DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG31266

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_001138068.1	Gene:	CG31266 / 42071	FlyBaseID:	FBgn0051266	Length:	282	Species:	Drosophila melanogaster

Alignment Length:	270	Identity:	67/270 - (24%)
Similarity:	112/270 - (41%)	Gaps:	66/270 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   175 PRFKIIGGEFTTIENQPWFAAI---YRRHRGGSVTYVCGGSLISPCWVISATHCF---------- 226
            |:.::|||......|.||.|:|   |..|       :||..::...||::|..|.
  Fly    48 PQGRVIGGTTAAEGNWPWIASIQNAYSYH-------LCGAIILDETWVLTAASCVAGLRPLNLLV 105

Human   227 ----IDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGR 287
                :|:  .:.|..|               :.|..:.:|.::  |...:|||||||::.||
  Fly   106 VTGTVDW--WDLYAPY---------------YTVSQIHVHCNF--DKPLYHNDIALLQLSSK--- 148

Human   288 CAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENS--TDYLYPEQLKMTVVKLISHRECQQPHY 350
             .:.:...:.|.|..: ::.:.|......|:|...:  |...|.::...|.:.:.:.||..|..
  Fly   149 -IEFNDVTKNITLADI-DELEEGDKLTFAGWGSSEAMGTYGRYLQEASGTYLPVDACREKLQNQ- 210

Human   351 YGSEVTTKMLCAADPQWKTD----SCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTR 411
              .:|....:|.     :.|    :|.||:||||:...|   .|.||.:||..|. :..|.||.|
  Fly   211 --DDVDLGHVCV-----QMDAGQGACHGDTGGPLIDEQQ---RLVGIGNWGVPCG-RGYPDVYAR 264

Human   412 VSHFLPWIRS 421
            .:.:..|||:
  Fly   265 TAFYHDWIRT 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177		1/1 (100%)
		Tryp_SPc	179..422	CDD:238113	66/266 (25%)
CG31266	NP_001138068.1	Tryp_SPc	51..272	CDD:214473	63/263 (24%)
CG31266	NP_001138068.1	Tryp_SPc	52..275	CDD:238113	66/266 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910