DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PLAU and CG6865

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_001246825.1	Gene:	CG6865 / 40050	FlyBaseID:	FBgn0036817	Length:	285	Species:	Drosophila melanogaster

Alignment Length:	265	Identity:	79/265 - (29%)
Similarity:	128/265 - (48%)	Gaps:	42/265 - (15%)

- Green bases have known domain annotations that are detailed below.

Human   178 KIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID------YPKKEDYI 236
            ||:||........|:..::.|  |||   :.|||::||..|:::|.||..:      .|.:...:
  Fly    34 KIVGGSEAERNEMPYMVSLMR--RGG---HFCGGTIISERWILTAGHCICNGLQQFMKPAQIQGV 93

Human   237 VYLG--RSRLN--SNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQP---SRT 294
            |.|.  |..||  .|....::.:.:|::.|..|..:.:.|  |||||::       .||   |..
  Fly    94 VGLHSIREYLNGIGNGPDALRVDFKNIVPHPQYDCNDVKH--DIALLEL-------VQPIRFSSH 149

Human   295 IQTICLPSMYN----DPQFGTSCEITGFG--KENSTDYLYPEQLKMTVVKLISHRECQQPHY--- 350
            ||..|:.|...    :.::||   ::|:|  .||..:....:.|:...||:.::..|::.:.
  Fly   150 IQPSCVGSEEGHRSLEQEYGT---VSGWGWTHENQAENDRSDVLRKATVKIWNNEACERSYRSLG 211

Human   351 YGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHF 415
            ..:.:....|||.....:.|||..||||||   :.....|.|:||.|.|||....||:|||||.:
  Fly   212 KSNTIGETQLCAGYENGQIDSCWADSGGPL---MSKEHHLVGVVSTGIGCARPGLPGIYTRVSKY 273

Human   416 LPWIR 420
            :.|::
  Fly   274 VSWMQ 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177
		Tryp_SPc	179..422	CDD:238113	78/264 (30%)
CG6865	NP_001246825.1	Tryp_SPc	34..276	CDD:214473	78/261 (30%)
CG6865	NP_001246825.1	Tryp_SPc	35..280	CDD:238113	78/264 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910