Protein Alignment PLD2 and pld-1

DIOPT Version :10

• Sequence 1: NP_002654.3
• Gene: PLD2 / 5338
• HGNCID: 9068
• Length: 933
• Species: Homo sapiens
• Sequence 2: NP_494939.1
• Gene: pld-1 / 173876
• WormBaseID: WBGene00004040
• Length: 1427
• Species: Caenorhabditis elegans
• Alignment Length: 1359
• Identity: 432/1359 - (31%)
• Similarity: 578/1359 - (42%)
• Gaps: 448/1359 - (32%)

Human     3 ATPESLFPTGDELDSSQLQMESDEVD-------TLKE---GEDPADRMHPFLAIYELQSLKVHPL 57
            ::|:|| ..||..|||    :.||:.       .|::   |......:.|:::||:.|.......
 Worm    89 SSPQSL-DYGDSDDSS----DDDEIQYCDCVAAALQQSLPGTPGRKGIIPYMSIYDTQQQARRRG 148

Human    58 VFAPGVPVTAQVVGTERYTS-GSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLM 121
            .:.|||||.|::|..||.|. |.......||::.|.||.|.|:..:.|:.|..|:..|:.|:...
 Worm   149 YWIPGVPVNAKIVKVERNTDRGIHFINTLLYTIELEHGQFRWSVIRNYKDFTLLNNRLMAHRARE 213

Human   122 SLL-PLAR--------------------------------------------------------- 128
            ..: |:.|
 Worm   214 QFMAPIKRTQERFDNYLEHMGIDIISDHKPECPYSNQSSKRKRHPKLQVLKRDSDGIEESKNTSA 278

Human   129 -FAVAYSP--ARDAGNREM-------------------------------------PSLPR--AG 151
             .|...||  ..||..:|:                                     .:|||  ..
 Worm   279 PLASVESPGEVEDAFKKEVHMQQAVQSGILDETVNEANTSEGTPKRQRRQQRKKDRHTLPRFPMM 343

Human   152 PEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGH 216
            |:....:...:::.|||:|..:|.:...||:|...||||||:.||:.:||.|..||.::||.||.
 Worm   344 PDSMVTNLEHRKELLENWLQMVLHIPINRNHHETAEFLEVSRYSFVNELGGKHTEGFVKKRPGGS 408

Human   217 RVPGLTCCGRDQVCYR----WSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEA- 276
            ||    ..|..|.|.|    ||||||:|:|||:.||...|..|..|.|.|..|:|..|.:.||.
 Worm   409 RV----FLGWKQCCVRYLLPWSKRWLMVRDSFVAYMDHRTEQIRMVLLMDRDFKVAAGGKETEGI 469

Human   277 RHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNG 341
            ..|:.|..|...|.|||...:....|...|.:...|.|..:||.||..|..|.|....|:|||:.
 Worm   470 PTGLIITNSQHELHLKCRRLQDTATWKYIIEQAMGGIGNTWLQPHRFSSSFPVRENCHAKWFVDA 534

Human   342 AGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPA-HSDDWRLDIMLKRKAEEGVRVSILLFKEV 405
            ..|....||.:..|:|||:|||||||||:|:|||| ..:.||||.:||||||:||::.|||:||:
 Worm   535 KTYMEYAADMMELAREEIYITDWWLSPEIYMKRPALEGNYWRLDEILKRKAEQGVKIFILLYKEM 599

Human   406 ELALGINSGYSKRALMLLHPNIKVMRHPDQ-----VTLWAHHEKLLVVDQVVAFLGGLDLAYGRW 465
            |:|||:||.||||.|..||.|||||||||.     ...||||||||::||:::|:||:||.:|||
 Worm   600 EMALGLNSIYSKRTLQGLHENIKVMRHPDHYPSTGTFFWAHHEKLLIIDQLISFVGGVDLCFGRW 664

Human   466 DDLHYRLTDLGDSSESAASQ----------------------------PPTPRPD---------- 492
            ||..:.|||||....|.|.|                            ..|||.:
 Worm   665 DDHRHLLTDLGSVQYSGAHQVATNMASGLRSLMTAPLTLSPLGLEEHEKVTPRNENGGKNGSVKR 729

Human   493 ----------------------------------------------------------------- 492
                                                                             
 Worm   730 VAVEEINEVDEPKEVTGRTQETELTDNEDISEDSDVKKIMEETIFTDKETGGVVVRTLNRFPVDE 794

Human   493 -----SPATP------------------------------------------------------- 497
                 |||.|
 Worm   795 AIRHSSPADPQKNWKETKTTVVESTSTSGGVTSKTTTTTTTTRVVKDNTLEKEKNKKELRRAVTS 859

Human   498 ----------------------------------------------------------------- 497
                                                                             
 Worm   860 LERQRKHVPREILDKAGPAPSMIEKAAKSGMDFASAAEKYKEYVASGAVQKEKHRAQTPPNRRKA 924

Human   498 --------------------------------------------------------DLSHNQFFW 506
                                                                    ::......|
 Worm   925 KKDSRITRAVGAVGNWKSNRAKRKWKQMLESDEATMGYELDWLRLREMDEKGDGDDEIDGGAKLW 989

Human   507 LGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKA 571
            .||||.|.|.||:|::|.||.|||||.:||||||.|:..|..|.||||||||||||||.|||.|.
 Worm   990 YGKDYVNYIAKDFVEVDMPFHDFIDRGSTPRMPWHDIHSVTFGAPARDLARHFIQRWNATKTEKL 1054

Human   572 KYKTPTYPYLLPKS---------TSTANQLPFTLPGGQCTTVQVLRSVDRWSA--GTLENSILNA 625
            | ....||||||||         ..|||       ..:...||||||:..||.  ...|:||..|
 Worm  1055 K-DDKNYPYLLPKSYENVRVPRVFKTAN-------ASEMVNVQVLRSLSNWSGLINQTEDSIQMA 1111

Human   626 YLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGD 690
            ||..|..|:|::|||||||:|..:...|.|:|...|.:||::|:|:...||||:::|||||||||
 Worm  1112 YLSLIANSKHYIYIENQFFVSMIESNDVTNEVCKVIYNRIVRAYKEKDNYRVYIMIPLLPGFEGD 1176

Human   691 ISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYI 755
            :...||:|:||:||:||::|.:|..|::.||||.|...:: ||.:..|||:.:||...||||:||
 Worm  1177 VGAPGGSSLQAVLHWTYQSLSQGPNSLIQRLKAVMPDPFK-YIHVGSLRTYDQLGQKLVSELVYI 1240

Human   756 HSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCF 820
            |.|:||.||..||||||||||||..|.||||:..:..|...|.|:|:|..::|||||.|||..|.
 Worm  1241 HCKLLIVDDEHVIIGSANINDRSQCGNRDSEVCCVYTDVVKERSVMDGKPFEAGRFAKSLRMQCM 1305

Human   821 GVILGANTRPD----------LDLRDPICDDFF-QLWQDMAESNANIYEQIFRCLPSNATRSLRT 874
            ...||  ..||          :...||:.|.|| .:||..|:||..|||::||..|::...:...
 Worm  1306 REHLG--LLPDSRRKAKFPYAVSCDDPVADSFFVDVWQSTAKSNGQIYEEVFRSYPTDFVETFEE 1368

Human   875 LREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT 933
            .:::.:..|::..||..|...:..::|.||.|||.||....|.|.:.||||::|..|:|
 Worm  1369 FQKWTSQIPMSEYSPQQAEERVRDLKGVLVDFPLNFLCKAVLTPGITSKEGLVPSAVFT 1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLD2	NP_002654.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		11/40 (28%)
		PLN02866	66..918	CDD:215467	403/1269 (32%)
		Catalytic	441..788		189/641 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..497		9/127 (7%)
pld-1	NP_494939.1	PLN02866	158..>681	CDD:215467	190/526 (36%)
		PLDc_vPLD1_2_yPLD_like_1	528..674	CDD:197236	86/145 (59%)
		PLN02866	<988..1426	CDD:215467	209/448 (47%)
		PLDc_vPLD1_2_yPLD_like_2	1101..1278	CDD:197239	91/177 (51%)