DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PLCG1 and sl

DIOPT Version :10

Sequence 1:XP_005260495.1 Gene:PLCG1 / 5335 HGNCID:9065 Length:1330 Species:Homo sapiens
Sequence 2:NP_476726.2 Gene:sl / 32601 FlyBaseID:FBgn0003416 Length:1236 Species:Drosophila melanogaster


Alignment Length:1323 Identity:527/1323 - (39%)
Similarity:760/1323 - (57%) Gaps:189/1323 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    16 APSDAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADK-----IEGAIDI 75
            ||...|:......||.||::|..|.|: :||:|:...:..||||:.|:..|.:     .||||.:
  Fly     9 APLLGEMEQTIGMLERGTIVTKLYGKQ-RRPDRRHLMLIRETRQLLWATVATQTPRTDYEGAIQL 72

Human    76 REIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTWL 140
            |||:|||.||.|::|..:.:| ..|.:.|.|||||:|..|:||:.|:.|.||.|.:.|::||.::
  Fly    73 REIREIRVGKHSKEFRLFADD-CQRFESSKCFVILHGNHFKLKSFSVVALSEIEADNWVRGLRYM 136

Human   141 MEDTLQAPTPLQIERWLRKQFYSVD----------RNREDRISAKDLKNMLSQVNYRVPNMRFLR 195
            ::|||.||.||||:||||:::|.::          .....:::.||.|..|:.|:.::...:|: 
  Fly   137 VKDTLGAPYPLQIDRWLRREYYQIENVNTHSAKATEQSPAQVTIKDFKLFLAGVSCKMTTGKFM- 200

Human   196 ERLTDLEQRSGDITYGQFAQLYRSLM--------YSAQKTMDLPFLEASTLRAGERPELCRVSLP 252
            |..|:..:|..|:.:..|::||:.|:        .|.....:.|:.|...:   .||       .
  Fly   201 EHFTEDVRRKHDLKFDDFSRLYQKLLLPNGFASVLSGSGVANFPYSEDQQV---VRP-------A 255

Human   253 EFQQFLLDYQGELWA--VDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWNSQLD 315
            |.:|||...|.::.|  :....:..|:..|::|..|:::|||....|||.|||||:|.:|||:.|
  Fly   256 ELKQFLETEQRDVSASEISSAAIASFIRDFVQDVERDVQEPYLTFPEFVDFLFSKQNDLWNSKYD 320

Human   316 AVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYH 380
            .|..| ||.|||.|||:|||||||||||||||||.|||||.|||||||||||||:|||.:|.|:|
  Fly   321 QVFMD-MNLPLSSYWIASSHNTYLTGDQFSSESSCEAYARALRMGCRCIELDCWNGPDNLPYIFH 384

Human   381 GHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKKVLGDTLLTKPVEIS 445
            |||:|:||||.||:.|||:|||.:||||||||||.:||:.|||||||...:|.||.|||:|.:.:
  Fly   385 GHTITSKIKFMDVIKTIKDHAFTSSEYPVILSIEQNCSLEQQRNMAQALIEVFGDMLLTQPCDRN 449

Human   446 ADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSM------------------MYSEND---ISNS 489
            ...||||.||:|||::|||||.:   ::::...:                  .:.|||   :...
  Fly   450 EQHLPSPYQLRRKIILKHKKLPQ---FDDIANGISSTGSLGHRSSLGGAGGGAHGENDGENVRKV 511

Human   490 IKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEE-TSSDQGNEDEEE----------------PKE 537
            .|.|:||.:|||:..|..:.||||..::.||.| ..|..||.::::                .|:
  Fly   512 FKEGLLYFKDPVDKSWNLYQFVLTHQELIYSSEINESRNGNSEDDDFGLSSSCSLNSNMQQKQKD 576

Human   538 VSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRN 602
            .|::.|||..|.||||||   ..||..|:.||.:|   ....||:||||||.||||||:|||||.
  Fly   577 TSANDELHFGENWFHGKL---EGGRKEADDLLKKY---KHFGDGTFLVRESATFVGDYSLSFWRR 635

Human   603 GKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNAHESKE 667
            .:..||||..:.:.|:.|::|.:|.||||||.||.:|::..||.:||.:.|.|||||...||.:|
  Fly   636 NRPNHCRIKLKHENGSIKYYLVENFVFDSLYSLIVYYRKNMLRSSEFSIILKEPVPQPKKHEDQE 700

Human   668 WYHASLTRAQAEHMLMRVPRDGAFLVRKRNEP-NSYAISFRAEGKIKHCRVQQEGQTVMLGNSEF 731
            |:|.:.|:.|||..|.|: ..|:||||...:. |::.|||....||||||:.|||:...:....|
  Fly   701 WFHPNTTKEQAEQGLYRL-EIGSFLVRPSVQSINAFVISFTINRKIKHCRIMQEGRLYGIDTMNF 764

Human   732 DSLVDLISYYEKHPLYRKMKLRYPINEEALEK--IGTAEPDYGALYEGRNPGFYVEANPMPTFKC 794
            :|||.||:||.::||||.:||.:|:::|.|.:  ...|:.|:...::......|:.:|......|
  Fly   765 ESLVSLINYYTRNPLYRNVKLSHPVSQELLRQALAEAAQGDHSGGHDDNGASNYMGSNLEENVTC 829

Human   795 AVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQLWFPSNYVEEMVNPVALEPER 859
              |||:.|||.:.|||:|.|.|||.||::....||.|||||..:...|:|||:      .::...
  Fly   830 --KALYSYKANKPDELSFPKHAIITNVQRDNSMWWIGDYGGMIKKHLPANYVK------VIDSTT 886

Human   860 EHLDENSPLGDLLRGVLDVPACQIAIRPEGKNNR---------------------LFVFSISMAS 903
            |  |.||                  :..||.:.|                     :|...|...:
  Fly   887 E--DYNS------------------LNEEGTDGRTDSIEIFGAVASLFESNDPGIIFKLQIQTPT 931

Human   904 VAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDEE 968
            :.: ...:..|:||...:|:|.|:|.|..|....:|.:..||..::|.|:|:|::|.|.|||.|.
  Fly   932 MQN-PFVIGFDNQETAYEWIKAIQEAALIASQLASERRKKERTARVAKEMSDLIIYFRSVPFREH 995

Human   969 KIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGS 1033
            .     ..:::|||||||||||...:...:.||.|:|.|:||:|||||||||||::|:|.|..||
  Fly   996 S-----WIFQEMSSFPETKAEKQFFQQNTQLFLSYHRNQISRVYPKGQRLDSSNFNPMPFWNVGS 1055

Human  1034 QLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGAR 1098
            |::|||:||.||.||:|||.|.....|||:|:||.|:.::|:| :.....||....:||.::.||
  Fly  1056 QMIALNYQTGDKAMQLNQAKFRNNGQCGYILKPSFMKSDSFNP-NNPLCDGLSEVKVSIRLIAAR 1119

Human  1099 HLPKNGRGIVCPFVEIEVAGAEYDS-TKQKTEFVGQSVFPVILLILLGHCKPLPTSHPILSHGDL 1162
            ||.:.|:. ..|.:.:|:.||.:|: .|.:|:                                 
  Fly  1120 HLFRGGKS-NNPQIVVELIGASFDTGVKYRTK--------------------------------- 1150

Human  1163 KPFVVAFTVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYR 1227
                   ..:||.|||| .:...|.:.||:||.|||.|.:||||::.:|:|||.:|:..::.|||
  Fly  1151 -------VNENGFNPVW-NESCEFNVRNPQFAILRFEVQDEDMFAETHFIAQACYPLTCIRQGYR 1207

Human  1228 AVPLKNNYSEDLELASLLIKIDI 1250
            :|.|:|.:||:|||:||||.|.|
  Fly  1208 SVILRNKFSEELELSSLLINIKI 1230

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLCG1XP_005260495.1 PH_PLC_gamma 29..151 CDD:270168 55/126 (44%)
EFh_PI-PLCgamma1 156..306 CDD:320044 43/169 (25%)
EF-hand motif 156..185 CDD:320044 8/38 (21%)
EF-hand motif 193..221 CDD:320044 8/27 (30%)
EF-hand motif 226..262 CDD:320044 8/35 (23%)
EF-hand motif 272..306 CDD:320044 14/33 (42%)
PI-PLCc_gamma 319..>466 CDD:176534 104/146 (71%)
PH-like 489..>523 CDD:473070 15/34 (44%)
SH2_N-SH2_PLC_gamma_like 545..649 CDD:199829 52/103 (50%)
SH2_C-SH2_PLC_gamma_like 663..765 CDD:198186 46/104 (44%)
SH3_PLCgamma1 791..850 CDD:212903 28/58 (48%)
PHsplit_PLC_gamma <864..933 CDD:270054 15/89 (17%)
PLCYc 954..1069 CDD:128454 62/114 (54%)
C2_PLC_like 1087..1250 CDD:175974 54/163 (33%)
slNP_476726.2 PH_PLC_gamma 22..147 CDD:270168 55/126 (44%)
EFh_PI-PLCgamma 152..311 CDD:320031 43/169 (25%)
EF-hand motif 152..191 CDD:320031 8/38 (21%)
EF-hand motif 198..226 CDD:320031 8/28 (29%)
EF-hand motif 230..265 CDD:320031 9/44 (20%)
EF-hand motif 277..311 CDD:320031 14/33 (42%)
PI-PLCc_gamma 323..>470 CDD:176534 104/147 (71%)
SH2_N-SH2_PLC_gamma_like 584..682 CDD:199829 52/103 (50%)
SH2_C-SH2_PLC_gamma_like 696..796 CDD:198186 46/100 (46%)
SH3_PLCgamma 828..880 CDD:212759 27/53 (51%)
PLCYc 981..1091 CDD:128454 62/114 (54%)
C2_PLC_like 1109..1215 CDD:175974 44/147 (30%)

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