DRSC/TRiP Functional Genomics Resources

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Protein Alignment NUP54 and Nup54

DIOPT Version :10

Sequence 1:NP_059122.2 Gene:NUP54 / 53371 HGNCID:17359 Length:507 Species:Homo sapiens
Sequence 2:NP_610783.1 Gene:Nup54 / 36360 FlyBaseID:FBgn0033737 Length:610 Species:Drosophila melanogaster


Alignment Length:510 Identity:205/510 - (40%)
Similarity:294/510 - (57%) Gaps:47/510 - (9%)


- Green bases have known domain annotations that are detailed below.


Human     5 FGAP---------SGTSGTAAATAAPAGGFGGFGTTSTTAGSAFSFSAPTNTGTTGLFGGTQNKG 60
            ||||         ||....|||:.|||.||.||||| ||:..||           |.||.:|:.|
  Fly   127 FGAPATSAAPPAFSGFGQQAAASTAPASGFSGFGTT-TTSAPAF-----------GGFGTSQSTG 179

Human    61 FG---FGTGFGTTTGTSTGLGTGLGTGLGFGG--FNTQQQQQTTLGGLFSQPTQAPTQSNQLINT 120
            ||   ||:.||....|:...|.|     ||||  |...|.||        ||  ||..:::..  
  Fly   180 FGGGAFGSTFGKPANTTVTPGFG-----GFGGTSFMLGQPQQ--------QP--APISADEAF-- 227

Human   121 ASALSAPTLLGDERDAILAKWNQLQAFWGTGKGYFNNNIPPVEFTQENPFCRFKAVGYSCMPSNK 185
            |.::...::.|||||.|:||||.|||.|||||.:::.:..||:.|.||..|||||:|||.||...
  Fly   228 AQSILNVSIFGDERDKIVAKWNYLQATWGTGKMFYSQSAAPVDITPENVMCRFKAIGYSRMPGKD 292

Human   186 DEDGLVVLVFNKKETEIRSQQQQLVESLHKVLGGNQTLTVNVEGTKTLPDDQTEVVIYVVER--- 247
            ::.|||.|.|.::.:.::..|||::::||.:.|....:.|:::..|.|.:.:.::||||.|:   
  Fly   293 NKLGLVALNFCRELSAVKPHQQQVIQTLHSLFGSKPNMLVHIDSIKELENKKCQIVIYVEEKLQH 357

Human   248 SPNGTSRRVPATTLYAHFEQANIKTQLQQLGVTLSMTRTELSPAQIKQLLQNPPAGVDPIIWEQA 312
            :|| .|:|:.||.|..:..||.:|.||..|||..::........|:::.|:|||.||||.:|.||
  Fly   358 APN-ESKRILATELSNYLNQATLKPQLNNLGVVEALALVLPDEDQLREYLENPPRGVDPRMWRQA 421

Human   313 KVDNPDSEKLIPVPMVGFKELLRRLKVQDQMTKQHQTRLDIISEDISELQKNQTTSVAKIAQYKR 377
            ..||||....||||||||.:|..|:|.|:|.|..|...:..:..:::||:|...|:.|||.::||
  Fly   422 NSDNPDPTLYIPVPMVGFNDLKWRVKCQEQETDTHALYIKKVESELTELKKRHATATAKILEHKR 486

Human   378 KLMDLSHRTLQVLIKQEIQRKSGYAIQADEEQLRVQLDTIQGELNAPTQFKGRLNELMSQIRMQN 442
            ||.:||||.|::::|||..||.|.::..:||.||.:|..:...::|||||||||:||:||:|||.
  Fly   487 KLAELSHRILRIIVKQECTRKVGTSLTPEEEALRTKLQNMLAVVSAPTQFKGRLSELLSQMRMQR 551

Human   443 HFGAVRSEERYYIDADLLREIKQHLKQQQEGLSHLISIIKDDLEDIKLVEHGLNE 497
            :..|......|.:|.:...|:|..|..||..:..|...:..||..:.::..||.|
  Fly   552 NQFAANGGAEYALDKEAEDEMKTFLTMQQRAMEVLSDTVNKDLRALDVIIKGLPE 606

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NUP54NP_059122.2 9 X 2 AA repeats of F-G 5..445 191/456 (42%)
Nup54 300..437 CDD:464011 66/136 (49%)
Nup54_C 453..491 CDD:465767 10/37 (27%)
Nup54NP_610783.1 Nucleoporin_FG 2..91 CDD:463941
Nucleoporin_FG 125..220 CDD:463941 47/119 (39%)
Nup54 409..546 CDD:464011 66/136 (49%)
Nup54_C 562..600 CDD:465767 10/37 (27%)
Blue background indicates that the domain is not in the aligned region.

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