Protein Alignment ZFYVE1 and CG6051

DIOPT Version :9

• Sequence 1: NP_067083.1
• Gene: ZFYVE1 / 53349
• HGNCID: 13180
• Length: 777
• Species: Homo sapiens
• Sequence 2: NP_001097943.1
• Gene: CG6051 / 43271
• FlyBaseID: FBgn0039492
• Length: 989
• Species: Drosophila melanogaster
• Alignment Length: 634
• Identity: 119/634 - (18%)
• Similarity: 203/634 - (32%)
• Gaps: 224/634 - (35%)

Human   131 EAEEMDEETKRKKMTEKVVS------FLLVDEN-------EEIQVTN------------------ 164
            :.|..|:.|..:::.:.:||      :|:.:.|       :|:.:|:
  Fly   457 DIESSDDGTDEEQLLKDIVSADCASGYLIPNTNLGNLLQPQEVPLTDNFVASEDDEYGTAEQQGH 521

Human   165 ---EED-------------FIRKL-----DCKP----------DQHLKVVSIFGNTGDGKS---H 195
               |||             .:::|     |.:|          ::|::..|  |...|..|   |
  Fly   522 QGLEEDEPSTSAAMLAATRTLQRLRLPSSDNEPLAEPTTIKASEEHMQQPS--GRHRDSHSHRHH 584

Human   196 TLNHTFFYGREVFK-----------TSPTQESCTVGVWAAYDP-------VHKVAVIDTEGL--L 240
            ..:|...:.|...:           |...::.|::   .|.||       ...:|..||...  |
  Fly   585 QRHHHHHHHRHPHQHQHRQPHPHRTTRSGRKRCSL---EAADPERIQPDREQNLASGDTSAASSL 646

Human   241 GATVNLSQR-TRLLLKVLAISDLVIYRTHADRLHNDLFKFLGDASEAYLKHFTKELK-------- 296
            ...|:|:.| |...||         :::..:.||. ||..:...::....:|..:|:
  Fly   647 SDDVSLAMRNTTARLK---------FKSTENLLHR-LFVCIAGVADQLQTNFASDLRQILRSVFL 701

Human   297 --ATTARCGLDVPLSTLGPAVIIFHET---VHTQLLGSDH----PSEVPEKLIQDRFRKLGRFPE 352
              .:||:..:|:|..|....:..|..:   |..:..||:.    ..||..:|  |.....|...:
  Fly   702 MNMSTAQEEIDIPEKTKESELFEFRASENDVIQESAGSNQSIYSAEEVNPEL--DNVFSAGGGNQ 764

Human   353 AFSSIHYKGTRTYNPPTDFSGLRRALEQLLENNTTRSPRHPGVIFKALKALSDRFSGEIPDDQMA 417
            |....|..|.                 .:..|||......||
  Fly   765 ATGQRHSAGA-----------------SMQRNNTIDLASQPG----------------------- 789

Human   418 HSSFFPDEYFTCSSLCLSCGVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEV 482
                                           ||.|..|.:....||...:|        ..|::.
  Fly   790 -------------------------------EGSPSGATTATSRSHVTRSR--------SLGDQE 815

Human   483 SVVPKTSASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTD 547
            :....||::.....:...:......:       .:.|.|....|:..|...          ..|.
  Fly   816 AASSATSSTAQLRQLEQQQQQQQLQI-------QLQRQRNNSVGSNTPSSA----------SSTS 863

Human   548 GFLKDNNNAAQRLLDGMNFMAQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFK 612
            ...:.|:..:.|  .|.....||.:|..: |:.|.::..|  ::|..|.|:.:...|..|.|.|.
  Fly   864 SSSEQNSPVSAR--SGSRRRLQSNNETQM-PSSATSTSAT--LSPPAWIPDGKAPRCMACQTPFT 923

Human   613 DNDTKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCY--EARN 659
            ....:||||.||..||..||:.:.|:|:.|...| ||||.:||  |.|:
  Fly   924 AFRRRHHCRNCGGVFCGVCSNASAPLPKYGLTKA-VRVCRDCYVREVRS 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZFYVE1	NP_067083.1	GBP	174..410	CDD:206650	52/286 (18%)
		Required for localization in the lipid droplets. /evidence=ECO:0000269|PubMed:30970241, ECO:0000269|PubMed:31293035	416..777		53/246 (22%)
		FYVE_like_SF	594..655	CDD:333710	24/60 (40%)
		FYVE_ZFYV1	711..771	CDD:277273
CG6051	NP_001097943.1	FYVE_LST2	902..966	CDD:277270	26/64 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149920
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840