DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLCG2 and norpA

DIOPT Version :9

Sequence 1:NP_002652.2 Gene:PLCG2 / 5336 HGNCID:9066 Length:1265 Species:Homo sapiens
Sequence 2:NP_001014720.1 Gene:norpA / 31376 FlyBaseID:FBgn0262738 Length:1095 Species:Drosophila melanogaster


Alignment Length:1274 Identity:279/1274 - (21%)
Similarity:439/1274 - (34%) Gaps:514/1274 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    60 KIEG----FLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQF-VLSTLSLAADSKEDA 119
            |.||    .:::.::.:||.|...||.:....|.:|.        ||.. .|...||...|..|.
  Fly    56 KSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKN--------GTNIPELDKRSLTICSNTDY 112

Human   120 VN----------------WLSGL-KILHQEAMNASTPTII--ESWLRKQIYSVDQTRRNSISLRE 165
            :|                ||.|: ||.|....|...|.:.  :.|:|.. |.|:::  ..|.::.
  Fly   113 INITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKHWMRLS-YCVEKS--GKIPVKT 174

Human   166 L-KTIL-----PLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLM----FEQQKSILDE 220
            | ||..     .|:...:..|....||...:  .|::.:|::|:..|.|:.    .|:..:.:.:
  Fly   175 LAKTFASGKTEKLVYTCIKDAGLPDDKNATM--TKEQFTFDKFYALYHKVCPRNDIEELFTSITK 237

Human   221 FKKDSSVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKV------RERMTKFI-----D 274
            .|:|               .:.|..|.:|:..:|::   ..:|::      .:|.|:.|     |
  Fly   238 GKQD---------------FISLEQFIQFMNDKQRD---PRMNEILYPLYEEKRCTEIINDYELD 284

Human   275 DTMRETAEPFLFVDEFLTYLFSRENS-IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRS 338
            :..::..:  :.:|.|..||.|.||: ::.::.|.  ..:|:.||:||:|:|||||||:|.|:..
  Fly   285 EEKKKNVQ--MSLDGFKRYLMSDENAPVFLDRLDF--YMEMDQPLAHYYINSSHNTYLSGRQIGG 345

Human   339 ESSPEAYIRCLRMGCRCIELDCWD--GPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPV 401
            :||.|.|.:.|..||||:|||||:  |.|.:|::.||....|:|.|.|.:|||.|.|||:|.:||
  Fly   346 KSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPV 410

Human   402 ILSIEEHCSVEQQRHMAKAFKEVFGDLLLTKP-TEASAD---QLPSPSQLREKIIIKHKKLGPRG 462
            |||.|.||:..||..:||...:.||||||.:| .:...|   .||.|.:|:.||:||:|::.|  
  Fly   411 ILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKP-- 473

Human   463 DVDVNMEDKKDEHKQQGELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTMEEEVPQDIPPTELH 527
                        ..::.||.:|              ...:|...||.|:......|.:...... 
  Fly   474 ------------EVEKVELELW--------------LKGELKTDDDPEEDASAGKPPEAAAAPA- 511

Human   528 FGEKWFHKKVEKRTSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTM 592
                   ...|...:||.     ..|.||.      .|:|....:|:                  
  Fly   512 -------PAPEAAAAAEG-----AAEGGGG------AEAEAAAANYS------------------ 540

Human   593 EGGTLKYYLTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAE 657
             |.|                                         .|.|   ||           
  Fly   541 -GST-----------------------------------------TNVH---PW----------- 549

Human   658 DMLMRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYEK 722
                                                                ..|:|        
  Fly   550 ----------------------------------------------------LSSMV-------- 554

Human   723 HSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDYKAKRSDE 787
                                                                             
  Fly   555 ----------------------------------------------------------------- 554

Human   788 LSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQIIEDNPLGSLCRGI 852
                                              ||.:.|.   |:..:|.|             
  Fly   555 ----------------------------------NYAQPIK---FQGFDKAI------------- 569

Human   853 LDLNTYNVVKAPQGKNQKSFVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNM 917
                                                                             
  Fly   570 ----------------------------------------------------------------- 569

Human   918 KYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGL 982
               |||  ||..:|                         ||.|:...:.::|..:|.:.||::.:
  Fly   570 ---EKN--IAHNMS-------------------------SFAESAGMNYLKQSSIDFVNYNKRQM 604

Human   983 TRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR--T 1045
            :|:||||.|.|||||.|...|..|.|||:||||::|..||:|...|..||..||:|:|:.||  .
  Fly   605 SRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRAD 669

Human  1046 EKYDPM---PPESQRKILMTLTVKVLGARHL--PKLGRSIACPFVEVEICGAEYDNNK--FKTTV 1103
            :.:||.   |.:.  .|....:|||:..:.|  .|:|     .:|||::.|...|..|  |:|.:
  Fly   670 KDFDPFADAPVDG--VIAAQCSVKVIAGQFLSDKKVG-----TYVEVDMFGLPSDTVKKEFRTRL 727

Human  1104 VNDNGLSPIWAPTQEKVTF-EIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSGFRSVPL 1167
            |.:|||:|::  .::...| ::..|:||.|||.||||    ....|.....|:..:::|:|.|.|
  Fly   728 VANNGLNPVY--NEDPFVFRKVVLPDLAVLRFGVYEE----SGKILGQRILPLDGLQAGYRHVSL 786

Human  1168 KNGYSEDIELASLLVFCEMRPVL----ESEEELYSSCRQLRRRQEELNNQLFLYDTHQNLRNANR 1228
            :...:..:.|..|.|..|::..:    |....:.|..|......::.|.|:......:....|.|
  Fly   787 RTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIEEQSGGAAR 851

Human  1229 DA-LVKEFSVNENQL--------QLYQEKCNKRLREKRV 1258
            || ..||....|..|        .|.|||..:::.:|::
  Fly   852 DAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQI 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLCG2NP_002652.2 PH_PLC_gamma 22..140 CDD:270168 25/101 (25%)
PH-like 235..>276 CDD:302622 9/51 (18%)
PI-PLCc_gamma 311..>458 CDD:176534 75/152 (49%)
PH-like 475..>510 CDD:302622 6/34 (18%)
SH2_N-SH2_PLC_gamma_like 527..627 CDD:199829 11/99 (11%)
SH2_C-SH2_PLC_gamma_like 641..744 CDD:198186 5/102 (5%)
SH3_PLCgamma2 773..827 CDD:212902 2/53 (4%)
PHsplit_PLC_gamma <840..910 CDD:270054 0/69 (0%)
PI-PLCc_GDPD_SF <926..1031 CDD:301322 36/104 (35%)
C2_PLC_like 1061..1187 CDD:175974 40/130 (31%)
norpANP_001014720.1 PH_PLC_beta 17..149 CDD:270167 25/100 (25%)
PLN02952 224..786 CDD:178538 213/987 (22%)
EF-hand_like 227..318 CDD:286375 20/112 (18%)
PI-PLCc_beta 318..653 CDD:176533 146/725 (20%)
C2_PLC_like 689..806 CDD:175974 40/127 (31%)
DUF1154 866..908 CDD:284131 6/25 (24%)
Mer2 <887..1003 CDD:286200 1/4 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D368239at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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