Protein Alignment PLD2 and pld2

DIOPT Version :10

• Sequence 1: NP_002654.3
• Gene: PLD2 / 5338
• HGNCID: 9068
• Length: 933
• Species: Homo sapiens
• Sequence 2: XP_031753569.1
• Gene: pld2 / 100216200
• XenbaseID: XB-GENE-5998608
• Length: 939
• Species: Xenopus tropicalis
• Alignment Length: 939
• Identity: 583/939 - (62%)
• Similarity: 708/939 - (75%)
• Gaps: 21/939 - (2%)

Human     7 SLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVG 71
            :|.|  |.||...|..:.||||...:.|:......||||||:::.||....||..||||||:|..
 Frog    10 NLLP--DSLDPGALVNDIDEVDFSGDEEEDGFPRSPFLAIYDMKPLKHERSVFMKGVPVTARVSD 72

Human    72 TERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLL---PLARFAVAY 133
            |||||.|:||...|||::.||||.|:||.|||::|||||||||||||:.:|.|   ||:||.|..
 Frog    73 TERYTRGTKVRHSTLYTIILTHGPFTWTIKKKFKHFQELHRDLLRHKLFISFLPFNPLSRFHVTR 137

Human   134 SPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIP 198
            |.. :..:.||||||.|..|.|.| .|||:.||.||||.||..|||||||||.|||:|||||||.
 Frog   138 SRV-ETTSSEMPSLPHASGEASQR-MASKKAYLNNYLNVLLEKSFYRNYHAMREFLDVSQLSFIA 200

Human   199 DLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDP 263
            |||.|||||.|:|||||||:.||.|.|..|:||||||||||||||||||:..:||.||||.||||
 Frog   201 DLGPKGLEGFIQKRSGGHRIQGLNCFGHHQICYRWSKRWLVVKDSFLLYLKPDTGEISFVLLFDP 265

Human   264 GFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAP 328
            ||.:.:|||:||.::||:|....|:|.|||:.||||.||.|:|..||:..|:|||.|||.|.:||
 Frog   266 GFSIDIGKRTTETKYGVKIQNFTRALTLKCNGYRQASWWGQQIRRLAEDHGKDFLSLHRFDCFAP 330

Human   329 PRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEE 393
            .|..|..:|||||:.||||||||:::||||||||||||||||:||||||:|||||||:||||||.
 Frog   331 VREKTQVKWFVNGSTYFAAVADALMQAQEEIFITDWWLSPEVHLKRPAHTDDWRLDIILKRKAEA 395

Human   394 GVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVT----LWAHHEKLLVVDQVVAF 454
            ||||.:||||||::||||||.||||.|||||||||||||||.|:    |||||||::.:||.|.|
 Frog   396 GVRVCVLLFKEVQMALGINSDYSKRVLMLLHPNIKVMRHPDHVSSVVFLWAHHEKMVAIDQSVVF 460

Human   455 LGGLDLAYGRWDDLHYRLTDLG---DSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLIT 516
            |||||||||||||..|||||:|   ...:|.:.:......:...:|:::.   :||||||||.|.
 Frog   461 LGGLDLAYGRWDDHEYRLTDVGPMEQQQQSRSMEGDITMNEVEQSPNVTQ---YWLGKDYSNSIY 522

Human   517 KDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYL 581
            |||||||:||||||||...|||||||||.||||..|||::||||||||:|||  .|||..|||||
 Frog   523 KDWVQLDKPFEDFIDRMKNPRMPWRDVGAVVHGKAARDVSRHFIQRWNYTKT--MKYKAATYPYL 585

Human   582 LPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFIS 646
            ||||.|||::..:|:||.....||||||||.||||..|.|||||||..|..|||::|:||||||:
 Frog   586 LPKSLSTADRQHYTVPGCHTAAVQVLRSVDWWSAGCTEYSILNAYLDCIENSQHYVYLENQFFIT 650

Human   647 CSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLC 711
            |:||||:.|.:||.||.||.:||.....:||::::||||||:|:|..|||.|||||||:||.|:|
 Frog   651 CADGRTIFNNIGDAIVKRIQQAHSAKANFRVFIVIPLLPGFQGNIEVGGGYSIQAILHYTYSTIC 715

Human   712 RGEYSILHRLKAAMGTAWRDYISICGLRTHGEL-GGHPVSELIYIHSKVLIADDRTVIIGSANIN 775
            ||:.||:.|||..||..|..|:|:|||||||:: .|..|:||:|||||:||.|||.|||||||||
 Frog   716 RGDNSIISRLKETMGEDWTKYLSVCGLRTHGDMPDGSLVTELVYIHSKMLIVDDRRVIIGSANIN 780

Human   776 DRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICD 840
            |||:||.||||||||:||.|...|:|:|..||||:||||||..||..||||...|.:|:.||:.|
 Frog   781 DRSMLGSRDSELAVLVEDMEFVSSVMDGEPYQAGKFALSLRMDCFNTILGARASPHIDVSDPVTD 845

Human   841 DFF-QLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLV 904
            .|| ::|:..|.:|..:|:|:|||||::|..|.|||:||.||:.||.::|.|||.:||.::||||
 Frog   846 HFFNEVWKQTAFNNTYVYDQMFRCLPADAVTSNRTLQEYTAVKNLAALNPGLAREQLTGIRGHLV 910

Human   905 HFPLKFLEDESLLPPLGSKEGMIPLEVWT 933
            ..||:||..|:|||||.||||:|..:|||
 Frog   911 ECPLQFLSGENLLPPLSSKEGLISSQVWT 939

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLD2	NP_002654.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		10/26 (38%)
		PLN02866	66..918	CDD:215467	546/863 (63%)
		Catalytic	441..788		218/350 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..497		1/19 (5%)
pld2	XP_031753569.1	PLN02866	88..938	CDD:215467	542/856 (63%)