DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PLAU and mas

DIOPT Version :9

Sequence 1:	NP_002649.2	Gene:	PLAU / 5328	HGNCID:	9052	Length:	431	Species:	Homo sapiens
Sequence 2:	NP_523919.1	Gene:	mas / 38499	FlyBaseID:	FBgn0011653	Length:	1047	Species:	Drosophila melanogaster

Alignment Length:	263	Identity:	85/263 - (32%)
Similarity:	126/263 - (47%)	Gaps:	39/263 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   174 RPRFKIIGGEFTTIENQPW---FAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDY 235
            |.|.:::|||  ..||..|   .|.|...::     |:||.:||...||::|.||..:..:..|.
  Fly   798 RRRARVVGGE--DGENGEWCWQVALINSLNQ-----YLCGAALIGTQWVLTAAHCVTNIVRSGDA 855

Human   236 I-VYLGRSRLNS--NTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRS----KEGRCAQPSR 293
            | |.:|...|..  .:.|.....|....:|.::::.||  .|||||||:..    ::|.|
  Fly   856 IYVRVGDYDLTRKYGSPGAQTLRVATTYIHHNHNSQTL--DNDIALLKLHGQAELRDGVC----- 913

Human   294 TIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTK 358
               .:|||:.......|..|.:||:|.......: |.:::...:.::|..||.:.   .:.||.|
  Fly   914 ---LVCLPARGVSHAAGKRCTVTGYGYMGEAGPI-PLRVREAEIPIVSDTECIRK---VNAVTEK 971

Human   359 M-------LCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFL 416
            :       .||...:.. |:||||.||||||...|...|.|:||||.||..:|.||||.:.|.|:
  Fly   972 IFILPASSFCAGGEEGH-DACQGDGGGPLVCQDDGFYELAGLVSWGFGCGRQDVPGVYVKTSSFI 1035

Human   417 PWI 419
            .||
  Fly  1036 GWI 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PLAU	NP_002649.2	Binds urokinase plasminogen activator surface receptor. /evidence=ECO:0000250	34..57
		KR	67..152	CDD:238056
		Connecting peptide	152..177		1/2 (50%)
		Tryp_SPc	179..422	CDD:238113	83/258 (32%)
mas	NP_523919.1	Tryp_SPc	803..1041	CDD:238113	83/258 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910