Protein Alignment BCL11A and bcl-11

DIOPT Version :10

• Sequence 1: NP_075044.2
• Gene: BCL11A / 53335
• HGNCID: 13221
• Length: 835
• Species: Homo sapiens
• Sequence 2: NP_001122913.1
• Gene: bcl-11 / 179019
• WormBaseID: WBGene00017430
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 808
• Identity: 184/808 - (22%)
• Similarity: 256/808 - (31%)
• Gaps: 320/808 - (39%)

Human    22 LEAILTDDEP---DHGPLGAPEGDH-DLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVD 82
            |..:...|.|   |......||.|. |::.||:|..:|.|.....|||||...|.|.|
 Worm    82 LSELKASDSPMSHDGADSPRPELDRTDIVVCGECHTSFSLSCFSNFIEHKVSNCGGKL------- 139

Human    83 KPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGAL 147
               :||.            ..:|||.:.|  .:..|...|     |..:...|..|:     .||
 Worm   140 ---TPSD------------DCEVTPRNFD--RSRRRTFNP-----AALIRCGRSTSA-----NAL 177

Human   148 IPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVG 212
            :|...|........: .....|.||..||:.|...|.||:|:.:.||||:..|:
 Worm   178 LPNYNMDVTTDTNDL-GSSSKSLTCCNCKERFGDVWTLLKHSYDIHGLRVCQEA----------- 230

Human   213 IP-SGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDP 276
            || |.:.....|.|                     .|.|:.
 Worm   231 IPESDVSVTSTSSP---------------------TSNESM------------------------ 250

Human   277 HRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLREL---AGNTSSPPLSPGRPSP 338
            |...|....:.:....|.:.......:|...        |.||:|:   ||.....||.
 Worm   251 HMSSRYNHNDTSSKIMHQTIKSESTMMNSFC--------SERLKEIVTRAGEQDQKPLM------ 301

Human   339 MQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEK 403
            ..|.|.|.:...:....|......|.|.....|.|..|.|..|                ..:|..
 Worm   302 ALRRLMPSEETEEEQVSAFTSTSLLNSRASQPQLPTVSSSAGF----------------QTSGSM 350

Human   404 PYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVA 468
            |       :...|.|.|....:.:              .|....|.|.|:    |.:.||.::
 Worm   351 P-------NVWMQPSMLAAMQEYY--------------ASIQQMPYPMTN----STAVALLNI-- 388

Human   469 KFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAV 533
                  ..||                 :::::::::|.:.::       :|.||:..
 Worm   389 ------SNNL-----------------QQQQQQQQQLQQQQQ-------NLIAAQPQ-------- 415

Human   534 VGVGDESRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTCDEDSVAGESDRID 598
            |.........|      :..|:...|                        |.||.|.......:
 Worm   416 VATPQPPAPTP------LFQSLNRLS------------------------TADESSYTPRPASV- 449

Human   599 DGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGY 663
               ...|..||.|                .|:|..|.:|:|:|
 Worm   450 ---AIRRRASPEE----------------ELTPPRKSMKIEEE---------------------- 473

Human   664 AASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGP 728
                   |..:...|                         |||                   :.|
 Worm   474 -------DQLIVVDD-------------------------GEL-------------------AEP 487

Human   729 GPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHG 793
            ...:|::.:..|   |.:|.|||.|.|||.||.||||||:||||:||.|||||||||||||:|||
 Worm   488 AARKPNNIKKER---CNFCNKVFTNRSNLIVHLRSHTGEKPYKCQLCPYACAQSSKLTRHMRTHG 549

Human   794 QVGKDVYKCEICKMPFSVYSTLEKHMKK 821
            |.||:.|.|.||:|||||:|||||||:|
 Worm   550 QQGKETYHCYICRMPFSVHSTLEKHMRK 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCL11A	NP_075044.2	Required for nuclear body formation and for SUMO1 recruitment. /evidence=ECO:0000250	1..210		51/191 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..41		5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..376		12/52 (23%)
		zf-C2H2	378..399	CDD:395048	2/20 (10%)
		C2H2 Zn finger	379..399	CDD:275368	1/19 (5%)
		zf-H2C2_2	391..416	CDD:463886	2/24 (8%)
		C2H2 Zn finger	407..427	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..458		4/36 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..512		3/40 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	572..619		8/46 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	678..740		6/61 (10%)
		DNA-binding. /evidence=ECO:0000269|PubMed:39423807, ECO:0007744|PDB:6U9Q, ECO:0007744|PDB:8TLO	737..835		60/85 (71%)
		zf-C2H2	743..764	CDD:395048	12/20 (60%)
		C2H2 Zn finger	744..764	CDD:275368	12/19 (63%)
		zf-H2C2_2	756..781	CDD:463886	19/24 (79%)
		Disordered. /evidence=ECO:0000269|PubMed:39423807	765..769		3/3 (100%)
		C2H2 Zn finger	772..792	CDD:275368	16/19 (84%)
		Disordered. /evidence=ECO:0000269|PubMed:39423807	793..799		4/5 (80%)
		C2H2 Zn finger	802..820	CDD:275368	14/17 (82%)
bcl-11	NP_001122913.1	zf-C2H2	499..520	CDD:395048	13/23 (57%)
		C2H2 Zn finger	500..520	CDD:275368	12/19 (63%)
		zf-H2C2_2	512..537	CDD:463886	19/24 (79%)
		C2H2 Zn finger	528..548	CDD:275368	16/19 (84%)
		C2H2 Zn finger	558..576	CDD:275368	14/17 (82%)