Protein Alignment PLD2 and pld1

DIOPT Version :10

• Sequence 1: NP_002654.3
• Gene: PLD2 / 5338
• HGNCID: 9068
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_592986.1
• Gene: pld1 / 2542065
• PomBaseID: SPAC2F7.16C
• Length: 1369
• Species: Schizosaccharomyces pombe
• Alignment Length: 1293
• Identity: 350/1293 - (27%)
• Similarity: 517/1293 - (39%)
• Gaps: 397/1293 - (30%)

Human     4 TPESLFPTGDELDSSQLQMESDEVD-----TLKEGEDPADRMHPFL--AIYELQSLKVHPL---- 57
            |||.:..|.::.:.....:|.||.|     |.|...:.|.:|...|  ::.:.:.....|:
pombe   109 TPEFITQTMEDENVEVPPLERDERDAAAAHTSKANRNSARQMWAQLMASVRKFKREDEKPILKEN 173

Human    58 -----VFAPGVPVTAQVVGTERYTSGSKVGTCTL------------------------YSVRLTH 93
                 :|..|:|.:..:.   ::....|.|...|                        :::::.:
pombe   174 LPAINLFEAGIPASLPIA---KHFIRDKSGQPVLPIITDLIKVSVLDVEPKHNRIHSTFTIQVEY 235

Human    94 GD----FSWTTKKKYRHFQELHRDLL----RHKVLMSLLPLARF---------------AVAYSP 135
            |.    ..|...::.|.|..||...|    :|:.....:.|.:|               .:.||.
pombe   236 GTGPHAIRWLIYRQLRDFINLHSHFLFFEFQHRFSGRRMKLPKFPKEVLPYLVKLRGYQKILYSN 300

Human   136 ARDAGNREMPSLPRAGPE----------GSTRHAASKQKYLEN-----------YLNRLL-TMSF 178
            ..|....|..|:.....|          |..|||.:.:|...|           ||..:: .:.|
pombe   301 PSDQLIDETHSISDISWESHSQDGDRTTGQPRHANNGRKKHGNFWTIQGNTLGVYLQEMIHNLQF 365

Human   179 YRNYHAMTEFLEVSQLS-FIPDLGR-KGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVK 241
            :...:.:..|||.|.|. ::...|. .|.||....:........:.||....:..|....|::|.
pombe   366 FPEVNVLYSFLEFSSLGLYLAGAGTFHGKEGFATLKRNYSPTQYMLCCNTTMMKTRSQPFWIIVS 430

Human   242 DSFLLYMCLETGAISF----VQLFDPGFEVQVGKRSTEARH----GVRIDTSHRSLILKCS---- 294
            :|.:: :|  ...:|.    |.::|..||:.  :::....|    ..:|..||.|..:|..
pombe   431 ESCII-LC--DNMLSMQPADVFIWDVDFEIT--RKNFRKAHSKDTNEKIRLSHHSFKIKNRQKVM 490

Human   295 --SYRQARWWAQEI--TELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRA 355
              |.|..||..|.|  .::|||. ..:.::||.||:||.|.....:|.|:...:...|:.||..|
pombe   491 KLSVRSGRWLQQFINSVQVAQGL-TAWCEIHRFDSFAPVRTNVAVQWMVDARDHMWNVSRAIKNA 554

Human   356 QEEIFITDWWLSPEVYLKRP---AHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSK 417
            :..|.|..||||||:.::||   ||.  ||:|.:|..||.|||.|.|::::.::..:.|:|.::|
pombe   555 KRCIMIHGWWLSPELQMRRPYSMAHK--WRIDRILNEKAHEGVMVYIMIYRNIDATIPIDSFHTK 617

Human   418 RALMLLHPNIKVMRHP----DQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDS 478
            ..|..|||||.|:|.|    .....|||||||:|||..:.|:||:||.:||:|...:.|.|
pombe   618 EHLQSLHPNIYVIRSPSHFRQNALFWAHHEKLVVVDDAITFIGGIDLCFGRYDTPQHILYD---- 678

Human   479 SESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDV 543
                         |.|........:..|.||||||....|:..|..|::|..||...|||.|.||
pombe   679 -------------DKPVADKTGLCEQTWRGKDYSNARVHDFFDLTEPYKDMYDRLAVPRMGWHDV 730

Human   544 GVVVHGLPARDLARHFIQRWNF-TKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVL 607
            .:.:.|.||||.||||:||||: .:..|...||   |.|:|....|.:||..:...|.| .||||
pombe   731 SMCIIGQPARDAARHFVQRWNYLIQCKKPARKT---PLLIPPPDFTTDQLTDSQLTGTC-EVQVL 791

Human   608 RSVDRWSAG---TLENSILNAYLHTIRESQHFLYIENQFFISCS--DGRTVLNKVGDEIVDRILK 667
            ||...||.|   |:|.||.|||:..|.:|:||:|||||||::.:  :|.|:.|:|||.:|:||::
pombe   792 RSAGLWSLGLVDTVEQSIQNAYVTCIEKSEHFIYIENQFFVTSTTCEGTTIENRVGDALVERIIR 856

Human   668 AHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDY 732
            |||....:|..:::||||||||.|....|.|::.|:...||::|.||:||..||. |.|.....|
pombe   857 AHKNNEKWRGVIMIPLLPGFEGQIDLQEGGSLRLIVECQYRSICHGEHSIFGRLN-AKGIDGSKY 920

Human   733 ISICGLRTHGELG-GHP-VSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTE 795
            :...|||....|| .|. |:|:||:|:|:||||||..:|||||||:|||||.||||:|.:|.||.
pombe   921 LRFYGLRGWAHLGENHELVTEMIYVHAKILIADDRVAVIGSANINERSLLGNRDSEIAAVIRDTL 985

Human   796 TEPSLMNGAEYQAGRFALSLRKHCFGVILGA---------------------------------- 826
            |..|.|:|..|:.|:||.:|||......||.
pombe   986 TIDSKMDGKPYKVGKFAHTLRKRLMREHLGLETDVLEQREYNMDGLDRDTEWKRVEVWTPDEGNA 1050

Human   827 ---------------------NTRPD-----------LDLR------------------------ 835
                                 .|.||           ||.|
pombe  1051 INGSAYTAEELKMKYRSQSQFTTTPDILRKAEKSMKKLDQRVSLIPSSIEFNIKTQKDKVEFEKN 1115

Human   836 ----------------------------------------------------------------- 835
                                                                             
pombe  1116 YEKSKKGPDVIANALVGGIPLSLKTKEDSLYELSKFSQCGEDQRPMVLKDPDHLVPEPSRPHCGN 1180

Human   836 ------------------------------DPICDDFFQ-LWQDMAESNANIYEQIFRCLPSNAT 869
                                          ||:||:||: :|..:|.:|..||..||||:|.:..
pombe  1181 GLVFYDDIPLLEVNPISGETIPKFDASSFEDPVCDEFFEDIWSKVASNNTTIYRHIFRCVPDDEM 1245

Human   870 RSLRTLREYVAV-------------EPLATVSPPLARSE-------------------------- 895
            .:..:..|:...             |.|:.:.....:||
pombe  1246 LTWESYNEWKKYGKRFKEEQARWRQEELSNLHETHEKSENDPKNPKAGSQGSGNTSASEDSKTEK 1310

Human   896 --------------------LTQVQGHLVHFPLKFLEDESLLPP-LGSKEGMIPLEVW 932
                                |..::|.||..|||::..||.... |.|.:.:.|||::
pombe  1311 PKTRTNNGLQVPDKRVVYDLLRGIRGQLVELPLKWMSTESNARNWLSSIDKIPPLEIY 1368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLD2	NP_002654.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		10/34 (29%)
		PLN02866	66..918	CDD:215467	328/1198 (27%)
		Catalytic	441..788		161/354 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..497		2/19 (11%)
pld1	NP_592986.1	PX	215..377	CDD:214610	26/161 (16%)
		PLN02866	355..1143	CDD:215467	273/817 (33%)