DRSC/TRiP Functional Genomics Resources

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Protein Alignment PLCG2 and sgl

DIOPT Version :9

Sequence 1:NP_002652.2 Gene:PLCG2 / 5336 HGNCID:9066 Length:1265 Species:Homo sapiens
Sequence 2:NP_476980.1 Gene:sgl / 38760 FlyBaseID:FBgn0261445 Length:476 Species:Drosophila melanogaster


Alignment Length:421 Identity:73/421 - (17%)
Similarity:140/421 - (33%) Gaps:129/421 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    41 RTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFV 105
            |.:..|.::.::...|:...:.....||.|..               ..||....:.||...:|:
  Fly   110 RMIAEIAQSNKIVVEKSTVPVRAAESIMHILR---------------ANQKPGIHYDILSNPEFL 159

Human   106 LSTLSLAADSKEDAVN-WLSGLKIL---------HQEAMNASTPTIIESWLRKQIYSVDQTRRNS 160
                     ::..|:| .|:..::|         ||.....|  .|.|.|:.||......|..:.
  Fly   160 ---------AEGTAINDLLNADRVLIGGEETPEGHQAVEKLS--WIYEHWIPKQNILTTNTWSSE 213

Human   161 ISLRELKTILPLINFKVSSAKFLKDKFVEIGAHKDELS------------FEQFHLFYKKLMFEQ 213
            :|.......|..   ::||...|.......||...|::            |.|..:.:....|  
  Fly   214 LSKLAANAFLAQ---RISSINSLSAVCEATGADVSEVARAVGLDSRIGSKFLQASVGFGGSCF-- 273

Human   214 QKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQ--DLNKVRER--MTKFID 274
            ||.||      :.::|..|.:.|:.:|                :|.|  |:|:.::|  ..|.|:
  Fly   274 QKDIL------NLIYICENLNLPEVAA----------------YWQQVIDMNEYQKRRFSQKIIE 316

Human   275 DTMRETAEPFLFVDEFLTYLF------SRENS----------------IWDEKYDAVDMQDMNNP 317
            ......::..:.:   |.:.|      :||.:                |:|.|   |:.:.:.:.
  Fly   317 SLFNTVSDKRIAI---LGFAFKKNTGDTRETAAITVCQTLLEEGAALDIYDPK---VEPEQIIDD 375

Human   318 LSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKF 382
            |:|..::.|........|:.|:  |.:.:|.......|.|                |.....:.|
  Fly   376 LTHPSVTESPEKVKKAVQIHSD--PYSAVRATHALVICTE----------------WDEFVDLDF 422

Human   383 DDVVQAIKDHAFVTSSFPVILSIEEHCSVEQ 413
            ..:.|::...|::.....::    :|..::|
  Fly   423 KRIYQSMMKPAYIFDGRKIL----DHERLQQ 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLCG2NP_002652.2 PH_PLC_gamma 22..140 CDD:270168 18/108 (17%)
PH-like 235..>276 CDD:302622 9/44 (20%)
PI-PLCc_gamma 311..>458 CDD:176534 15/103 (15%)
PH-like 475..>510 CDD:302622
SH2_N-SH2_PLC_gamma_like 527..627 CDD:199829
SH2_C-SH2_PLC_gamma_like 641..744 CDD:198186
SH3_PLCgamma2 773..827 CDD:212902
PHsplit_PLC_gamma <840..910 CDD:270054
PI-PLCc_GDPD_SF <926..1031 CDD:301322
C2_PLC_like 1061..1187 CDD:175974
sglNP_476980.1 PLN02353 1..459 CDD:177986 73/421 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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