DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and deltaTry

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_523694.2	Gene:	deltaTry / 48343	FlyBaseID:	FBgn0010358	Length:	253	Species:	Drosophila melanogaster

Alignment Length:	248	Identity:	84/248 - (33%)
Similarity:	130/248 - (52%)	Gaps:	28/248 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   178 KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRS 242
            :|:||..|||.:.||..::.|     |.::.||||:.|...:::|.||.      :.....:.:.
  Fly    30 RIVGGSATTISSFPWQISLQR-----SGSHSCGGSIYSSNVIVTAAHCL------QSVSASVLQI 83

Human   243 RLNSN--TQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYN 305
            |..|:  :.|.:.|.|.:...|:.|:|:|:.  ||||::||..    ....|.||:.|.|.|  :
  Fly    84 RAGSSYWSSGGVTFSVSSFKNHEGYNANTMV--NDIAIIKING----ALTFSSTIKAIGLAS--S 140

Human   306 DPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHY-YGSEVTTKMLCAADPQWKT 369
            :|..|.:..::|:|..:......|.||:...|.::|..:|....| |||::.:.|:|||..  ..
  Fly   141 NPANGAAASVSGWGTLSYGSSSIPSQLQYVNVNIVSQSQCASSTYGYGSQIRSTMICAAAS--GK 203

Human   370 DSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSH 422
            |:||||||||||..    ..|.|:||||.|||..:.||||..|:....|:.|:
  Fly   204 DACQGDSGGPLVSG----GVLVGVVSWGYGCAYSNYPGVYADVAALRSWVISN 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177
		Tryp_SPc	179..422	CDD:238113	83/245 (34%)
deltaTry	NP_523694.2	Tryp_SPc	30..249	CDD:214473	82/243 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910