Protein Alignment BCL11A and Bcl11a

DIOPT Version :10

• Sequence 1: NP_075044.2
• Gene: BCL11A / 53335
• HGNCID: 13221
• Length: 835
• Species: Homo sapiens
• Sequence 2: NP_001178612.1
• Gene: Bcl11a / 305589
• RGDID: 1309923
• Length: 835
• Species: Rattus norvegicus
• Alignment Length: 835
• Identity: 829/835 - (99%)
• Similarity: 830/835 - (99%)
• Gaps: 0/835 - (0%)

Human     1 MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIE 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIE 65

Human    66 HKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADK 130
            ||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 HKRKQCNGSLCLEKGVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADK 130

Human   131 LLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGL 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 LLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGL 195

Human   196 RIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFP 260
            ||||||||||||||||||||||||||||||.||||.|||||||||||||||||||||||||||||
  Rat   196 RIYLESEHGSPLTPRVGIPSGLGAECPSQPSLHGIPIADNNPFNLLRIPGSVSREASGLAEGRFP 260

Human   261 PTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGN 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 PTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGN 325

Human   326 TSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQS 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   326 TSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQS 390

Human   391 NLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDL 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   391 NLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDL 455

Human   456 VGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLE 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 VGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLE 520

Human   521 AARHHENSSRGAVVGVGDESRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTC 585
            |||||||||||||||||||.||||||||||||||||||||||||||||||||.||||||||||||
  Rat   521 AARHHENSSRGAVVGVGDEGRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRSHLAEAEGHRDTC 585

Human   586 DEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMP 650
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 DEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMP 650

Human   651 NTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSG 715
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
  Rat   651 NTENVYSQWLAGYAASRQLKDPFLTFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSG 715

Human   716 TGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACA 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   716 TGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACA 780

Human   781 QSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE 835
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   781 QSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCL11A	NP_075044.2	Required for nuclear body formation and for SUMO1 recruitment. /evidence=ECO:0000250	1..210		207/208 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		39/39 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..376		52/52 (100%)
		zf-C2H2	378..399	CDD:395048	20/20 (100%)
		C2H2 Zn finger	379..399	CDD:275368	19/19 (100%)
		zf-H2C2_2	391..416	CDD:463886	24/24 (100%)
		C2H2 Zn finger	407..427	CDD:275368	19/19 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..458		36/36 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..512		40/40 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	572..619		45/46 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	678..740		61/61 (100%)
		DNA-binding. /evidence=ECO:0000269|PubMed:39423807, ECO:0007744|PDB:6U9Q, ECO:0007744|PDB:8TLO	737..835		97/97 (100%)
		zf-C2H2	743..764	CDD:395048	20/20 (100%)
		C2H2 Zn finger	744..764	CDD:275368	19/19 (100%)
		zf-H2C2_2	756..781	CDD:463886	24/24 (100%)
		Disordered. /evidence=ECO:0000269|PubMed:39423807	765..769		3/3 (100%)
		C2H2 Zn finger	772..792	CDD:275368	19/19 (100%)
		Disordered. /evidence=ECO:0000269|PubMed:39423807	793..799		5/5 (100%)
		C2H2 Zn finger	802..820	CDD:275368	17/17 (100%)
Bcl11a	NP_001178612.1	zf-C2H2	378..399	CDD:395048	20/20 (100%)
		C2H2 Zn finger	379..399	CDD:275368	19/19 (100%)
		zf-H2C2_2	391..416	CDD:463886	24/24 (100%)
		C2H2 Zn finger	407..427	CDD:275368	19/19 (100%)
		zf-C2H2	743..764	CDD:395048	20/20 (100%)
		C2H2 Zn finger	744..764	CDD:275368	19/19 (100%)
		zf-H2C2_2	756..781	CDD:463886	24/24 (100%)
		C2H2 Zn finger	772..792	CDD:275368	19/19 (100%)
		C2H2 Zn finger	802..820	CDD:275368	17/17 (100%)