Protein Alignment TPCN1 and tpcn1

DIOPT Version :10

• Sequence 1: NP_001137291.1
• Gene: TPCN1 / 53373
• HGNCID: 18182
• Length: 888
• Species: Homo sapiens
• Sequence 2: XP_695923.4
• Gene: tpcn1 / 567534
• ZFINID: ZDB-GENE-060526-199
• Length: 811
• Species: Danio rerio
• Alignment Length: 812
• Identity: 571/812 - (70%)
• Similarity: 673/812 - (82%)
• Gaps: 22/812 - (2%)

Human    71 ENMAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSPSSP 135
            :||...|..|.|:.::   .....:.|.:|.|..::         :::...|:..:....:.:|.
Zfish     8 DNMDTGLTQDRPVQMS---SFYKEIEPVDGAGNHDV---------VNNVTIPASGASDPRAQNSL 60

Human   136 AHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLCEAP 200
            ..:||||:||||||||||||||||||||:.|.||:||||||:||||::||.||:||:||||.|||
Zfish    61 QQSWEMNFQEAAIYLQEGENNDKFFTHPRSAHALSAYLFAHSHLFYVVELLTAVLLMLLSLSEAP 125

Human   201 AVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVR 265
            |||.|||.:||||||||.||::|.|||||||||||.||||||||||||||||.:||:||||||||
Zfish   126 AVPFLRLDVYVHATLELLALVMVAFELCMKLRWLGFHTFIRHKRTMVKTSVLFIQFIEAIVVLVR 190

Human   266 QMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPNP 330
            |.||:|||||||.||||||||||.|||||||||||||||:||||||||||:|||||||.|||.|.
Zfish   191 QTSHLRVTRALRPIFLVDCRYCGAVRRNLRQIFQSLPPFIDILLLLLFFMVIFAILGFCLFSANT 255

Human   331 SDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTF 395
            :|.|||||||||||||||||||||||||||:||:|.|||:|||||||||||||||||||||||||
Zfish   256 ADHYFSTLENSIVSLFVLLTTANFPDVMMPAYSKNRWSCIFFIVYLSIELYFIMNLLLAVVFDTF 320

Human   396 NDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 460
            |.:||.||||||||||:||:||::||:|::||.|:|.:||:||||||.|||:.|:|:|||||||.
Zfish   321 NGVEKMKFKSLLLHKRSAIEHAFQLLVSRQRPDGVSLKQFDGLMRFYHPRMTPRDRFLTFKALNH 385

Human   461 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAV 525
            :..|:|||:|||..|||..|||||:::.|||||:|||||||||||||:|||||||||.|||||||
Zfish   386 SGAPMLSLQDFYKFYEVIGLKWKARRSGEHWFDDLPRTALLIFKGINLLVKSKAFQYAMYLVVAV 450

Human   526 NGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFA 590
            ||:||||||.||..|..:::.|||||::||||||:|:.||:.||||:.|.|||||||||||||||
Zfish   451 NGIWILVETNMLNDGISWTRVVPWSYIIFLTIYGIEVLLKITGLGPITYFSSGWNLFDFSVTVFA 515

Human   591 FLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAI 655
            ||||:|||.:||||||||||||||||||||:|:||||||||||||.||||||||||:||||||||
Zfish   516 FLGLIALAFDMEPFYFIVVLRPLQLLRLFKIKQRYRNVLDTMFELFPRMASLGLTLIIFYYSFAI 580

Human   656 VGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNN 720
            ||||||..:::||||:.||||.:||..|.|.||||.::|||||||||:|||:|||||||||||||
Zfish   581 VGMEFFADVIYPNCCDNSTVAASYRQINVTTGNRTELQEGYYYLNNFNNILSSFVTLFELTVVNN 645

Human   721 WYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQ----DSEVDGGI 781
            |||.||||||||:||||||||||||||||||||||||||:||||||||||||:    |.|.:.||
Zfish   646 WYITMEGVTSQTTHWSRLYFMTFYIVTMVVMTIIVAFILDAFVFRMNYSRKNREPLDDPEDEKGI 710

Human   782 TLEKEISKEELVAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQ 846
            ..|.|:|:.|.:..|:.|:...|. :::|.|.:....:||..|.|:||||||||||||||:|||:
Zfish   711 VFETEVSQTEALQTLDFYKHTLGV-TNLTSLQDMCVALERSGQTSLVFLGRRSRTKSDLSMKMYE 774

Human   847 EEIQEWYEEHAREQEQ-----QRQLSSSAAPA 873
            |||||||||::|...|     .|:|.|..|.|
Zfish   775 EEIQEWYEEYSRTNLQTDGTFHRELDSPDAGA 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TPCN1	NP_001137291.1	Ion_trans	214..402	CDD:459842	162/187 (87%)
		Ion_trans	512..763	CDD:459842	201/250 (80%)
tpcn1	XP_695923.4	Ion_trans	139..325	CDD:459842	160/185 (86%)
		Ion_trans	437..688	CDD:459842	201/250 (80%)