            .......| ......|..|.|:||||..||.|     .:|.||.:||:.||.::||::|||||||
  Fly   998 YHQVRLNPNIQQNRQQRVTCQLLRSVSAWSCGFIEADLVEQSIHDAYIQTITKAQHYVYIENQFF 1062

Human   645 ISCSDG-------RTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAI 702
            |:...|       ..|.|::|:.:..||::|||:...:||||::|||||||||:....|.:::||
  Fly  1063 ITMQLGMGVPGAYNNVRNQIGETLFKRIVRAHKERKPFRVYVIMPLLPGFEGDVGGSTGIAVRAI 1127

Human   703 LHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTV 767
            .|:.|.::.||..|||.||:.|......:|||...||.|..|...|::||||:|||:||||||.|
  Fly  1128 THWNYASISRGRTSILTRLQEAGIANPENYISFHSLRNHSFLNNTPITELIYVHSKLLIADDRVV 1192

Human   768 IIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILG-----AN 827
            |.|||||||||::||||||:|.::.|.|.|...|||.:|.:|.||..|||:.|...||     .:
  Fly  1193 ICGSANINDRSMIGKRDSEIAAILMDEEFEDGRMNGKKYPSGVFAGRLRKYLFKEHLGLLESEGS 1257

Human   828 TRPDLDLRDPICDDFFQ-LWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPL 891
            :|.|||:.||:|:.|:. .|:.::..|..||:::|:|:|::..::..:||:|....|||..:|.|
  Fly  1258 SRSDLDINDPVCEKFWHGTWRRISMQNTEIYDEVFKCIPTDFVKTFASLRKYQEEPPLAKTAPDL 1322

Human   892 ARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT 933
            |.:....:||:||..||:||..|.|.||..||||:||..|||
  Fly  1323 AANRANDIQGYLVDLPLEFLNKEVLTPPGTSKEGLIPTSVWT 1364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLD2NP_002654.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 10/33 (30%)
PX_domain 62..192 CDD:295365 52/202 (26%)
PLN02866 66..918 CDD:215467 423/1119 (38%)
PH_PLD 180..309 CDD:269956 54/145 (37%)
PLDc_SF 335..475 CDD:301585 93/144 (65%)
Catalytic 441..788 191/513 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..497 10/120 (8%)
PLDc_vPLD2_2 614..795 CDD:197303 94/192 (49%)
PldNP_001137610.1 PX_PLD 230..431 CDD:132805 52/202 (26%)
PH_PLD 419..564 CDD:269956 54/145 (37%)
PLDc_vPLD1_2_yPLD_like_1 590..734 CDD:197236 93/144 (65%)
PLDc_vPLD1_2_yPLD_like_2 1032..1220 CDD:197239 92/187 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152692
Domainoid 1 1.000 223 1.000 Domainoid score I2588
eggNOG 1 0.900 - - E1_COG1502
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 788 1.000 Inparanoid score I523
Isobase 1 0.950 - 0 Normalized mean entropy S3079
OMA 1 1.010 - - QHG58673
OrthoDB 1 1.010 - - D330134at33208
OrthoFinder 1 1.000 - - FOG0001475
OrthoInspector 1 1.000 - - otm41338
orthoMCL 1 0.900 - - OOG6_100567
Panther 1 1.100 - - O PTHR18896
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2299
SonicParanoid 1 1.000 - - X1041
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.750

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