Protein Alignment BCL11A and bcl11aa

DIOPT Version :10

• Sequence 1: NP_075044.2
• Gene: BCL11A / 53335
• HGNCID: 13221
• Length: 835
• Species: Homo sapiens
• Sequence 2: NP_001035481.1
• Gene: bcl11aa / 678650
• ZFINID: ZDB-GENE-060421-4643
• Length: 829
• Species: Danio rerio
• Alignment Length: 875
• Identity: 655/875 - (74%)
• Similarity: 722/875 - (82%)
• Gaps: 86/875 - (9%)

Human     1 MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPL--GAPEGDHDLLTCGQCQMNFPLGDILIF 63
            |||||||||||||||:||||||.|:::::..:...|  .|||||.||||||||||||||||||||
Zfish     1 MSRRKQGKPQHLSKRDFSPEPLSAVVSEERQEQRGLVQVAPEGDQDLLTCGQCQMNFPLGDILIF 65

Human    64 IEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIA 128
            ||||||||||:||::||||||||||..|:::||||||||:||||||||||||||||||||||:|.
Zfish    66 IEHKRKQCNGTLCMDKAVDKPPSPSHGELRRASNPVEVGVQVTPEDDDCLSTSSRGICPKQENIT 130

Human   129 DKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTH 193
            .                                  ||||||||||||||||:|||||||||||||
Zfish   131 G----------------------------------KDEPSSYTCTTCKQPFSSAWFLLQHAQNTH 161

Human   194 GLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGR 258
            |.|||||||.|||||||||.|||:||:|.|||||||||:.:.:||||||||.| .|:...|.|||
Zfish   162 GFRIYLESERGSPLTPRVGAPSGMGADCSSQPPLHGIHLPEGSPFNLLRIPNS-GRDGPPLREGR 225

Human   259 FPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELA 323
            ||||||||||||||||||||:|.|..||:||||||||||||||||||:.|:||||||||||||||
Zfish   226 FPPTPPLFSPPPRHHLDPHRMEHLSPEELALATHHPSAFDRVLRLNPIPMDPPAMDFSRRLRELA 290

Human   324 GNT--SSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPL------QSAPPP----SQPPVKS 376
            |||  |:|||||.|||||||||||||.|:|||||:|||||.:      ||.|.|    |..|:|:
Zfish   291 GNTSGSTPPLSPNRPSPMQRLLQPFQSGTKPPFLSTPPLPSMQSPSGSQSTPTPLNQQSNTPMKT 355

Human   377 KSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDG 441
            ||||||||||||||||:||||||||||||||:||||||||||||||||||||:||||.|||||||
Zfish   356 KSCEFCGKTFKFQSNLIVHRRSHTGEKPYKCHLCDHACTQASKLKRHMKTHMNKSSPTTVKSDDG 420

Human   442 LSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELT 506
            |||||||||||||||||||:|||||||||||||| .:|||||:|||||::|||||||||||||..
Zfish   421 LSTASSPEPGTSDLVGSASNALKSVVAKFKSEND-RMIPENGEEEEEEEEEEEEEEEEEEEEEEG 484

Human   507 ESE---------------------RVDYGFGLSLEAARHHENSSRGAVVGVGDESRALPDVMQGM 550
            |.|                     |.:|.|.|:|:|||||||:  |..:|.....|:||:|||||
Zfish   485 EEEELERERERERERERERDRDGGRNNYHFSLNLQAARHHENN--GGRLGEDGIPRSLPEVMQGM 547

Human   551 VL-SSMQHFSEAFHQVLGEKHKRGHL-AEAEGHRDTCDEDSVAGESDRIDDG---TVNGRGCSPG 610
            .| :||||:||||||     ||||.| ::.:.|||.||||| |.||||:|:|   .:||||.||.
Zfish   548 GLAASMQHYSEAFHQ-----HKRGALNSDNDAHRDMCDEDS-ALESDRVDEGCGSAINGRGSSPS 606

Human   611 ESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLS 675
            ||||.|||||||||||||||||||||||||:|||....:|||||||||||||||||||||||||:
Zfish   607 ESASVGLSKKLLLGSPSSLSPFSKRIKLEKDFDLSTPTIPNTENVYSQWLAGYAASRQLKDPFLN 671

Human   676 FGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRR 740
            |||||||||||||||||||||||||||||:||||:||||||||||||||:.  ||||||||:|||
Zfish   672 FGDSRQSPFASSSEHSSENGSLRFSTPPGDLDGGVSGRSGTGSGGSTPHLG--GPGRPSSKDGRR 734

Human   741 SDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEIC 805
            :||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   735 TDTCEFCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEIC 799

Human   806 KMPFSVYSTLEKHMKKWHSDRVLNNDIKTE 835
            :||||||||||||||||||||.|:.:||||
Zfish   800 QMPFSVYSTLEKHMKKWHSDRPLSTEIKTE 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCL11A	NP_075044.2	Required for nuclear body formation and for SUMO1 recruitment. /evidence=ECO:0000250	1..210		144/210 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		25/41 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..376		40/64 (63%)
		zf-C2H2	378..399	CDD:395048	19/20 (95%)
		C2H2 Zn finger	379..399	CDD:275368	18/19 (95%)
		zf-H2C2_2	391..416	CDD:463886	22/24 (92%)
		C2H2 Zn finger	407..427	CDD:275368	18/19 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..458		34/36 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..512		31/61 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	572..619		30/50 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	678..740		54/61 (89%)
		DNA-binding. /evidence=ECO:0000269|PubMed:39423807, ECO:0007744|PDB:6U9Q, ECO:0007744|PDB:8TLO	737..835		89/97 (92%)
		zf-C2H2	743..764	CDD:395048	19/20 (95%)
		C2H2 Zn finger	744..764	CDD:275368	18/19 (95%)
		zf-H2C2_2	756..781	CDD:463886	24/24 (100%)
		Disordered. /evidence=ECO:0000269|PubMed:39423807	765..769		3/3 (100%)
		C2H2 Zn finger	772..792	CDD:275368	19/19 (100%)
		Disordered. /evidence=ECO:0000269|PubMed:39423807	793..799		5/5 (100%)
		C2H2 Zn finger	802..820	CDD:275368	16/17 (94%)
bcl11aa	NP_001035481.1	COG5048	326..>411	CDD:227381	63/84 (75%)
		C2H2 Zn finger	358..378	CDD:275368	18/19 (95%)
		zf-H2C2_2	370..395	CDD:463886	22/24 (92%)
		C2H2 Zn finger	386..406	CDD:275368	18/19 (95%)
		zf-C2H2	737..758	CDD:395048	19/20 (95%)
		C2H2 Zn finger	738..758	CDD:275368	18/19 (95%)
		zf-H2C2_2	750..775	CDD:463886	24/24 (100%)
		C2H2 Zn finger	766..786	CDD:275368	19/19 (100%)
		C2H2 Zn finger	796..814	CDD:275368	16/17 (94%)