DRSC/TRiP Functional Genomics Resources

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Protein Alignment PLCG2 and Plc21C

DIOPT Version :10

Sequence 1:NP_002652.2 Gene:PLCG2 / 5336 HGNCID:9066 Length:1265 Species:Homo sapiens
Sequence 2:NP_995605.1 Gene:Plc21C / 33204 FlyBaseID:FBgn0004611 Length:1318 Species:Drosophila melanogaster


Alignment Length:1299 Identity:310/1299 - (23%)
Similarity:468/1299 - (36%) Gaps:486/1299 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    17 QIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLDIMEIKEIRPG---KN 78
            ::.:||:.|.....:.....|....|::|..:...:.|....:::: .|||..|:::|.|   |.
  Fly    15 EVPQALQDGEKFIRWDDDSGTGTPVTMRVDAKGFFLYWVDQNNELD-ILDIATIRDVRTGQYAKR 78

Human    79 SKDFERAKAVR-----QKEDCCFTILYGTQFV-LSTLSLAADSKEDAVNWLSGL-KILHQEA-MN 135
            .||.:..:.|.     ..|:...|:.:|:.|| ::.::.....::.|..|..|| |:.:..| :|
  Fly    79 PKDNKLRQIVTLGPQDTLEEKTVTVCHGSDFVNMTFVNFCCTRRDIAQLWTDGLIKLAYSLAQLN 143

Human   136 ASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKDKFVEI----GAHKDE 196
            .|....::....|....||::.|..:     |.|:.|........|.: :|.:::    ....|.
  Fly   144 GSAIMFLQKAHTKLCLQVDKSGRIPV-----KNIIKLFAQNKEDRKRV-EKALDVTGLPSGKVDS 202

Human   197 LS-----FEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQE 256
            :|     ||.|:..||.|   .|:|.::.. .||   |:||:.|...|...|.:|          
  Fly   203 ISVSKFQFEDFYNLYKYL---TQRSEVERL-FDS---IVGNSKRKCMSIAQLVEF---------- 250

Human   257 HWAQDLNKVRERMTKFIDDTMRETAEPF------------------------LFVDEFLTYLFSR 297
                 |||.:.      |..:.|...|:                        |.:|.||.||...
  Fly   251 -----LNKTQR------DPRLNEILYPYANPARAKELIQQYEPNKFNAQKGQLSLDGFLRYLMGD 304

Human   298 ENSIW-DEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCW 361
            :|.|. ..|.|..|  ||:.|:|||:|:|||||||||.||..:||.|.|.:||..||||:|||.|
  Fly   305 DNPIMAPSKLDLCD--DMDQPMSHYFINSSHNTYLTGHQLTGKSSVEIYRQCLLAGCRCVELDFW 367

Human   362 DGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFG 426
            :|...:|||.||:|...:|...||::||.:.||.||.:|||||.|.||:..||..:|...:|:||
  Fly   368 NGRTEEPVIVHGYTFVPEIFAKDVLEAIAESAFKTSEYPVILSFENHCNPRQQAKIANYCREIFG 432

Human   427 DLLLTK-----PTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGELYMWDS 486
            |:||.|     |.|.:.| ||.|:.||.|||||:||                             
  Fly   433 DMLLDKPLDSHPLEPNMD-LPPPAMLRRKIIIKNKK----------------------------- 467

Human   487 IDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELHFGEKWFHKKV---------EKRTS 542
                  :|:                               |......|||.         .|.|:
  Fly   468 ------KHH-------------------------------HHHHHHHHKKPAQVGTPAANNKLTT 495

Human   543 AE----KLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYYLTD 603
            |.    |..|:..:....:||..                          .|||..|.......|.
  Fly   496 ANSVDAKAAQQVGLSASHEDGGV--------------------------TRSTANGDVATGTGTG 534

Human   604 NLTFSSIYA-LIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDMLMRIPRDG 667
            :...::.:| .:|..|::                      ||.      |.|.::          
  Fly   535 SAAGTAGHAPPLQQIRQS----------------------SKD------STGSSD---------- 561

Human   668 AFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEKHSLYRKMRLR 732
                     |||                           |:..|||..                 
  Fly   562 ---------SDS---------------------------SSEDESLPN----------------- 573

Human   733 YPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDELSFCRGALIH 797
              .||.|                      ||...|. |:         ||::..|......||: 
  Fly   574 --TTPNL----------------------PSGNEPP-PE---------KAQKETEAGAEISALV- 603

Human   798 NVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVK 862
                                    |||:.|..:.||..||                         
  Fly   604 ------------------------NYVQPIHFSSFENAEK------------------------- 619

Human   863 APQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIA 927
                                                                       ||:.. 
  Fly   620 -----------------------------------------------------------KNRCY- 624

Human   928 IELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQRV 992
                                      |:.||.|.:|.::::::|::.:.||:..|:||||.|.|.
  Fly   625 --------------------------EMSSFDEKQATTLLKERPIEFVNYNKHQLSRVYPAGTRF 663

Human   993 DSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR--TEKYDPMPPES 1055
            ||||:.|...|..|.|:|||||||.|..||:|..:|..|.|:||:|:||.||  ..:.||....:
  Fly   664 DSSNFMPQLFWNAGCQLVALNFQTLDLAMQLNLGIFEYNARSGYLLKPEFMRRSDRRLDPFAEST 728

Human  1056 QRKILM-TLTVKVLGARHLPKLGRSIACPFVEVEICGAEYD--NNKFKTTVVNDNGLSPIWAPTQ 1117
            ...|:. |:::.||..:.|..   ..|..||||::.|...|  ..||:|..|.|||::|::  .:
  Fly   729 VDGIIAGTVSITVLSGQFLTD---KRANTFVEVDMYGLPADTVRKKFRTKTVRDNGMNPLY--DE 788

Human  1118 EKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLL 1181
            |...| ::..|.||.:|...|||    ....:.|...|:..:..|:|.|.|::...:.|.||||.
  Fly   789 EPFVFKKVVLPELASIRIAAYEE----GGKLIGHRVLPVIGLCPGYRHVNLRSEVGQPIALASLF 849

Human  1182 VFCEMRPVLESE-----EEL-----YSSCRQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEF 1235
            :...::..:..:     |.|     |.|  :|.:|..:|:   .|.|..:.|.:|:.| |.|.|
  Fly   850 LCVVVKDYVPDDLSNFAEALANPIKYQS--ELEKRDIQLS---VLTDEAEALGSADED-LSKSF 907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLCG2NP_002652.2 PH_PLC_gamma 22..140 CDD:270168 29/128 (23%)
EFh_PI-PLCgamma2 145..298 CDD:320045 40/185 (22%)
PI-PLCc_gamma 311..>458 CDD:176534 80/151 (53%)
PH-like 475..>510 CDD:473070 1/34 (3%)
SH2_N-SH2_PLC_gamma_like 527..627 CDD:199829 19/113 (17%)
SH2_C-SH2_PLC_gamma_like 641..744 CDD:198186 14/102 (14%)
SH3_PLCgamma2 773..827 CDD:212902 8/53 (15%)
PHsplit_PLC_gamma <840..910 CDD:270054 0/69 (0%)
PI-PLCc_GDPD_SF <926..1031 CDD:472694 35/104 (34%)
C2_PLC_like 1061..1187 CDD:175974 39/129 (30%)
Plc21CNP_995605.1 PH_PLC_beta 20..145 CDD:270167 28/125 (22%)
EFh_PI-PLC21 151..305 CDD:320043 40/187 (21%)
EF-hand motif 151..180 CDD:320043 7/33 (21%)
EF-hand motif 187..216 CDD:320043 6/28 (21%)
EF-hand motif 225..255 CDD:320043 12/48 (25%)
EF-hand motif 272..305 CDD:320043 6/32 (19%)
PI-PLCc_beta 317..702 CDD:176533 170/740 (23%)
C2_PLC_like 736..855 CDD:175974 39/127 (31%)
PTZ00121 <981..>1253 CDD:173412
Blue background indicates that the domain is not in the aligned region.

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