DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BCL11A and Cph

DIOPT Version :10

Sequence 1:NP_075044.2 Gene:BCL11A / 53335 HGNCID:13221 Length:835 Species:Homo sapiens
Sequence 2:NP_001356899.1 Gene:Cph / 31660 FlyBaseID:FBgn0029939 Length:1254 Species:Drosophila melanogaster


Alignment Length:1202 Identity:309/1202 - (25%)
Similarity:422/1202 - (35%) Gaps:517/1202 - (43%)


- Green bases have known domain annotations that are detailed below.


Human    32 DHGPLGAPEGD---------HDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKP--- 84
            |||.......|         .|:||||.||..|.|.||:.||:||..|||.....:.|...|   
  Fly    11 DHGFRSLSHSDSTENDAVATQDILTCGACQKAFALSDIVKFIQHKVLQCNKENYGQCATQNPQMD 75

Human    85 ------------------------------------------------------------PSPSP 89
                                                                        |.|||
  Fly    76 RDAEEGRPLSLVNRRPSISAPISGRKSAPASAAAAVAAAAAAAAAAAAASSTASGSRIHTPPPSP 140

Human    90 IEM---KKASNP---VEVGIQVTPEDDDCLST------------------SSRGIC--------- 121
            .::   ..:|.|   |:.....||:|.:..:|                  |....|         
  Fly   141 ADLLADGASSTPKRLVDENDNTTPKDSETGATTLDSNAAPSSPAAIERQSSGDSSCEMEEQQDRQ 205

Human   122 -----PKQEHIADKLLHWRGLSSPRS---------AHGALIPTPGMSAEYAPQGICKDEPSSYTC 172
                 |||..:..:.....|::..::         ...:|...|.|....|.......|||:|||
  Fly   206 DKQSQPKQAKVKQEPYDEEGVNHHQNQDDDDDEEMEERSLAKRPKMELVDAEANTVHTEPSNYTC 270

Human   173 TTCKQPFTSAWFLLQHAQNTHGLRIYLESEHG--------------------------------- 204
            :|||..:||||.|:||.|::||::||:||..|                                 
  Fly   271 STCKTRYTSAWRLIQHVQHSHGVKIYVESPGGGATLTVATPAALNNSALALAAAAAAASASGLAS 335

Human   205 ------------------SPL------------------------------TPRVGIP------- 214
                              |||                              |..:|.|       
  Fly   336 PQPAVSPNPAVTSSAKRSSPLGAAGSTILSTSVSSTCSNSLVNTSGGSISNTSSIGSPQQQQLQL 400

Human   215 ---------------------SGLGA---ECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLA 255
                                 |.:.|   ..|..||...:|.   |||.|||:|   ...|...|
  Fly   401 QQQQAQQQQQRVQQQQRENLASAMAAGMRHHPLLPPPEAMHA---NPFQLLRMP---LPPALAQA 459

Human   256 EGRFPPTPPLFS-PPPRHHLDPHRIERLGAEEMALATHH-------------------------- 293
            ....|...|||. |.|..|   :|:|:|.:|:.   .||                          
  Fly   460 GNVVPTVAPLFGRPSPADH---YRMEQLVSEQF---RHHGFNLAAAAAAAQAQFNANGQVVGGVV 518

Human   294 ----------------------PSAF--------------------------------------- 297
                                  |:|.                                       
  Fly   519 SGSGEPRPPSSSSSGSQRGSVPPAALPPPSLSSQQQQQQQQAVQQQQQQGAQQQLQSAQQQQQSQ 583

Human   298 ---DRVLRLNP---------MAMEPPAMDF-SRRLRELAG----------NTSSPPLSP------ 333
               .:..::.|         :.:||..||| |:|||:|||          |:|||  ||      
  Fly   584 QQSQQQQQITPGLVGGAGGSLKLEPQQMDFYSQRLRQLAGTTSPGAGSTVNSSSP--SPRQKQSP 646

Human   334 --GRPSPMQRLLQPFQPGSKPPFLATPP------------------LPPLQSAPPPS-------- 370
              ..|||.|:..|......:|..| |||                  ..|..::.|||        
  Fly   647 HFASPSPSQQQQQQLATIPRPHSL-TPPEKLGDASSENGSLGLILASTPRSASTPPSKTGDVSLQ 710

Human   371 QPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMT 435
            :|.....||.:|.|.|:|::||::|:|:|||||||||..||..|:...||.:||:.|...:....
  Fly   711 EPIAHCYSCSYCDKKFRFENNLIIHQRTHTGEKPYKCTACDFECSHIQKLMKHMRVHRSPADDQD 775

Human   436 VK--SDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIP-----ENGDEEEEEDDEE 493
            .:  .||| |.|.|.|...:|                 ::.|||  |     |.||.:.:.|.:.
  Fly   776 NQDNQDDG-SNADSLETNEAD-----------------NDEDPN--PDESEEELGDGDNDPDGDG 820

Human   494 EEEEEEEEEEELTESERVDY-GFGLSLE-----AARHHENSSRGAVVGVGDESRALPDVMQGMVL 552
            :.:.|:|:|:||.|.|.:|| ...||:.     .::..:.:|.||...||       ::|....|
  Fly   821 DLDGEDEDEDELEECEDMDYKAEDLSVSNRIDGKSQSPKTTSSGATSLVG-------ELMDKFGL 878

Human   553 SSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTCDEDSVAGESDRIDDGTVNG------------- 604
            |::..:|||:.|.|.|..::...|.|.......|.::..|....:.| .:||             
  Fly   879 SNIAQYSEAYKQALQESGRKEAAAAAAAAAAAADNNNRGGAGAPLSD-KLNGLPVAALRLRDEFA 942

Human   605 RGCSPGESASGGLSKKLLLGSPSSL-------SPF--SKRIKLEKEFDLPPAAMPNTENVYSQWL 660
            :.|:..:....|       |:||.:       :||  |||:|::.                ..| 
  Fly   943 KNCNMFQQPQDG-------GAPSQVPLFNPFPNPFELSKRMKMDG----------------GDW- 983

Human   661 AGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHI 725
              :..|:.|......|.:.:..|.                                |.||:...|
  Fly   984 --WGMSQALHRNEALFENLKLKPL--------------------------------GLGGANSLI 1014

Human   726 SGPGPGRPSSKEGR-RSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHM 789
            .||    ...||.| |:||||:|||||||||||||||||||||:|||||||:|||||||||||||
  Fly  1015 QGP----LLKKESRQRNDTCEFCGKVFKNCSNLTVHRRSHTGEKPYKCELCSYACAQSSKLTRHM 1075

Human   790 KTHGQVGKDVYKCEICKMPFSVYSTLEKHMKK 821
            ||||:.|||||:|..|.|||||.|||||||:|
  Fly  1076 KTHGRTGKDVYRCRFCDMPFSVPSTLEKHMRK 1107

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BCL11ANP_075044.2 Required for nuclear body formation and for SUMO1 recruitment. /evidence=ECO:0000250 1..210 73/377 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..376 23/96 (24%)
zf-C2H2 378..399 CDD:395048 10/20 (50%)
C2H2 Zn finger 379..399 CDD:275368 9/19 (47%)
zf-H2C2_2 391..416 CDD:463886 16/24 (67%)
C2H2 Zn finger 407..427 CDD:275368 8/19 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 421..458 11/38 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..512 15/45 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 572..619 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 678..740 10/62 (16%)
DNA-binding. /evidence=ECO:0000269|PubMed:39423807, ECO:0007744|PDB:6U9Q, ECO:0007744|PDB:8TLO 737..835 72/86 (84%)
zf-C2H2 743..764 CDD:395048 19/20 (95%)
C2H2 Zn finger 744..764 CDD:275368 18/19 (95%)
zf-H2C2_2 756..781 CDD:463886 22/24 (92%)
Disordered. /evidence=ECO:0000269|PubMed:39423807 765..769 3/3 (100%)
C2H2 Zn finger 772..792 CDD:275368 18/19 (95%)
Disordered. /evidence=ECO:0000269|PubMed:39423807 793..799 3/5 (60%)
C2H2 Zn finger 802..820 CDD:275368 13/17 (76%)
CphNP_001356899.1 zf-C2H2 717..739 CDD:395048 10/21 (48%)
C2H2 Zn finger 719..739 CDD:275368 9/19 (47%)
zf-H2C2_2 731..756 CDD:463886 16/24 (67%)
C2H2 Zn finger 747..767 CDD:275368 8/19 (42%)
zf-C2H2 1029..1050 CDD:395048 19/20 (95%)
C2H2 Zn finger 1030..1050 CDD:275368 18/19 (95%)
zf-H2C2_2 1042..1067 CDD:463886 22/24 (92%)
C2H2 Zn finger 1058..1078 CDD:275368 18/19 (95%)
C2H2 Zn finger 1088..1106 CDD:275368 13/17 (76%)

Return to query results.
Submit another query.