DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZFYVE1 and Hrs

DIOPT Version :9

Sequence 1:	NP_067083.1	Gene:	ZFYVE1 / 53349	HGNCID:	13180	Length:	777	Species:	Homo sapiens
Sequence 2:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	291	Identity:	64/291 - (21%)
Similarity:	97/291 - (33%)	Gaps:	85/291 - (29%)

- Green bases have known domain annotations that are detailed below.

Human   375 RRALEQLLENNTTR---SPRHPGVIFKALKALSDRFSGEIPDDQMAHSSFFPDEYFTCSSLCLSC 436
            |.:.::.|||.|:.   .|..|.::...              |::......|...|
  Fly     3 RSSFDKNLENATSHLRLEPDWPSILLIC--------------DEINQKDVTPKNAF--------- 44

Human   437 GVGCKKSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGEEVSVVPKTSASTDSPWMGLAK 501
             ...||.||...   ||                   .:||......|:|....|.....
  Fly    45 -AAIKKKMNSPN---PH-------------------SSCYSLLVLESIVKNCGAPVHEE------ 80

Human   502 YAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVR--TEIVHVWPGTDGFLKDNNNAAQRLLDGM 564
                  |....|| .::.|    |....|.:.|.:  .|:|..|    .:...:::..|.:.|.|
  Fly    81 ------VFTKENC-EMFSS----FLESTPHENVRQKMLELVQTW----AYAFRSSDKYQAIKDTM 130

Human   565 NFM---AQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNKCATSFKDNDTKHHCRACGEG 626
            ..:   ..:..||     :...:..|...|| .|....   .|::|...|...:.|||||.||:.
  Fly   131 TILKAKGHTFPEL-----READAMFTADTAP-NWADGR---VCHRCRVEFTFTNRKHHCRNCGQV 186

Human   627 FCDSCSSKTRPVPERGWGPAPVRVCDNCYEA 657
            ||..|::|..|:|:.|. ...|||||.|:.|
  Fly   187 FCGQCTAKQCPLPKYGI-EKEVRVCDGCFAA 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZFYVE1	NP_067083.1	GBP	174..410	CDD:206650	7/37 (19%)
		Required for localization in the lipid droplets. /evidence=ECO:0000269\|PubMed:30970241, ECO:0000269\|PubMed:31293035	416..777		56/247 (23%)
		FYVE_like_SF	594..655	CDD:333710	23/60 (38%)
		FYVE_ZFYV1	711..771	CDD:277273
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	34/206 (17%)
		FYVE_Hrs	157..217	CDD:277260	25/64 (39%)
		Hrs_helical	377..471	CDD:289018
		GBP_C	<456..520	CDD:303769
		coiled coil	501..512	CDD:293879
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1818
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900